Nine diterpenes have been isolated from the marine sponge Chelonaplysilla sp. collected in Pohnpei, Federated States of Micronesia. These include the known diterpenes 1-bromo-8-ketoambliol A acetate, dendrillolide A, dendrillolide D, norrisolide, 12-desacetoxyshahamin C, and aplyviolene. Three novel rearranged spongian diterpenes, chelonaplysins A, B, and C, were identified by interpretation of spectral data and chemical correlation with known compounds. Aplyviolene, chelonaplysin B, and chelonaplysin C exhibited antimicrobial activity against the bacterium Bacillus subtilis. The secondary metabolite composition of this collection of Chelonaplysilla sp. is compared to the composition previously reported for samples from Palau.

Animals↗

PubMedDate not supplied

Antimicrobial N-methylpyridinium salts related to the xestamines from the Caribbean sponge Calyx podatypa.

Two antimicrobial fractions were obtained from the sponge Calyx podatypa from the Bahamas. The less polar fraction contained the known compounds xestamines A [1] and B [2] and three new metabolites called xestamines D [3], E [4], and F [5]. The more polar fraction consisted of a mixture of xestamines G [6] and H [7].

Alkaloids↗

PubMedDate not supplied

Two new brominated tyrosine derivatives from the sponge Druinella (= Psammaplysilla) purpurea.

Explore the source record for details and available documents.

Animals↗

PubMedDate not supplied

A novel perlactone from the Caribbean sponge Plakortis angulospiculatus.

The Caribbean sponge Plakortis angulospiculatus contains a perlactone, plakinidone, that was identified by interpretation of spectral data. Plakinidone is the first natural product that incorporates a six-membered perlactone ring.

Animals↗