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D J Bezuidenhout

Publications and source records attributed to D J Bezuidenhout.

14 recordsLinked to original sources
PubMed1987

Gastric juice carcino-embryonic antigen estimation. A useful additional test in the diagnosis of gastric carcinoma?

There is a high incidence of gastric carcinoma in the coloured population of the Western Cape. Diagnostic tests other than barium meal examination or gastroscopy were investigated. In this study 50 patients were assessed and grouped according to the gastroscopic and histological findings. Twenty-five patients with gastric carcinoma and 25 with benign gastric ulcer and/or chronic atrophic gastritis and/or intestinal metaplasia were tabulated. The gastric juice and plasma carcino-embryonic antigen (CEA) levels were evaluated and compared in the two groups. The gastric juice CEA level was more useful than the plasma CEA level as an aid in diagnosing malignant gastric lesions. No correlation was evidence between CEA values and the extent of the gastric carcinoma and or histological typing. An elevated gastric juice CEA level was an additional aid in diagnosing gastric carcinoma. Markedly elevated values may also identify the high-risk patient who is prone to develop gastric carcinoma.

Adult↗
PubMed1985

Gastric carcinoma at Tygerberg Hospital, 1979-1983. A retrospective study.

A retrospective study was carried out on patients with histologically proven gastric carcinoma diagnosed at the Gastro-intestinal Clinic, Tygerberg Hospital, over a 5-year period--1979-1983. Fifty per cent of patients were coloured men. The overall median age was 65 years but the coloured patients were significantly younger than the white. The main symptoms were loss of appetite and weight, abdominal pain and vomiting. The median duration of symptoms in all patients was 3 months. An abdominal mass, anaemia and obvious weight loss were the most important physical signs. A normocytic, normochromic anaemia, an elevated erythrocyte sedimentation rate, raised liver enzyme levels and hypo-albuminaemia were the most important laboratory findings. In 96% of the 149 patients gastroscopy yielded a positive diagnosis of gastric carcinoma and barium meal examination showed abnormalities in 87%. In the majority of cases the carcinoma was poorly differentiated.

Adenocarcinoma, Mucinous↗
PubMed1984

[Double pylorus and pyloroduodenal fistulas: two case reports and discussion].

Congenital double pylorus is extremely rare; only 2 cases have been found in the English and French literature. Acquired double pylorus occurs more often; up to 1982, 66 cases had been reported. During 6 810 consecutive barium meal examinations over a period of 2 years, we diagnosed the condition in 5 patients. Two came to operation, at which the diagnosis was confirmed. These 2 cases are described. Acquired double pylorus is in reality a short pyloroduodenal fistula situated next to the pylorus, usually on the lesser curvature side. In the majority of cases it results from a pyloric ulcer penetrating into the duodenum. In a minority of cases the primary lesion is a duodenal ulcer penetrating into the pyloric area. Cases initially present with peptic ulcer symptoms. With the formation of the fistula, symptoms may disappear. Some authorities consider this to indicate spontaneous cure of the ulcer, thus obviating the need for further medical or surgical treatment. In the present 2 cases there was no remission of symptoms. None of the cases has been associated with malignant disease. It is thought that the condition may be recognized more often in future.

Aged↗
PubMed1984

Folate levels in patients with ulcerative colitis receiving sulphasalazine.

The question of folate deficiency in patients receiving sulphasalazine is still controversial. A random sample of patients with ulcerative colitis receiving sulphasalazine were studied to determine the clinical significance of the inhibition of folic acid absorption by the drug. No significant lowering of folate levels could be determined.

Colitis, Ulcerative↗
PubMed1984

A comparison of 4-week peptic ulcer healing rates following treatment with antacids and ranitidine.

Eighty-eight patients with endoscopically proven gastric and duodenal ulceration were treated with ranitidine ( Zantac ; Glaxo) or an antacid preparation containing aluminium hydroxide and magnesium trisilicate ( Gelusil ; Warner) over a 4-week period to assess healing. Clinical, haematological and biochemical assessment and endoscopy were performed at the beginning and at the end of this period. Of the duodenal ulcers, 74% healed on ranitidine therapy and 63% on Gelusil . This difference was not statistically significant (chi 2(1) = 0,55). Of the gastric ulcers 58% healed on ranitidine therapy and 35% on Gelusil , but this difference did not reach statistical significance (chi 2(1) = 1,79). There was no significant difference between the two therapies with regard to symptomatic relief in the duodenal ulcer group, but ranitidine produced significantly better results in the gastric ulcer group. No side-effects were noted in either group.

Antacids↗
PubMed1983

Enzymatic analysis of gastric microbiopsy specimens. An aid in the differential diagnosis between peptic ulcers and gastric carcinoma?

Microgastric biopsies were obtained from 20 patients with clinical, radiologic, and endoscopic features of gastric neoplasms. Biopsy specimens were taken from both macroscopically normal gastric mucosa (confirmed histology), and from the lesion. In 16 patients, various stages of adenocarcinoma were confirmed. Repeated biopsy examinations, ruled out malignancy in the four remaining patients, in which a final diagnosis of healing ulcers was established. Homogenates were prepared from the biopsy specimens, and subsequently assayed individually for acid- and alkaline phosphatase and acid proteases. Significant variances (P less than 0.05), were demonstrated for acid protease activities when tumor homogenate levels were compared; firstly with normal mucosa and secondly with ulcer homogenate levels. Biopsy hydrolase determinations may be valuable in providing important additional information not obtained from histologic examinations.

Acid Phosphatase↗
PubMed1980

Chronic organophosphate poisoning.

Prolonged exposure to organophosphates in low concentrations caused diarrhoea in 38 students, lecturers and other personnel at an agricultural college. The symptoms of those affected, plasma pseudocholinesterase levels, topography of the orchards and vegetable gardens, the various insecticides and quantities used, and the exposure due to prevailing winds have been studied. We conclude that safety and precautionary measures must be strictly enforced.

Agriculture↗
PubMed1978

Metastatic hepatocellular carcinoma of the heart. A case report.

A metastatic tumour growing in the heart more than 2 years after total removal of the primary hepatic growth is a rare event. Jaundice as a result of bile production by the metastasis is most unusual. The primary tumour did not recur in the regenerated liver. Features which may prove useful in making a clinical diagnosis are briefly considered. Death resulted from a thrombo-embolus from the right atrium lodging in the opening of the tricuspid valve.

Carcinoma, Hepatocellular↗