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Biomedical subjects

D J Nolan

Publications and source records attributed to D J Nolan.

At least 73 records · Page 4Linked to original sources

Direct mechanical ventricular assistance during ventricular fibrillation.

A technique of direct mechanical ventricular assistance (DMVA) has been available since 1966. Ventricular assistance is provided by a glass cup lined with a Silastic diaphragm. It is held on the cardiac ventricles by suction. Alternating positive and negative pressure in the space between the cup and the diaphragm provides a pumping mechanism for blood flow. DMVA was compared to closed chest massage (CCM) and open chest massage (OCM) during ventricular fibrillation in six dogs. Each technique was applied for 10 minutes. Three dogs had CCM followed by OCM and then DMVA. Three dogs had only OCM and DMVA. Blood pressure and cardiac output were measured. All variables were calculated as a percentage of pre-ventricular-fibrillation values. Mean blood pressure was 19.7% with CCM, 39.8% with OCM, and 55.1% with DMVA. Systolic blood pressure was 25.8% with CCM, 51.9% with OCM, and 64.0% with DMVA. Diastolic blood pressure was 17.3% with CCM, 37.3% with OCM, and 48.9% with DMVA. Cardiac output was 13.8% with CCM, 37.1% with OCM, and 58.0% with DMVA. For each variable, OCM produced statistically higher values than did CCM. DMVA produced statistically higher values than did OCM for all variables. These preliminary results suggest that DMVA may be superior to currently available methods of cardiac massage during ventricular fibrillation.

Animals↗

The barium infusion in small intestinal obstruction.

During a two-year period 26 patients with suspected small bowel obstruction were examined by infusing barium into the small intestine. Mechanical obstruction was confirmed in 25 patients and the level of obstruction was shown in all except one who had carcinoma of the caecum. Surgery was avoided in nine patients-six of whom had Crohn's disease, two had adhesions and the investigation showed no abnormality in one patient. There were no complications associated with the examination or with the subsequent operation.

Barium↗

Crohn's disease of the small intestine: a comparative study of the radiological and pathological appearances.

A prospective study was carried out to compare the radiological and pathological appearances of Crohn's disease of the small intestine. The X-ray examinations were carried out by infusing barium directly into the small intestine. Thirty-six patients who were operated on for Crohn's disease of the small intestine are included. There was excellent correlation between the radiological appearances and the findings at morbid anatomy.

Adolescent↗

Crohn's disease of the small intestine: a review of the radiological appearances in 100 consecutive patients examined by a barium infusion technique.

The radiological features of Crohn's disease of the small intestine are described in a report on 100 patients examined by a barium infusion method. The examination is performed by introducing a large volume of barium suspension through a tube directly into the small intestine. A multiplicity of radiological signs were seen in the majority of the examinations. Discrete and fissure ulcers were present in many cases; longitudinal ulcers, sinuses and fistulae were seen less frequently. Other signs commonly seen were strictures, in many cases with proximal dilatation, thickening and distortion of the mucosal folds, cobblestoning, asymmetrical involvement, thickening of the wall of diseased intestine and good demarcation of normal from abnormal small intestine. Adhesions, skip lesions, gross distortion, a featureless outline of the diseased intestine and pseudo polyps were less commonly seen. The disease was more extensive in patients who previously had resections for small intestinal Crohn's disease.

Adolescent↗

Symptomless diverticular disease and intake of dietary fibre.

A study is reported in which the prevalence of symptomless diverticular disease of the colon is related to the consumption of dietary fibre in vegetarians and non-vegetarians. Vegetarians had a significantly higher mean fibre intake (41.5 g/day) than non-vegetarians (21.4 g/day). Diverticular disease was commoner in non-vegetarians (33%) than in vegetarians (12%). Comparison of subjects with and without diverticular disease in the vegetarian and non-vegetarian groups provided some further evidence that a low intake of cereal fibre is associated with the presence of diverticular disease.

Aged↗

Small bowel strictures after blunt abdominal trauma.

Two patients with strictures of the small intestine after blunt abdominal trauma are reported. In the first there were multiple severe injuries and the ileal stricture due to a mesenteric tear was not diagnosed until 6 weeks later. In the second an apparently minor injury was responsible for direct damage to the wall of the jejunum and a subsequent stricture.

Adult↗

Rapid duodenal and jejunal intubation.

A size 12 French radiopaque catheter, 135 cm long, suitable for rapid duodenal and jejunal intubation, is described. Its size and flexibility enable it to be passed with ease through the nose, stomach and duodenum. A guide wire is used to act as a stiffener as the catheter is passed through the stomach. The catheter is suitable for infusing barium directly into the small intestine and for performing hypotonic duodenography. The technique for duodenal and jejunal intubation is discussed.

Barium Sulfate↗

Combined fine needle percutaneous transhepatic cholangiography and hypotonic duodenography in obstructive jaundice.

The information obtained at percutaneous transhepatic cholangiography in patients with obstructive jaundice is not always conclusive about the nature of the obstructing lesion. Hypotonic duodenography performed immediately after transhepatic cholangiography may assist in such cases by demonstrating the presence or absence of duodenal involvement. This ensures that the appropriate surgical procedure can be planned before operation. Our experience using the combined techniques in nine patients is reported.

Aged↗

Small bowel melaena: 2 cases diagnosed by angiography.

Two cases of small bowel tumour presenting with melaena are reported. Selective visceral arteriography was found to be invaluable in the management of these cases. The first case presented with intermittent bleeding causing anaemia. Conventional barium studies of the small and large bowel revealed no abnormality. Superior mesenteric angiography revealed a mass lesion in the jejunum, with features characteristic of a leiomyoma. The second case presented with massive gastrointestinal bleeding. Selective visceral angiography was performed initially and revealed a large, mainly avascular, mass lesion in the ileum. Pathological examination showed a leiomyoma which had undergone cystic degeneration. The value of selective angiography in patients with suspected small bowel bleeding is discussed..

Adult↗

Chondroblastoma of bone.

Chondroblastoma is a rare benign neoplasm of cartilaginous origin. It appears as a round or oval translucent area with a thin sclerotic rim situated most often in the epiphysis of a long bone, and occurs mainly in the 12-20 age group. It has an excellent prognosis and the radiological features should suggest the correct diagnosis. Ten cases have been reviewed in this paper. The clinical, pathological as well as the radiological features and the differential diagnosis of this entity are discussed. It is hoped that this will help in its earlier diagnosis.

Adolescent↗