Postnatal changes in the rate of high frequency bursts of inspiratory activity in cats and dogs.
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Biomedical subjects
Publications and source records attributed to D J Henderson-Smart.
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Major advances in the prevention and treatment of the respiratory distress syndrome (RDS) have occurred. Since 1970 there has been a fall in the mortality rate but not in the incidence. Persistence of the disorder could be partly accounted for by the increasing practice of elective delivery in normal pregnancies. In 1974 and 1975, 28 (25%) of babies with RDS were delivered this way and six died. The major problem appeared to be mistaken gestational age.
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The occurrence of massive air embolism in a neonate during treatment with intermittent positive-pressure respiration and positive end expiratory pressure is reported as a note of caution. It is possible that this complication may indeed be more common. Careful post-mortem examinations (including radiological examinations) are advocated in order that the true incidence of this devastating event shall be known.
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This study evaluates the perinatal outcome of infants born to ninety-five mothers with hypertension in pregnancy whose blood pressure was treated in a double blind trial comparing clonidine hydrochloride (C) and alpha-methyldopa (A). There were no fetal deaths and two neonatal deaths, giving a perinatal mortality of 2%. There was no significant difference between Groups C and A with regard to the gestation or weight at birth, incidence of intrauterine growth retardation, or condition at birth as judged by Apgar scores and acid-base status. No infant in either group developed significant hypotension or rebound hypertension. The blood pressure was not significantly different between Groups C and A, and controls. In each of these three groups there was a similar significant rise in systolic blood pressure with age.
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