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Biomedical subjects

D Ia Guseĭnov

Publications and source records attributed to D Ia Guseĭnov.

9 recordsLinked to original sources
PubMed1987

[Effect of sidnocarb on learning and memory].

It has been established that in well-trained rats sydnocarb (mesocarb) does not exert a considerable effect on the generation of conditioned reflex of passive avoidance (CRPA). On the contrary, in poorly-trained animals sydnocarb significantly improves CRPA indexes at all three stages of its generation. Sydnocarb proved most effective, when injected before training (on day I). The absence of sydnocarb-induced pain threshold decrease in response to electrical pain stimulation suggests a direct drug effect on memory processes.

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PubMedDate not supplied

[The effect of pharmacological agents on the rate of lymph outflow and on blood and lymph toxicity in acute myocardial infarct].

In experiments on rabbits it was found that acute myocardial infarction (AMI) was associated with a disorder of the drainage function the lymphatic system and a drastic increase of the lymph toxicity. The administration of propranolol (obsidan), amiodaron (cordaron), lidocaine (xycaine), trimecaine (mesocaine), nitroglycerin, panangin and heparin exerted the pronounced stimulating action on the lymph outflow rate. Strophanthin-K, corglycon and digo in possessed the moderate lymphogenic effect. Novocainamide (procainamide), verapamil (isoptine) and panangin exerted no influence on the lymph outflow rate. The administration of the above mentioned drugs in the initial period of AMI sharply increased the toxic properties of the lymph; subsequently the lymph toxicity gradually decreased and was less than in control (in AMI treated with drugs).

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PubMedDate not supplied

[An electrophysiological analysis of the action of an antioxidant of the 3-hydroxypyridine class on the cerebral epileptic activity in rats with a cobalt-induced focus].

In experiments on albino male rats with chronically implanted electrodes and an epileptogenic focus in the cortical sensomotor region it was shown that a derivative of 3-hydroxy-pyridine (2-ethyl-6-methyl-3-hydroxypyridine) possesses the pronounced antiepileptic effect. The effect of the agent is related to the functional state of the epileptic system whose resistance to pharmacotherapy depends on the power of the determinant focus.

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PubMedDate not supplied

[Effect of lanthanum sulfate on cardiac activity and blood supply].

In concentration of 1:50 000, 1:25 000 and 1:1000 lanthanum sulphate is shown to reduce and in that of 1:100 -- to increase the amount of perfusion fluid from the vessels of an isolated and arrested rabbit heart. In doses of 20--40 mg/kg introduced intravenously it tended to increase the coronary circulation rate, this being attended by an insignificant fall of the arterial pressure. In these doses the compound did not change significantly the heart rate, but prevented the development of pituitrin-induced cardiac disorders in rabbits.

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