PubMed Health⌕ Search

Biomedical subjects

D J Cox

Publications and source records attributed to D J Cox.

8 recordsLinked to original sources
PubMed1978

Behavioral treatment parameters with primary dysmenorrhea.

Fourteen women with primary dysmenorrhea were administered four sessions of systematic desensitization (SD) by either a male or a female therapist. The following measures were taken during the flow periods before and after treatment and at a 6-month follow-up: menstrual symptom checklist, medication usage, invalid hours, and menstrual attitudes. At pretreatment, menstrually distressed women had significantly higher scores on all measures compared to a normative group and an explicitly nondistressed group. At posttreatment, treated women's scores on the dependent variables were significantly reduced. All indices were reduced to a "nondistressed level" at posttreatment and at 6-month follow-up. Type of dysmenorrhea (congestive vs. spasmodic), trait anxiety level, and therepist sex did not predict differential responsiveness to SD. SD did not affect frontailis EMG, peripheral blood flow, or pain threshold. A Retrospective Symptom Scale of menstrual distress was found to be highly reliable, valid, and sensitive.

Adolescent↗
PubMed1978

Isoelectric focusing of a dimerizing solute in rapid chemical equilibrium: comparison of simulation procedures.

The approach to isoelectric focusing equilibrium of a rapidly dimerizing solute was simulated by two different computing procedures: a stationary-grid model developed by Cann and Stimpson and a distorted-grid technique derived from the method of Cox. The results given by the two models were virtually identical at all times during the approach to equilibrium. Of the two procedures, the distorted-grid method has an advantage in computing time, while the stationary-grid model is applicable to a broader range of transport experiments. The effect on the focusing experiment of varying the electric field was examined by distorted-grid simulations. When the field was increased, the equilibrium distribution sharpened somewhat and the peak of the concentration profile shifted toward the isoelectric position of the dimer. The rate of approach to equilibrium was approximately proportional to the field strength.

Isoelectric Focusing↗
PubMed1977

Isolation and characterization of trypsin inhibitor from opaque-2 corn seeds.

Trypsin inhibitor was isolated from seeds of opaque-2 corn by affinity chromatography on a trypsin/Sepharose column. The two major forms of inhibitor eluted from the affinity column were separated by DEAE-cellulose chromatography in the presence of urea. One form of inhibitor is a single-chain protein that has a molecular weight of approximately 12,500; the second inhibitor has two polypeptide chains and appears to have been produced from the single-chain inhibitor by exposure to trypsin in the affinity chromatography step. The relationship of the inhibitor isolated from opaque-2 corn to an inhibitor previously isolated from an unspecified strain of maize by Hochstrasser et al. (Hochstrasser, K., Muss, M., and Werle, E. (1967) Z. Physiol. Chem. 348, 1337-1340) is discussed.

Chromatography, Affinity↗
PubMed1976

The fine structure of blood vessels in ethylnitrosourea-induced tumours of the rat nervous system: with special reference to the breakdown of the blood-brain barrier.

The fine structure of capillaries in and around ethylnitrosourea-induced tumours, gliomas and schwannomas, was examined in rats. A great variation was observed in the severity of changes: the degree of abnormality depended on the histological type and size of the tumour and on the site of the capillaries within the neoplasm. Endothelial cells, basement membranes and pericytes all demonstrated changes in their fine structure. The most striking alterations occurred in the endothelial cells: luminal cell membranes, tight junctions and pinocytotic activity were all modified. The widened extracellular spaces, particularly around capillaries, were frequently seen to contain proteinaceous material and haematogenous cells. Invasion of these spaces by neoplastic cells, however, rarely occurred. Formation of new capillaries was indicated by the mitotic activity of endothelial cells. These changes in the blood vessels of cerebral tumours have an important role in the breakdown of the blood-brain barrier.

Animals↗