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Biomedical subjects

D J Richards

Publications and source records attributed to D J Richards.

At least 19 recordsLinked to original sources

Nutritional products as drugs or food implications for development.

It is currently recognized that food, other than supplying calories, produces profound effects on bodily function. Consumers and patients receive information regarding whole foods, individual ingredients, and diets from many sources, most of which are unverified for efficacy and safety. No satisfactory mechanism exists for the production of this data, and its regulatory oversight is made more difficult, since many of the products are in everyday commerce and readily available to the consumer. The differences between the methods by which consumer-patient behavior is modified, are discussed. A framework is suggested by which research and development investment over time could be created and maintained, so as to provide well-documented data on safety and medical benefits. Patent and regulatory issues are important elements of the proprietary position essential to sustain an intensive, extended research and development effort in this area.

Aged

Results of Buck screw fusion in grade I spondylolisthesis.

The results of posterolateral screw fixation using the Buck technique performed on 24 patients with painful isthmic spondylolysis and up to grade I spondylolisthesis in the lumbar spine are reported. The average age at operation was 29 years and average follow-up was 5 years with a range of 13 months to 12 years. Operations were performed for persistent disabling low back pain. At review 21 patients were either free of pain or complained of only occasional backache and discomfort. All but two patients were satisfied with the operation and rated the result as excellent or good. It is concluded that Buck screw fixation is a safe and reliable method of treatment for painful Grade I spondylolisthesis due to isthmic spondylolysis in the young active adult with a low complication rate.

Adolescent

Contraceptive action of continuous low doses of norgestrel.

Norgestrel in a dose of 50 mug. was administered daily to 188 women during 2,250 menstrual cycles. Only two pregnancies occurred because of failure of the method, giving a failure rate of 1.1 pregnancies per 100 woman-years. The method was acceptable to most of the subjects, and side-effects, other than menstrual irregularity, were minimal; 68% of the cycles were 28 +/-5 days in length and 21% were less than 23 days. There did not appear to be any increased incidence of amenorrhoea. The antifertility action of continuous administration of low doses of progestogen may be due to an effect on corpus luteum function, in addition to the effects on cervical mucus, endometrium, and tubal transport of ova. The optimum dose of norgestrel appears to be in the range of 50-75 mug./day.

Adolescent