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D Iványi

Publications and source records attributed to D Iványi.

14 recordsLinked to original sources
PubMed1979

H-2L: demonstration of four new allelic products and independence of H-2D and H-2L molecules.

The H-2L molecules were detected for the first time in the Dd region products using antisera against the public specificity H-2.28. This specificity was analyzed because its presence in K as well as in D region products and its apparent allelism with another public specificity, H-2.1, indicated that these two specificities may have a special position may have a special position in the H-2 system. This was corroborated by subsequent identification of H-2L molecules in Dq and Dk products using anti-H-2.28 AND ANTI-H-2.1 sera, respectively, while none of the other previously known public or private specificities was detected on H-2L molecules. We tested the products of four D region alleles which had not been analyzed previously. In each of them we identified two distinct types of molecules: H-2D, which reacts with sera agains the D region private specificity, and H-2L, which does not react with these sera, but which is detectable either by anti-H-2.28 sera (H-2Lb, H-2Lf, H-2LS) or by anti-H-2.1 sera (H-2Ldx). This increases the number of identified H-2L alleles to seven (five H-2.8+, two H-2.1+). No association between H-2D and H-2D and H-2L molecules on the cell surface was detected in capping experiments.

Alleles↗
PubMed1978

H-2.28, an alloantigenic marker allelic to H-2.1, is expressed on all three known types of H-2 molecules.

Each allele at the K or D region of the H-2 complex produces two kinds of "allelic" or mutually exclusive antigenic characteristics: its unique private specificity and a public specificity(ies) of either the H-2.28 or H-2.1 family. The private specificities of the K and D regions are expressed on H-2K and H-2D molecules, respectively. The D region produces another molecule, H-2L, which lacks the H-2K and H-2D private specificity but exhibits the H-2.28 or H-2.1 specificity. We analyzed the expression of the H-2.28 determinants on H-2K, H-2D, and H-2L molecules. When an antiserum against H-2.28 is used to sensitize cells where it can react with only H-2K molecules or H-2D molecules, by subsequent elution antibodies against H-2.28 are recovered that can also react with H-2L molecules. Hence, determinants reactive with antibodies against H-2.28 are present on H-2L as well as on H-2K and H-2D molecules. The expression of the H-2.28/H-2.1 polymorphism on all three known types of H-2 molecules, without some obvious relation to the private specificities, suggests that the antigenic determinants of these two kinds of allelic systems (private in contrast to H-2.28/H-2.1) may be controlled by separate genes, even when they are expressed on the same molecule.

Animals↗
PubMed1978

HLA antigens as possible markers of heterogeneity in schizophrenia.

The distribution of HLA-A-, B- -and -C-locus antigens was tested in 200 male patients with final diagnosis of schizophrenia. A significant increase of HLA-A28 and HLA-Cw4 antigens and haplotype A10--B18 was found. Indications were obtained for the increase of HLA-A1 in hebephrenic patients. It was presumed that the increase of CW4 represents the common denominator of the diverse findings on paranoid schizophrenia. The increase of CW4 indicates that the paranoid schizophrenia disease susceptibility locus is either the C locus itself or another closely linked locus (or loci). This would stress the importance of the HLA 'central' regions for HLA and disease associations. A hypothesis is presented which points to the possibility that HLA antigens could be genetic markers of three ethiopathogenetic subgroups of schizophrenia. The possible tests of this hypothesis are also suggested.

Adult↗
PubMed1977

HLA--Dw3 in Sjögren's syndrome.

The increased frequency of HLA-B8 in Sjögren's syndrome was recently reported independently by Gershwin et al. (1975) and Iványi et al. (1976). The association of HLA-B8 antigen with other diseases, characterized generally by impaired immunologic reactivity, has been shown (see Svejgaard et al. 1975, Dausset & Hors 1975), and in some of these diseases MLC typing has revealed the strong association also with the Dw3 determinant. The degree of association with each of the two, B8 and Dw3, varied between different diseases, in some of them having been reported to be higher for antigen B8 (Möller et al. 1976) and in the others for the determinant Dw3 (Thomsen et al. 1975, 1976). In some of the diseases, the association was found to be equally strong for both determinants (Solheim et al. 1976, Thorsby et al. 1975). In this communication, we describe the typing of HLA-Dw3 in 29 patients with Sjögren's syndrome (Ss). They represent part of the experimental group reported in a previous study (Iványi et al. 1976).

HLA Antigens↗
PubMed1977

HLA--Cw4 in paranoid schizophrenia.

On a group of 40 paranoid schizophrenic patients HLA serotypes for HLA--A, B, C antigens a significant increase of Cw4 was observed. It is argued that this finding represents the common denominator for previous data reporting increased A9 and A28 antigen in SCH because these antigens are frequently present on haplotypes bearing Cw4. The possible role of the HLA "central" parts, i.e. the chromosomal segment between HLA--A and HLA--B locus in the pathogenesis of schizophrenia was stressed.

HLA Antigens↗
PubMed1977

HLA antigens in systemic lupus erythematosus.

Forty-five patients suffering from systemic lupus erythematosus were studied in respect of their serologically defined HLA antigens. HLA-B8 antigen was found in 37-8% of patients as compared to 22% of controls. Individuals carrying the HLA-B8 antigen have a 2-15 times greater risk of developing systemic lupus erythematosus than those not carrying this antigen.

Adolescent↗
PubMed1977

Tooth allografts in children matched for HLA.

Ninety allogeneic transplants of partially developed teeth were performed in children matched for HLA antigens. Significantly better results were obtained in the group of 74 cases where 0 to 2 incompatibilities between donor and recipient were present, in comparison to 16 cases where donors differed from the recipients in 3 or 4 antigens. It is concluded that HLA match gives a clinically relevant benefit to the tooth graft recipient. The peculiarities of tooth transplantation and the difficulties with the evaluation of tooth graft survival are discussed in detail.

Adolescent↗
PubMed1976

HL-A in Sjögren's syndrome.

HL-A phenotype frequencies were studied in 36 patients with Sjögren's syndrome and compared with those of 350 healthy individuals from the same geographical area. Patients suffering from Sjögren's syndrome had a significantly higher frequency of HL-A8 (P corrected less than 0.01). The relative risk of developing Sjögren's syndrome is 3.96 for HL-A8 positive individuals.

Aged↗
PubMed1976

HLA antigens in three Siberian populations.

The distribution of HLA phenotypes, gene and haplotype frequencies was studied in three Mongoloid populations in Central Asia (Tofs, Tuvinians and Buryats). In comparison with Caucasian populations increased frequency of HLA-A9, BW40 and BW15 and haplotype A9, BW15 as well as low frequency of HLA-A1, B8 and B12 are characteristic of all three populations. Buryats seem to have the relatively highest admixture of Caucasoid genes.

Asian People↗