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Biomedical subjects

D J Lugg

Publications and source records attributed to D J Lugg.

27 records · Page 2Linked to original sources
PubMed1986

Cell-mediated immunity in healthy adults in Antarctica and the sub-Antarctic.

Cell-mediated immune responses were studied in 2 Antarctic and sub-Antarctic groups at quarterly intervals over a wintering year, using the cutaneous CMI Multitest. The sub-Antarctic population at Macquarie Island (M.I.) had levels of responsiveness and hypoergy comparable to other healthy populations in temperate regions. The Antarctic group at Mawson showed decreased scores and total number of positive responses to antigens, and a significantly elevated incidence of anergy and hypoergy. Quarterly skin testing showed considerable variability in subject responsiveness to specific antigens at different times over the year. However, only 2 antigens at M.I., trichophyton and proteus, showed a significant seasonal variation in score. There was no statistically significant seasonal variation in antigen scores at Mawson. It is concluded that environment and stress factors in Antarctic expeditions are responsible for the decreased immunological responsiveness.

Acclimatization↗
PubMed1975

Antarctic medicine, 1775-1975. I.

An historical review is made of Antarctic medical practice, which is unique because of the absence of an indigenous population. This review begins with the primitive shipboard practice of doctors accompanying Captain James Cook around 1775 and concludes with the modern era of permanent stations and vast scientific endeavour. The heroic era of Scott, Shackleton, Amundsen and Mawson and the highly mechanized transition period are contrasted with the present day. Medical practice on modern expeditions has reached a high standard, but there is still much to be learned concerning human adaptation. Comment is made on the possible utilization of Antarctica's natural resources bringing increases in polar populations and facilitating the expansion of medical research in the future era of polar medicine.

Anesthesia, Inhalation↗