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Biomedical subjects

D J Jackson

Publications and source records attributed to D J Jackson.

At least 19 recordsLinked to original sources
PubMed1992

Specific anti-A responses of SCID mice populated with human lymphoid cells from peripheral blood, umbilical cord, bone marrow and spleen after immunization with group A erythrocytes [corrected].

Mice with severe combined immunodeficiency (SCID) were injected i.p. with 10 x 10(6) or 50 x 10(6) human leukocytes obtained from adult peripheral blood, umbilical cord blood, bone marrow and spleen from six group O individuals, together with allogeneic group A erythrocytes. Mice were bled every two weeks and levels of human IgG, IgM and anti-A were determined in the murine plasma. Spleen cells elicited the highest Ig levels (up to 5.2 mg/ml IgG) and umbilical cord the least (0-0.16 mg/ml IgG); maximum IgG levels were obtained at about 6-8 weeks after injection. Anti-A was detected in mice receiving adult peripheral blood or spleen leukocytes and immunizing erythrocytes 4-6 weeks after injection. Mice injected with the higher dose of leukocytes gave the best anti-A responses, but were more likely to develop tumours after 8 weeks.

ABO Blood-Group System↗
PubMed1992

Lymphadenopathy and hepatosplenomegaly in the 1st year in children infected by HIV-1 in Zaire.

The children of 50 women positive for antibody to human immunodeficiency virus type 1 (HIV-1) and 42 children of antibody-negative mothers were examined for lymphadenopathy and hepatosplenomegaly at 3-month intervals during the 1st year of life. Lymphadenopathy was found to be significantly more frequent at 6 months (p less than 0.01), 9 months (p less than 0.001) and 12 months (p less than 0.01) in children who were subsequently shown to be infected with HIV-1. Hepatomegaly was seen more frequently (p less than 0.05) in the 1st year in HIV-1-infected children than in uninfected children. Splenomegaly was not more frequent in HIV-1-infected children in this area which is holoendemic for falciparum malaria.

AIDS Serodiagnosis↗
PubMed1992

Health and geographic mobility among the recently widowed.

The death of a spouse has been described as the most disruptive and difficult role transition that an individual confronts throughout the life course. Using data from the 1984 and 1986 waves of the Longitudinal Study of Aging conducted by the National Center for Health Statistics, we examined the probability of moving associated with changes in functional disability levels over a two-year period while controlling for recent widowhood. We found that the greater the increase in instrumental disability between 1984 and 1986, the greater the probability of a move. We also found that the event of becoming a widow greatly increases the probability of a move when health declines.

Activities of Daily Living↗
PubMed1991

The second move: health and geographic mobility.

Litwak and Longino (1987) proposed a life course typology of elderly migration in which the second type of move is associated with the development of chronic disabilities that make it difficult to perform everyday household tasks. We examined this intermediate type of move, classified between "amenity moves" in early retirement and "institutional" moves in late old age, a type of migration that had not been verified in existing research. Using data from the 1984 and 1986 waves of the Longitudinal Study of Aging by the National Center for Health Statistics, we tested the proposition that the proportion of moves increases with higher levels of instrumental functional disability over time. The probabilities generated by our model have an impressive range as predicted by Litwak and Longino in the second move portion of their model of retirement migration.

Aged↗
PubMed1991

Contributions to the history of psychology: LXXIV. Edith Banfield Jackson: a pioneer in psychoanalysis.

Edith Jackson, recipient of one of Sigmund Freud's coveted rings, served him well as an ambassador for psychoanalysis. As a child psychiatrist for 25 years at the Yale School of Medicine, she developed the rooming-in plan which allowed parents and newborns to be together from birth. With Anna Freud and Dorothy Burlingham, she opened the Jackson Nursery, a precursor of American daycare centers. Among the most important people in developing the field of child psychology, Edith was one of the early psychologists who recognized the importance of satisfying the emotional as well as the physical needs of the newborn.

Child Psychiatry↗
PubMed1990

Racial congruity as a contextual correlate of mental disorder.

The effects of exposure to racially dissonant residential environments on depressive psychopathology are explored. Epidemiological survey data are shown to support the hypothesis that an inverse relationship exists between racial congruity and depression. Limitations of the analysis are discussed, as are the social implications of the findings.

Adjustment Disorders↗
PubMed1979

Vitamin absorption in the in vivo intestine of normal and infected (Hymenolepis diminuta: Cestoda) rats.

Uptake and serosal transfer of the vitamins thiamine, riboflavin and folic acid have been studied in vivo in normal and parasitized rats infected with Hymenolepis diminuta (Cestoda). Regional differences in intestinal uptake of all three vitamins in both uninfected and parasitized animals were not satistically significant. In the parasitized intestine mucosal uptake and serosal transfer of thiamine were significantly inhibited, with increased mucosal accumulation of the vitamin as luminal thiamine concentration increased. Apparent increased riboflavin mucosal uptake in parasitized animals, was not matched by the reduced serosal transfer, suggesting adsorption of the vitamin in the unstirred aqueous layers. Mucosal uptake of folic acid increased in the parasitized gut; serosal transfer and mucosal accumulation were not affected. These results, indicating vitamin malabsorption associated with infection by H. diminuta, are consistent with the parasite inhibiting mucosal passive transport mechanisms. This conclusion is supported by the changes in net water fluxes associated with vitamin uptake in the parasitized intestine.

Animals↗