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Biomedical subjects

D J Bakker

Publications and source records attributed to D J Bakker.

At least 19 recordsLinked to original sources
PubMed1995

Hyperbaric oxygen treatment for haemorrhagic radiation cystitis.

Radiation-induced severe haemorrhagic cystitis is difficult to treat. Conventional treatments may decrease haematuria but do not affect the radiocystitis itself. Hyperbaric oxygen treatment has been reported to do both. We report the results of a prospective study of hyperbaric oxygen (20 sessions of 100% oxygen inhalation at 3 bar for 90 min in a multiplace hyperbaric chamber) to 40 patients with biopsy-proven radiation cystitis and severe haematuria. Haematuria disappeared completely or improved in 37 patients after treatment. Mean follow-up was 23.1 months (range 1-74); and the recurrence rate was 0.12/year. There were no adverse effects. Hyperbaric oxygen treatment should be considered for patients with severe radiation-induced haematuria.

Aged↗
PubMed1995

Hyperbaric oxygen treatment of osteoradionecrosis of the mandible. Experience in 29 patients.

In recent years hyperbaric oxygen has gained an important role in the treatment of osteoradionecrosis of the mandible. In the treatment of 29 patients with osteoradionecrosis of the mandible, a combination of surgical debridement, antibiotics, and hyperbaric oxygen was used in 27 cases. In 20 of the 29 patients the osteoradionecrosis was considered to be resolved after treatment. In 31% of the patients, the continuity of the mandible was lost. It was concluded that combined treatment of surgical debridement, antibiotics, and hyperbaric oxygen gives acceptable results and may, when used in an early phase of the disease, limit the number of patients who lose continuity of the mandible.

Adult↗
PubMed1995

Economic impact of the CNS: practitioner role.

Documentation of the economic benefit of the CNS to the institution and consumer will be vital to help justify the position of the CNS within the evolving health care system. Two tools were developed and piloted to document and evaluate one of the CNS subroles that impacts nursing productivity and patient care outcomes. The practitioner subrole was evaluated by utilizing financial analysis. The rationale for selection of variables addressed within the tools are presented, and strengths and weaknesses of the tools and the implementation process are addressed. Quantification of the outcomes reflecting the cost effectiveness of the practitioner subrole is discussed.

Cost-Benefit Analysis↗
PubMed1992

Skeletal muscle PO2 in anaerobic soft tissue infections during hyperbaric oxygen therapy.

In the present study skeletal muscle PO2 measurements were performed in patients with gas gangrene and anaerobic soft tissue infections before, during and after hyperbaric oxygen therapy. Polarographic PO2 needle electrodes appeared to be suitable for application during different ambient pressures. We found that patients with gas gangrene revealed higher skeletal muscle PO2 values than patients with an anaerobic soft tissue infection. This may be explained by a higher metabolic rate within the anaerobically infected soft tissues. The higher PO2 values in gas gangrene may be caused by alpha toxins, affecting cellular and intracellular membranes thus destroying PO2 diffusion barriers.

Bacteria, Anaerobic↗
PubMed1992

Grade-related changes in event-related potentials (ERPs) in primary school children: differences between two reading tasks.

Event-related potentials (ERPs) were recorded from the left and right temporal and parietal sites during word reading in a group of children who were followed over three consecutive years, starting at Grade 1. The first task required the child to read repeatedly presented words; the second task consisted of a series of different words, with each word being presented only once. All ERP components showed changes in amplitude as a function of grade: P240, N530, the parietal N150, and SW all decreased, whereas the temporal N360 and SW both increased. In addition, SW changed from no asymmetry to larger positivity over the right site, whereas N360 changed from symmetric amplitudes to larger amplitudes over the left hemisphere with grade. Single word presentations were associated with smaller SW activity and larger N530 and N360 amplitudes than were repeated word presentations. It was also found that proficient readers showed larger SW and N360 asymmetries and shorter vocal response times than did less proficient readers. In addition, a positive relationship was found between reading performance and ERP amplitudes over the left temporal hemisphere at Grades 2 and 3, particularly in the single word reading task. The results are discussed in terms of age-related changes in right and left hemisphere functions involved in learning to read.

Attention↗
PubMed1992

Neuropsychological classification and treatment of dyslexia.

Evidence shows that initial and advanced learning to read are predominantly mediated by the right and left cerebral hemispheres, respectively. Premature reliance on left-hemispheric reading strategies may result in L-type dyslexia, characterized by hurried and inaccurate reading. P-type dyslexia, characterized by a slow and fragmented style of reading, may result from the inability to shift from the predominant generation of right-hemispheric reading strategies to the predominant generation of left-hemispheric reading strategies. Results of investigations concerning the validity of the L/P-typology are discussed, as are the reading effects of hemisphere-specific and hemisphere-alluding stimulation in children with L- and P-type dyslexia.

Child↗
PubMed1990

Diffuse sclerosing osteomyelitis of the mandible: a new concept of its etiology.

Diffuse sclerosing osteomyelitis of the mandible is a disease of unknown etiology. The clinical and radiographic findings suggest an infectious origin, but bacteriologic and histologic findings do not support this concept. Analysis of clinical symptoms, localization of the condition, and posttreatment findings in a group of 27 patients suggest a chronic tendoperiostitis due to muscular overuse as an etiologic factor in diffuse sclerosing osteomyelitis of the mandible. This hypothesis was supported by the initial results of muscle relaxation treatment in 13 of these patients.

Adolescent↗
PubMed1990

Familial resemblance for cognitive abilities in families with P-type dyslexic, L-type dyslexic, or normal reading boys.

P-type dyslexic, L-type dyslexic, and normal reading boys, and their parents were administered a number of cognitive tasks. The P- and L-type dyslexic boys showed impaired performances on tasks representing a verbal/memory dimension. In addition, L-type dyslexics performed worse on a figure-rotation task, a result that supported the notion of a visuospatial deficit in this type of reading disturbance. The parents of P- and L-type dyslexics exhibited lowered performances on verbal/memory tasks, but they showed no evidence of impaired visuospatial functioning. Indices of familial resemblance revealed differential familial resemblances in the three types of families. In the families of P-type dyslexics, a high father-son effect was found for the visuospatial dimension. In the families of L-type dyslexics, moderately high single-parent/child effects were found for both fathers and mothers and for both the verbal/memory dimension and the visuospatial dimension. In the families of normal readers, only small single-parent/child effects were found.

Aptitude↗
PubMed1989

Event-related potentials during word-reading and figure-matching in left-handed and right-handed males and females.

In two experiments, event-related potentials at left and right occipital, parietal, and temporal sites were studied in 16 left-handers (8 male, 8 female) and 16 right-handers (8 male, 8 female). Subjects displayed extreme handedness, had a normal writing hand position, reported no left-handed relatives, and reported no perinatal traumata. In Experiment 1, centrally presented words had to be read, and nonverbal stimuli had to be matched. Condition-dependent asymmetries were found for P340 and SW components. Word-reading elicited a N500 component, whereas figure-matching did not. In Experiment 2, words presented to either the left or right visual field had to be read. It was found that N160 measures were larger, and P240, P400, and SW measures were smaller to words presented in the contralateral visual field compared to words in the ipsilateral field. Sex affected these pathway effects. In both experiments, hand preference did not significantly influence the ERP results.

Adult↗
PubMed1989

Successful treatment of radiation cystitis with hyperbaric oxygen.

This report describes the results of hyperbaric oxygen therapy in 10 patients with radiation-induced cystitis. Severe macroscopic hematuria was present in all patients and was resistant to current therapy. Previously 8 patients had been treated for bladder carcinoma and 2 for prostatic carcinoma with 60 Gy radiotherapy. Hyperbaric oxygen therapy consisted of 20 sessions of 100% oxygen inhalation at 3 bar pressure for 90 min. In 6 patients the macroscopic hematuria stopped completely and it decreased in the other patients. These 4 patients had recurrent or residual bladder malignancies.

Aged↗
PubMed1988

The development of lateral event-related potentials (ERPs) related to word naming: a four year longitudinal study.

Event-related potentials (ERPs) were recorded from the left and right temporal and parietal sites during a word naming task. Subjects were a group of children that were followed over four consecutive years starting at Kindergarten. ERP waveforms contained a sequence of positive and negative components (N150, P240, N360, N530 and SW). All components, except N150, showed changes in amplitude as a function of age, whereas SW, N360 and N150 also changed in hemispheric distribution. In addition, a relationship was found between reading performance and ERP amplitudes over the right parietal hemisphere in young children, and over the left temporal hemisphere in older children. Proficient readers showed larger (more negative) parietal N530 amplitudes than less proficient readers, especially when stimuli were degraded words. The results are discussed in terms of age-related changes in right and left hemisphere functions involved in early and advanced stages of reading, that might possibly be related to visual word recognition.

Aging↗
PubMed1988

Diffuse sclerosing osteomyelitis of the mandible: clinical radiographic and histologic findings in twenty-seven patients.

Diffuse sclerosing osteomyelitis of the mandible is a disease of obscure origin that may give rise to diagnostic problems. In the literature most authors suggest an infectious etiology. However, the results of treatment are generally poor. Clinical and radiographic findings in this study of 27 patients suggested an infectious origin of the disease. However, bacteriologic findings in 11 of these cases did not support this suggestion. The histologic findings showed a reactive hyperplasia of bone. The results of treatment, based on the assumption of an infectious etiology, were poor. It was concluded that the findings in this group of patients did not support an infectious etiology of the disease.

Adolescent↗