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Biomedical subjects

D J Reid

Publications and source records attributed to D J Reid.

At least 37 records · Page 2Linked to original sources
PubMed1989

Surgical treatment of secondary and tertiary hyperparathyroidism.

All patients with chronic renal failure have secondary hyperparathyroidism shown by elevated serum parathormone. Medical and surgical treatment is involves the use of phosphate binders, one alpha and increased frequency of dialysis. Surgery is indicated when medical treatment fails to control the Ca2+ PO4(2-) levels that activate renal osteodystrophy. High alkaline phosphatase and Ca2+ above 2.7 mmol/l are indications for surgery. Careful preoperative preparation and postoperative control minimise complications of haemorrhage, sepsis, tetany and cardiac arrhythmias. Long-term complications are hypoparathyroidism and recurrent hyperparathyroidism. Shortened dialysis periods may lead to increased parathyroid complications.

Humans↗
PubMed1987

Hyperthyroidism and hypothyroidism complicating the treatment of thyrotoxicosis.

Three separate studies of recurrent hyperthyroidism and hypothyroidism in groups of patients treated for thyrotoxicosis by anti-thyroid drugs, surgery and radioiodine are presented. The incidence is compared in the three groups. Two hundred and fifty-three patients with primary thyrotoxicosis received a year-long course of anti-thyroid drugs: 43 per cent relapsed in the first year following the completion of treatment. Of those remaining euthyroid at the beginning of the second year after treatment a further 21 per cent relapsed during that year and in subsequent years, 21 per cent, 18 per cent and 13 per cent of those remaining euthyroid at the start of the third, fourth and fifth years relapsed. Of those followed for the full 5 years 26 per cent remained in remission and 74 per cent had relapsed over this period. After bilateral subtotal thyroidectomy for thyrotoxicosis in 146 patients, 19 per cent were hypothyroid and 1.4 per cent had relapsed 18 months after surgery. The incidence of postoperative hypothyroidism was lower in the younger patients (under 25 years). The absence of thyroid auto-antibodies preoperatively is an indication of a favourable result. The histological recognition of lymphocytic infiltration in the gland and the presence of thyroid auto-antibodies indicated an unfavourable outcome. Radioactive iodine gave an unpredictable response at therapeutic doses with 24 per cent relapsing in the first year after treatment. With ablative doses of radioactive iodine the incidence of hypothyroidism reached 94 per cent at 5 years after treatment. Surgery gives the best long-term results of the three treatment options and is the treatment of choice for the young, the severely toxic and those with toxic multinodular goitre.

Adolescent↗
PubMed1986

Thyrotoxicosis: changing trends in treatment.

A review of treatment of thyrotoxicosis over a 14 year period has led to three modifications in our approach. Firstly, we now treat fewer patients with a prolonged course of carbimazole, recommending surgery as primary treatment in more patients, particularly the young and middle aged severe thyrotoxics. Secondly, we use conventional therapeutic doses of radioiodine very much less frequently, because of the unpredictable response, and when using radioiodine attempt thyroid ablation more frequently. Thirdly, conventional 'ablative' doses are frequently too low.

Adolescent↗
PubMed1982

Use of objective measurement in the validation of self-reported smoking in children aged 10 and 11 years: saliva thiocyanate.

This study of objective measurement of smoking behaviour reports the findings from a sample of 421 children aged 10 and 11 years from Sheffield. Saliva thiocyanate determination did not provide a satisfactory objective method of validating the self-reported smoking of children in this age group. There was a trend (non-significant) for non-smoking children from homes in which a close relative smoked to have higher concentrations of saliva thiocyanate than non-smokers from "non-smoking" homes. Prior knowledge that a scientific test predicting smoking behaviour would be taken after completion of a questionnaire on smoking increased the self-reportage of experimental smoking.

Child↗
PubMed1981

Effects of rehabilitation on the jaws and teeth of protein-deficient and calorie-deficient pigs.

The growth of the jaws and teeth was examined in pigs which had been fed protein-deficient and calorie-deficient diets for the first year of life and thereafter allowed unlimited food. After 2 years of rehabilitation, jaw size had almost reached that of well-fed controls, although in the mandible the labial alveolar process remained abnormally proclined and in both jaws the crowns of third permanent molars were smaller than in control animals. Calorie-deficient pigs did not recover as well as did protein-deficient animals. Pigs fed a calorie-deficient diet for the first 2 years of life before rehabilitation also made a good recovery and were only slightly smaller in most dimensions than those undernourished for 1 year and then rehabilitated. Despite the excellent recovery in jaw dimensions, some malposition of teeth persisted after rehabilitation, especially in animals which had been undernourished for 2 years.

Animals↗
PubMed1979

Metrical analysis of growth changes in the jaws and teeth of normal, protein deficient and calorie deficient pigs.

Weanling pigs were separated into three groups: control animals were allowed unlimited food; protein deficient animals were allowed unlimited carbohydrate or fat but restricted in protein intake; calorie deficient animals were restricted in total food intake. The skulls and teeth of animals killed at one year and at two years of age were measured from radiographs, and from the results were derived the following conclusions: (1) Pigs fed on protein and on calorie deficient diets all showed considerable retardation of the growth of jaws and teeth, consistently more severe in the calorie deficient than in the protein deficient animals. (2) The shape of the mandible was altered by both types of malnutrition, the height of the ascending ramus being reduced to a greater extent than either its anteroposterior width or the length of the body of the mandible. The labial alveolar process became more proclined with increasingly severe malnutrition. (3) The upper and lower jaws were retarded to a similar extent in both groups of experimentally malnourished animals. (4) Retardation of tooth growth was less severe than that of jaw growth. (5) Contralateral asymmetry of molar crown size in the protein deficient animals was initally quite marked, but when the teeth were approaching their final size the asymmetry was no greater than in control animals.

Animals↗