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Biomedical subjects

D I Webb

Publications and source records attributed to D I Webb.

12 recordsLinked to original sources
PubMed1975

Partial deficiency of hepatic glucose-6-phosphatase in an adult patient.

Patients with hepatic glucose-6-phosphatase deficiency usually have a striking clinical syndrome during childhood and are readily diagnosed by the pediatrician. An adult patient had childhood manifestations of glucose-6-phosphatase deficiency that were mild and unrecognized; symptoms of tophaceous gout, urate nephropathy and characteristic blood chemical studies suggested the diagnosis at age 39. Subsequent epinephrine and galactose tolerance tests were characteristic of hepatic glucose-6-phosphatase deficiency and direct assay of hepatic glucose-6-phosphatase confirmed a partial deficiency of the enzyme. The case emphasized that patients with this deficiency may escape diagnosis during childhood and that internists should consider the diagnosis in adolescents or young adults with acute gouty arthritis or tophaceous gout.

Adult↗
PubMedDate not supplied

The effect of granulocyte-macrophage colony stimulating factor on paroxysmal nocturnal hemoglobinuria: a case report.

This case report concerns a woman thought to have a low blood count myelodysplastic syndrome who responded poorly to cytosine arabinoside. She was treated with Granulocyte-Macrophage Colony Stimulating Factor (GM-CSF) and had an adverse reaction resembling a capillary leak syndrome. Later on, an episode of post-transfusion hemoglobinuria led to the correct diagnosis of paroxysmal nocturnal hemoglobinuria (PNH). This case report suggests an adverse effect of GM-CSF on PNH.

Aged↗
PubMedDate not supplied

Prevention of ovarian cancer with bilateral oophorectomy at time of hysterectomy.

A review of all patients with a diagnosis of ovarian cancer for five years (1989-1993) in the military hospital, the public health hospital and the two private hospitals in Anchorage, Alaska was conducted. Fifty-eight women were found with a diagnosis of advanced ovarian cancer. These charts were reviewed to determine the incidence of prior hysterectomy with preservation of ovaries. Of the fifty-eight, thirteen (22%) had prior hysterectomies with the ovaries left in place. Review of the literature supported this statistic in similar studies. Ovarian cancer has such a poor prognosis that prevention is in order. The data demonstrate that ovarian cancer could have been prevented in a significant number of these patients had they had bilateral oophorectomies at the time of hysterectomy. With the relative safety of hormonal replacement therapy, a significant way to prevent ovarian cancer is available--bilateral oophorectomy.

Adult↗
PubMedDate not supplied

A survey of the practice of prophylactic oophorectomy by gynecologists in the state of Alaska.

A questionnaire was sent to Alaskan gynecologists to evaluate their practice in regard to prophylactic oophorectomy at the time of hysterectomy. At issue is the possible benefit of prophylactic oophorectomy in the prevention of ovarian cancer. Sixty-seven questionnaires were sent and 42 (63%) were returned completed. The percentage who said they would remove apparently normal ovaries at the time of hysterectomy in premenopausal women is as follows: at 35-39 years, 5%; 40-44, 35%; 45-49, 81% and over 49 years, 95%. In postmenopausal women, 97% would recommend removal of the ovaries. 29% of respondents believe that more than 10% of ovarian cancers could be prevented by prophylactic oophorectomy at the time of hysterectomy.

Alaska↗