Biomedical subjects

D J Hanson

Publications and source records attributed to D J Hanson.

At least 19 recordsLinked to original sources

PubMed2006

Effects of supplemental magnesium concentration of drinking water on pork quality.

Thirty-two barrows were used to determine the effects of supplemental Mg in drinking water on pork quality. Pigs were determined to be free of the halothane and Napole mutations and were individually penned. After a 7-d adjustment period, barrows (111 +/- 1 kg BW) were blocked by BW and allotted randomly within block to 0, 300, 600, or 900 mg of supplemental Mg from Mg sulfate/L of drinking water for 2 d before slaughter. Pigs were not allowed access to feed (0.13% Mg) for 15 h before slaughter but continued to have access to experimental water treatments. Pigs were loaded and transported 110 km (1.75 h) to a commercial abattoir and remained in lairage for 5 h before slaughter. The LM was removed 24 h postmortem. Retail storage was simulated for 8 d, and the remaining LM was vacuum-packaged for 25 or 50 d at 4 degrees C. Plasma Mg concentration increased linearly (P = 0.001) with Mg supplementation; however, Mg concentration of the LM was not affected (P = 0.99) by Mg supplementation. Surface exudate, drip loss, and retail fluid loss of the LM were not affected (P > 0.10) by Mg. Lightness (L*) and redness (a*) of the LM were not affected (P > 0.10) by Mg, with the exception of initial redness (cubic; P = 0.05). Pigs supplemented with 300 or 900 mg of Mg/L had lower yellowness (b*) values of the LM displayed for 0 to 6 d than pigs supplemented with 0 or 600 mg of Mg/L (cubic; P < 0.05). Lightness of the LM after 25 (quadratic; P = 0.03) or 50 (quadratic; P = 0.04) d of vacuum-packed storage was greater at 300 and 600 mg of Mg/L than at 0 or 900 mg/L. Yellowness tended to be greater after 50 d, but not after 25 d, of vacuum-packaged storage for 300 or 600 mg of Mg/L compared with 0 or 900 mg/L (quadratic; P = 0.08). Oxidation of the LM, determined by thiobarbituric acid reactive substances after 4 d of retail storage, increased linearly (P = 0.05) as Mg increased in the drinking water. Furthermore, oxidation of the LM after 8 d of retail storage tended to increase linearly (P < 0.10), primarily because of the high oxidation of LM from pigs supplemented with 900 mg of Mg/L compared with controls (224 vs. 171 +/- 19 microg/kg, respectively). Oxidation of the LM was greater for pigs supplemented with 300 or 900 mg/L compared with 0 or 600 mg of Mg/L (cubic; P < 0.06) after 25 d of vacuum-packed storage. Magnesium did not improve pork quality characteristics of practical significance in pigs without the halothane and Rendement Napole mutations.

Animal Nutritional Physiological Phenomena↗

PubMed2006

Correlated responses in growth, carcass, and meat quality traits to divergent selection for testosterone production in pigs.

The objective of this project was to characterize changes in growth, carcass yield, and meat quality traits in castrates and gilts in response to divergent selection for testosterone production. In generation 21, endogenous testosterone concentrations in Duroc boars of the high (HTL) and low (LTL) testosterone lines averaged 49.0 and 27.8 ng/mL (P < 0.01), respectively. Eight LTL and 10 HTL boars were used to sire 29 LTL and 33 HTL litters. To remove the effects of inbreeding, these same boars were mated to females of a Large White x Landrace composite (WC) to generate 11 WC by LTL litters (WLT) and 23 WC by HTL litters (WHT). Castrates and gilts were then allotted to LTL (n = 53), HTL (n = 61), WLT (n = 102), and WHT (n = 101) for testing. Growth and carcass traits analyzed included days to 114 kg (D114), ADG, backfat adjusted to 114 kg (ABF), LM area adjusted to 114 kg and predicted percent lean (PPL). Fat-O-Meater data collected were adjusted fat depth (AFD), adjusted loin depth, and percent lean. Meat quality traits characterized at 24 h postmortem included marbling score, percent lipid, pH, drip loss, color score, and Minolta L*, a*, and b*. Data were analyzed with a mixed model including fixed effects of line, mating type (purebred or crossbred), sex, and the random effect of sire nested within line. All possible interactions among fixed effects were tested. The HTL had fewer D114 (P < 0.05), greater ADG (P < 0.01), greater ABF (P < 0.01), and lower PPL (P < 0.01) than LTL. The WHT and WLT did not differ for D114, ADG, or ABF. The WHT had smaller LM area adjusted to 114 kg (P < 0.05) and greater drip loss (P < 0.05) than WLT. The WLT had lower adjusted loin depth (P < 0.05) than LTL and HTL. The LTL and HTL had greater subjective scores for marbling (P < 0.05) compared with WLT and WHT. The least squares mean for percent lipid for HTL and LTL was 4.00. The WHT had greater means for L*, a*, and b* (P < 0.05) than WLT. Pigs selected for increased testosterone production grew faster and produced fatter carcasses than pigs selected for decreased testosterone. Changes in growth, carcass yield, and meat quality traits were detected in castrates and gilts in response to divergent selection for testosterone production.

Animals↗

PubMed1997

The drinking behaviors of a sample of university students in Nanning, Guangxi province, People's Republic of China.

A Chinese translation of the Student Alcohol Questionnaire was administered to a sample of 190 students at two universities in Nanning, China. Males consumed alcohol significantly more frequently and in greater quantities than did females. A significantly higher proportion of males also experienced problems resulting from their drinking. Beer was the alcoholic beverage of choice for both males and females. Most students of both genders drank with friends, and most have also consumed with their parents; about half reported that their parents approved of their alcohol consumption. The results support earlier observations that moderate drinking is widely accepted in the Chinese culture and results in few problem.

Adolescent↗

PubMed1995

Observations on the developmental patterns and the consequences of pancreatic exocrine adenocarcinoma. Findings of 154 autopsies.

OBJECTIVE: To improve our future care of the patient with exocrine pancreatic cancer by seeking, within the limitations of our present approaches, additional information on the growth and spread of the cancer and its influences on the patient. DESIGN: Consecutive autopsies of all patients with exocrine pancreatic cancer were reviewed retrospectively by two surgeons and three pathologists. SETTINGS: Three teaching hospitals of the Medical College of Ohio, Toledo. MATERIALS: One hundred fifty-four consecutive autopsies of patients with exocrine pancreatic cancer during the period between 1952 and 1992. RESULTS: Intrapancreatic metastases or multicentric cancers were found in 12 patients. In 32 patients, pancreatic cancer skipped the lymph nodes, primarily draining the respective areas of the pancreas to metastasize to the secondary chain of nodes. In 13 patients, pulmonary metastases occurred without hepatic metastasis. Intrapancreatic contiguous extension was identified in 34 patients. Carcinoma of the body and/or tail of the pancreas was characterized by transperitoneal as well as hematogenous dissemination to a greater extent than was carcinoma of the head of the pancreas. Seven of 11 small tumors (< 2 cm in diameter) were associated with remote metastases. Relatively severe chronic obstructive pancreatitis was found to have resulted from pancreatic carcinoma in 18 cases, whereas in seven patients, pancreatic carcinoma probably developed in preexisting chronic pancreatitis. Thromboembolic disease was found in 30 patients, more frequently in the patients with the mucin-producing tumors of the pancreatic body and tail. In 21 patients, the amount of ascites was not proportional to the severity of peritoneal dissemination, vessel invasion, or recognizable hepatic dysfunction. Thromboembolic disease, severe infection, stress ulcer, and acute hemorrhagic erosive gastroenteritis were frequent systemic complications contributing to death. Malnutrition in the form of cachexia was undoubtedly a major, even dominant, feature in many patients that could not be quantitated from this data. CONCLUSIONS: Metastasizing cells frequently bypass the initial filters in lymph nodes, liver, or lung to become established in secondary or tertiary sites. Intrapancreatic metastases or multicentric tumors also may develop more frequently than generally has been recognized. Small cancers (< 2 cm in diameter) are often associated at autopsy with remote metastases. These facts would appear to limit the usefulness of the current staging of resected cancers of the pancreas. Cancers of the body or tail are characterized by transperitoneal and hematogenous spread to a greater extent than are those of the head. Anatomical studies often do not explain the cause or the extent of ascites associated with pancreatic adenocarcinoma. As previously indicated, chronic pancreatitis appears to be further confirmed as a precursor of pancreatic cancer.

Adenocarcinoma↗

PubMed1995

Von Recklinghausen's disease associated with duodenal somatostatinoma: contrast of duodenal versus pancreatic somatostatinomas.

A case of Von Recklinghausen's disease with duodenal somatostatinoma is reported. A search of the world's literature revealed 27 patients with Von Recklinghausen's disease associated with an immunohistologically proved duodenal somatostatinoma. Twenty-nine cases of duodenal somatostatinoma not associated with Von Recklinghausen's disease and 32 cases of pancreatic somatostatinomas have been identified for comparison. While their histology may be similar in many respects, the duodenal and pancreatic somatostatinomas show significant differences, especially in hormonal and growth behaviors. In contrast to its pancreatic counterpart, the duodenal somatostatinoma is frequently associated with Von Recklinghausen's disease, is seldom associated with a recognizable "somatostatin syndrome," often contains psammoma bodies, and is less frequently associated with demonstrable metastases at the time of operation.

Adult↗

PubMed1995

Malignant islet cell tumor associated with hypercalcemia.

BACKGROUND: Three cases of islet cell tumors of the pancreas with hypercalcemia were studied, and 16 similar cases have been found in a 25-year review of the English-language literature. The purpose of the study was to review the cause of the hypercalcemia and the clinical characteristics of the tumors. METHODS: Tumor tissue retrieved from paraffin-embedded blocks was studied immunohistochemically for both parathyroid hormone (PTH) and PTH-related protein (PTHrP). PTH was measured in the serum in each patient and the serum PTHrP was measured by immunoassay in one patient. RESULTS: One of our patients had a fatal serum calcium level of 26.4 mg/dl. PTHrP stains were positive in two of our tumors, and one patient had an elevated PTHrP serum level. Serum PTH levels were normal or low in each patient. All three tumors were malignant and extremely vascular. The total group of 19 patients have in common hypercalcemia associated with a normal or low serum PTH level. Although the cause of hypercalcemia has not been proved, the tumors apparently produce PTHrP, because seven of eight tumors stained positive for PTHrP and each of the four patients tested had an elevated PTHrP serum titer. The tumors are extremely vascular, are usually malignant (17 of 18), and become large, but they are compatible with a relatively long patient survival time. CONCLUSIONS: These neuroendocrine tumors associated with hypercalcemia share several characteristics, but a claim that they represent another type of "functioning islet cell tumor" should await a clearer delineation of the cause of the hypercalcemia.

Adenoma, Islet Cell↗

PubMed1994

The Student Alcohol Questionnaire: an updated reliability of the drinking patterns, problems, knowledge, and attitude subscales.

The reliabilities of the Quantity/Frequency Patterns, Problems Resulting from Drinking, Knowledge of Alcohol, and Attitudes Toward Drinking subscales of the Student Alcohol Questionnaire were calculated. The Spearman-Brown reliability coefficients of the subscales were .84, .89, .85, and .27, respectively. Values of Cronbach alpha for the four subscales were .86, .92, .86, and .55, respectively.

Adult↗

PubMed1993

Drinking games and problems related to drinking among moderate and heavy drinkers.

The playing of drinking games, the quantity-frequency of alcohol consumption, and various problems related to drinking were assessed among a national sample of 3,830 alcohol consuming students from 58 American colleges and universities during the 1990-1991 academic year. Among Light-Moderate drinkers, a significantly higher proportion of students who had played a drinking game experienced 15 of 17 drinking-related problems. On the other hand, among Heavy drinkers there was little difference between game and nongame players. A higher percentage of game players had experienced five of the problems. Generally, for many problems, more than twice as many Heavy drinkers among both game and nongame players had exhibited the problem compared to more moderate drinkers. It was concluded that game playing appeared to increase problems related to alcohol primarily among more moderate drinkers whereas those who were heavy drinkers were exhibiting more problems regardless of their game-playing status. Education about the effect of game playing among students who are moderate drinkers should be addressed.

Adult↗

PubMed1992

College students' drinking problems: a national study, 1982-1991.

The drinking problems of college students from every state in the continental United States were examined in 1982 (n = 4,405), 1985 (n = 3,453), 1988 (n = 4,343), and 1991 (n = 3,907). Observed were increases in 10 of the 17 problems studied and decreases in four; three of the decreases were in driving-related problems.

Adult↗

PubMed1991

The drinking patterns of American and Polish university students: a cross-national study.

A study of 3375 American and 1408 Polish university students was accomplished to test the hypotheses that cultural differences influence drinking patterns and beverage preferences between countries. Using the same questionnaire in both samples, the results revealed that significantly (P less than 0.001) more drinks per week were consumed by both Polish male (24.9) and female (15.2) students compared to American male (15.0) and female (7.6) students. Significantly (P less than 0.001) more wine was consumed by Polish (8.7) compared to the American (0.8) students. American female students consumed more beer than Polish female students. There was no difference between beer and spirits consumption between American and Polish males and Polish students in latter school years consumed more alcohol compared to students in the first years of school. It was concluded that the samples of students in this study reflected their cultures in terms of drinking patterns and beverage preference.

Adult↗

PubMed1991

Elements of payment for hospital-based pathologist services.

This article describes the basic elements of payment for anatomic and clinical pathology services in hospitals in the United States today. Physician payments are not targeted for major cost containment efforts by Medicare and other payers, but the financial future of individual practitioners need not be bleak, as long as certain basic business principles of practice management are followed including becoming intimately familiar with the political and regulatory environment; staying current with respect to the business standards and conventions of the profession; using extreme care when developing initial or renewal compensation contracts with hospitals; and employing generally accepted pricing, insurance and diagnosis coding, and billing standards within one's practice.

Economics, Hospital↗

PubMed1990

Influence of religion and culture on drinking behaviours: a test of hypotheses between Canada and the USA.

American Roman Catholic and mainstream Protestant students consume more alcohol and have more alcohol abuse problem compared to Canadian students within the same religious groups. Among abstinent oriented Protestants there was no difference in regards to alcohol consumption or problems related to drinking between the countries. For Jews there were mixed results with Americans exhibiting similar consumption rates but reporting more problems related to drinking compared to the Canadians. Among this sample it was concluded that religious norms have a greater influence in cohesive religious groups while cultural norms are more influential among less cohesive groups. The results also support the Canadian 'Mosaic' and American 'Melting Pot' assumption.

Adult↗

PubMed1990