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Biomedical subjects

D Ireland

Publications and source records attributed to D Ireland.

47 records · Page 3Linked to original sources
PubMed1985

Adenocarcinoma of the uterine cervix: a study of 73 cases.

Seventy-three patients with adenocarcinoma of the cervix were seen between 1969 and 1983. This represented 8.1% of all carcinoma of cervix seen during that period. Survival rates in stage Ib were significantly worse for those with poorly differentiated lesions and for those with involved pelvic lymph nodes. Age at presentation appeared to decline over the period of the study. When the patients with stage Ib lesions were compared with a group of stage Ib squamous carcinomas treated in the same unit, there was no difference in age at presentation, node metastasis rates, or survival. Four patients had cervical intraepithelial neoplasia (CIN) in addition to adenocarcinoma.

Adenocarcinoma↗
PubMed1984

The metaphase-arrest technique applied to human cervical epithelium. I. Technique and dose-response studies.

In order to study cell proliferation in intact human cervical epithelium, a technique involving metaphase arrest has been utilized. Metaphase accumulation is observed following intraepithelial administration of vincristine sulphate, at a predetermined optimum dose of 50 micrograms/ml. A significant delay before the onset of stathmokinetic activity is demonstrated; thereafter linearity of accumulation is apparent over a 4-hr period following injection. The technique appears applicable to the estimation and comparison of cell production rates in vivo of normal cervical epithelium, cervical intraepithelial neoplasia, wart-affected cervical epithelium and early invasive carcinoma. However, individual values are likely to be imprecise in isolation, indicating the need to study relatively large numbers of subjects in each group. Some practical difficulties are discussed.

Carcinoma, Squamous Cell↗
PubMed1984

Common hand injuries in sport.

Trauma to the hand in sport can injure soft tissues or bone and joints (or both). Soft tissue injuries generally are more serious because their diagnosis may be delayed and the results of late treatment are less rewarding. Common examples of each type of injury are discussed in this article.

Athletic Injuries↗
PubMed1982

Effect of single-dose prophylactic co-trimoxazole on the incidence of gynaecological postoperative urinary tract infection.

One hundred patients having abdominal hysterectomy for benign conditions were randomized into two groups; 50 received co-trimoxazole by intramuscular injection immediately before operation and a control group of 50 were given no antibacterial cover. Single-dose chemoprophylaxis with co-trimoxazole was effective in reducing the incidence of postoperative urinary tract infection from 35% in the control group to 4% in the treated group.

Adult↗
PubMedDate not supplied

Aggressive angiomyxoma of the perineum.

We report the case of perineal aggressive angiomyxoma in a 46-year-old woman presenting as left perineal swelling associated with superficial dyspareunia. Initial clinical examination revealed a 4- to 5-cm cystic mass in the posterior aspect of the left labia majora, not thought to be typical of a Bartholin cyst. A magnetic resonance imaging (MRI) scan revealed a well-defined 2- x 1.5- x 2-cm area posterolateral to the lower vagina on the left but anterolateral to the anal canal extending into the left ischiorectal fossa, with no obvious involvement of the anal sphincter complex. Excision biopsy was performed via an incision in the left labia majus under general anesthesia. Histologic findings were consistent with aggressive angiomyxoma of the vulva. This was confirmed by immunohistochemistry showing spindle cells positive for vimentin with strong nuclear staining for estrogen and progestogen receptors. Postoperative management following discussion at the multidisciplinary gynecological oncology meeting was to perform a repeat MRI scan 6 weeks postoperatively, and treatment with raloxifene was commenced for its antiestrogenic property.

Estrogen Antagonists↗
PubMedDate not supplied

Mesovarian hemangioma presenting as massive ascites, pelvic mass, and elevated CA125.

We present the case of a 48-year-old woman with pelvic mass, ascites, and an elevated CA125 mimicking advanced-stage ovarian cancer. She underwent laparotomy, drainage of ascites, total abdominal hysterectomy, bilateral salpingo-oophorectomy, and infracolic omentectomy. Histology confirmed this to be mesovarian hemangioma, a benign condition.

Ascites↗
PubMedDate not supplied

Endometrial adenocarcinoma following insertion of the levonorgestrel-releasing intrauterine system (mirena) in a 36-year-old woman.

The levonorgestrel-releasing intrauterine system (LNG-IUS), commonly referred to as mirena, is an effective form of contraception, which is widely used as an intrauterine device. It has a 32-mm long-shaped plastic frame that holds a reservoir (on the vertical stem) of 52 mg of levonorgestrel mixed with polydimethylsiloxane to allow a steady release of 20 mug of levonorgestrel per day within the endometrial cavity through a rate-limiting surface membrane. Apart from contraceptive purpose, it is also now commonly used in the management of heavy menstrual blood loss. This study included a 36-year old woman who developed endometrial cancer following the insertion of the LNG-IUS. Her main presentation was irregular vaginal bleeding, which is a common finding in women using this form of contraception. Although we would advice caution in investigating such women, the LNG-IUS remains a relatively safe method of contraception.

Adult↗
PubMedDate not supplied

Modification of vertical OKN and vertical OKAN asymmetry in humans during parabolic flight.

Characteristics of human vertical optokinetic nystagmus (OKN) and afternystagmus (OKAN) were examined by ISCAN imaging system on the ground and on board NASA's KC-135 aircraft in a parabolic flight study. The aircraft produced alternating periods of micro-(ca. 10(-2) G) and hyper-(ca. 1.8 G) gravitoinertial forces. Each phase lasted approximately 20 to 25 s. As compared to the baseline data on the ground, there was a significant increase of downward OKN/OKAN, whereas the upward OKN/OKAN did not change significantly in either micro- or hyper-G. As a consequence, the asymmetry of vertical OKN/OKAN, normally seen on the ground, was lost. It is postulated that the increase of downward OKN/OKAN in non-1-G conditions was governed by two different mechanisms. In micro-G, the normal inhibition effect in 1 G on the downward eye movement mediated by otolith organ activity to vertical velocity storage was removed. In hyper-G, downward OKN/OKAN was facilitated by augmented otolith-ocular reflex because of increased gravitoinertial force, so as to produce enhanced compensatory downward eye movement.

Adult↗