[Postoperative antibiotic therapy].
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Abscess↗
Biomedical subjects
D Inthorn
Publications and source records attributed to D Inthorn.
[Prevention and therapy of gastroduodenal stress hemorrhage in intensive care patients using the histamine H2-receptor antagonist cimetidine].
In our intensive care unit we were able to prevent almost all bleedings from stress ulcerations in patients with insufficiency of various organs by administering the H2-receptor blocker, cimetidine, in doses of 200 mg eight times per day. However, stres ulcer bleedings occurred in 14% of those patients also suffering from a sepsis. At lower doses of cimetidine, the rate of bleeding was comparable to that encountered in patients treated with antacids, i.e. 12.5% patients with multiple organ insufficiency and 42.7% with sepsis. Cimetidine did not show any therapeutic effect in case of bleeding which led to a significant fall in hemoglobin concentration.
Cimetidine↗
[Prophylaxis of acute gastric erosions with vitamin A in the rat (author's transl)].
The protective effect of Vitamin A against stress-induced ulcerations of the gastric mucosa was investigated by the hypoxic stress model of the rat. The incidence of acute mucosal erosions in the main stomach was significantly reduced by intramuscular application of 125 000 - 500 000 U Vitamin A/kg body weight prior to or immediately after the onset of stress. A dosage smaller than that or an application 2 hours after the onset of stress had no influence on the development of the acute mucosal erosions.
Animals↗
[Animal experiments on the prevention of acute gastric mucosa erosions using vitamin A].
A significant reduction of vitamin A serum levels was observed in rats which underwent a hypoxic stress. The number of gastric ulcerations secondary to stress can be significantly reduced by 125 000 to 250 000 I. E. of vitamin A applicated parenterally prior or with the onset of stress. Consequently a prophylaxis of stress ulcerations appears to be possible by application of vitamin A.
Acute Disease↗