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Biomedical subjects

D Isenberg

Publications and source records attributed to D Isenberg.

119 records · Page 7Linked to original sources
PubMed1986

Heterozygous C2 deficiency associated with angioedema, myasthenia gravis, and systemic lupus erythematosus.

We describe a patient with myasthenia gravis, systemic lupus erythematosus, and angioedema associated with heterozygous complement factor 2 (C2) deficiency. The significance of this association is controversial, though the association of C2 deficiency with certain histocompatibility antigens suggests possible linkage to immune response genes. To our knowledge this is the first report of heterozygous C2 deficiency in association with this combination of 'autoimmune' disorders, and we discuss the aetiological implications.

Adult↗
PubMed1986

Autoantibodies, idiotypes, anti-idiotypes and autoimmunity.

The establishment of mouse and human monoclonal anti-DNA antibodies is described. Common idiotypes were identified on these antibodies employing monoclonal (mouse) and polyclonal anti-idiotypic antibodies. The significance of the presence and titer of the common idiotypes as clinical activity marker was examined in patients with systemic lupus erythematosus. Based on Jerne's network theory [Ann. Immunol. 125c: 373-389, 1974], naturally occurring anti-idiotypic antibodies to anti-DNA antibodies were reported. The utilization of this information to understand autoimmunity is discussed.

Amino Acid Sequence↗
PubMed1985

Detection of cross reactive anti-DNA antibody idiotypes on tissue-bound immunoglobulins from skin biopsies of lupus patients.

Cross-reactive anti-DNA antibody idiotypes have been identified on tissue-bound immunoglobulins from skin biopsies of patients with systemic lupus erythematosus (SLE) and discoid lupus erythematosus (DLE). Four polyclonal and two monoclonal anti-idiotypic reagents were used to screen biopsies from 24 patients with SLE, 23 patients with DLE, and 15 other patients with IgM-positive skin biopsies. Up to 46% of the SLE patients and 30% of the DLE patients were found to share idiotypes present on immunoglobulins deposited at the dermal-epidermal junction. Inhibition studies in four patients indicated that the idiotypes were on anti-DNA antibodies. In contrast, none of the anti-idiotypic antibodies bound to any of the control biopsies. These findings imply that some tissue-bound autoantibodies are derived from related families of high-frequency germ-line genes that are expressed in both SLE and DLE.

Antibodies, Antinuclear↗
PubMed1984

Myositis in other connective tissue disorders.

The clinical features, laboratory tests, EMG and muscle biopsy findings are notably similar in many patients with primary and overlap polymyositis. Studies of the immunological abnormalities and immunopathology in both types of inflammatory skeletal muscle conditions are closely related. Thus, there can be little doubt that both primary and overlap myositis are part of the spectrum of autoimmune rheumatic disease. With the recent introduction of monoclonal antibodies that are capable of defining more precisely the cells in a myositis infiltrate, and the development of more refined in vitro tests to study effector cell populations, the precise mechanisms that cause muscle damage are much closer to being identified.

Adult↗
PubMedDate not supplied

Longitudinal analysis of antibodies to histones, Sm-D peptides and ubiquitin in the serum of patients with systemic lupus erythematosus, rheumatoid arthritis and tuberculosis.

A longitudinal analysis of 12 lupus patients has been undertaken to assess their autoantibody reactivity by ELISA with histones, Sm-D peptides, ubiquitin and DNA. As controls patients with rheumatoid arthritis and tuberculosis were studied. Whereas the control groups showed little evidence of autoantibody reactivity 25% or more of the lupus patients had raised levels of autoantibodies against eight of the nine antigens tested. Of particular note was the fact that approximately 70% of the blood tested possessed antibodies reacting with Sm-D peptide 1-20. In contrast only one patient had anti-Sm antibodies by counter immunoelectrophoresis. In general the levels of antibodies to core histones reflected disease activity unlike the levels of anti-H1 antibodies. High levels of antibodies to ubiquitin often seemed to correlate inversely with active lupus and DNA antibody levels.

Adult↗
PubMedDate not supplied

Comparison of lupus activity indices.

The multiple manifestations of systemic lupus erythematosus recall the ancient Greek monster the Hydra. No one was sure how many heads it had or what they all looked like and severing one head led to the generation of others. Similarly, lupus presents with many different 'faces' and there has been a dearth of agreement about disease indices in SLE. This problem is discussed and the results of two international workshops examining three systems (BILAG, SLAM and SLEDAI) are presented. It is suggested that we may be close to agreeing how many heads the Hydra of lupus has and what they look like.

Congresses as Topic↗