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Biomedical subjects

D J Finney

Publications and source records attributed to D J Finney.

7 recordsLinked to original sources
PubMed1991

Ethical aspects of statistical practice.

This paper embodies a personal view of the ethical considerations that the author believes should be continuously in the mind of any applied statistician or biometrician whose work involves extensive collaboration with other persons and organizations. It looks particularly at the contribution of the International Statistical Institute to the codification of principles, the duties of the statistician in relation to data and the interests of his employer or client, his responsibilities to his professional colleagues and towards society as a whole, and, by no means least; the responsibility of the client towards the statistician who works with him.

Biometry↗
PubMed1990

Repeated measurements: what is measured and what repeats?

This paper expresses a personal view of experiments involving repeated measurements; it attempts to classify types of experiment and approaches to statistical analysis: no novel procedures are proposed, only a systematic outlook on objectives and methods.

Data Interpretation, Statistical↗
PubMed1976

Point and interval estimation in the combination of bioassay results.

A procedure for combining evidence from different biological assays is shown to be equivalent both to generalized least-squares and to maximum-likelihood estimation. By appropriate nesting of hypotheses, the likelihood function can be used to test the agreement between the assays and to obtain probability limits for the combined estimate of potency. The properties of these limits are examined, with particular reference to the situation, unusual but not impossible in practice, in which the values of relative potency that they define consist of several disjoint segments instead of a single interval. The connection with general theory of estimating linear functional relations is pointed out.

Biological Assay↗
PubMed1976

Radioligand Assay.

In radioimmunoassay and immunoradiometric assay, potency estimation involves the relation between counts of radioactivity and dose. Many workers have found the regression function to be satisfactorily represented by a logistic curve with limits that are themselves unknown parameters. This paper discusses estimation of all the parameters under the supposition (supported by empirical evidence) that the variance of a count is proportional to UJ, where U is the mean count at a dose and J is a parameter that almost certainly lies between 1.0 and 2.0. Estimation is found to be very robust, both in respect of the value taken for J and over alternative forms of least squares and maximum likelihood procedures. Special attention is given to whether the assay uses one or more doses of each test preparation, the former having important limitations but permitting some simplification of formulae. Requirements for a comprehensive computer program, suitable for routine use by assayists lacking statistical expertise and designed to produce potency estimates for a series of test preparations in one assay, are described. Data from an assay of oestradiol are used to illustrate various points.

Analysis of Variance↗
PubMed1976

A computer program for parallel line bioassays.

PARLIN is a program for the statistical analysis of biological assays that are either completely randomized, or in randomized blocks, in which the regression on log dose is linear with a constant variance per response. An earlier program (McArthur et al., J. Pharmacol. Exp. Ther. 153: 573-580, 1966) has been completely rewritten, improved and extended in its facilities. PARLIN, written in FORTRAN IV, will handle up to 99 test preparations, up to 100 doses in all, and up to 50 responses per dose. It is designed with special attention to simplicity for routine use, versatility of facilities and output immediately available for all forms of reporting results. A wide choice of transformations of response is available. The output reproduces the data for verification and tabulates potency estimates with limits at probabilities .95, .99; optional output includes an analysis of variance, information on validity, values of residuals and a rough plot of the dose-response relation.

Analysis of Variance↗