PubMed Health⌕ Search

Biomedical subjects

D J Seddon

Publications and source records attributed to D J Seddon.

13 recordsLinked to original sources
PubMed1997

Data quality in population-based cancer registration: an assessment of the Merseyside and Cheshire Cancer Registry.

Merseyside and Cheshire Cancer Registry (MCCR) data quality was assessed by applying literature-based measures to 27,942 cases diagnosed in 1990 and 1991. Registrations after death (n = 8535) were also audited (n = 917) to estimate death certificate only (DCO) case accuracy and the proportion of registrations notified by death certificate (DC). Ascertainment appeared to be high from the registration/mortality ratio for lung [1.01:1] and to be low from capture-recapture estimates (59.4%), varying significantly with site from oesophagus [92.2% (95% CI 88.5-95.9)] to breast [47.5 (95% CI 41.8-53.2)]. The estimated DC-dependent proportion was 20% (5601 out of 27 942) with successful traceback in 3533 out of 5601 (63.1%) cases. DCO flagging (2497 out of 27,942, 8.9%) overestimated true DCO cases (2068 out of 27,942, 7.4%). The proportion of cases of unknown primary site was low (1.5%), varying significantly with age [0-4.2%, (95% CI 2.5-5.9)] and district [0.8% (95% CI 0.3-1.3) to 2.2% (95% CI 1.8-2.6)]. The median diagnosis to registration interval appeared to be good (10 weeks), varying significantly with site (P < 0.0001), age (P < 0.0001) and district (P < 0.0001). The proportion with a verified diagnosis was 77.3%, varying significantly with site [lung 55.2% (95% CI 53.7-56.7) to cervix 96.9% (95% CI 96.3-97.5)], age [45.2% (95% CI 40.9-49.5) to 97.5% (95% CI 96.4-98.6)] and district [71.8% (95% CI 69.9-73.8) to 82.5% (95% CI 80.7-84.3)]. The DCO percentages varied similarly by site [non-melanoma skin 0.4% (95% CI 0.2-0.6) to lung 22.6% CI (95% 19.9-25.3)], age [0.7(95% CI 0.1-1.4) to 23.0 (95% CI 19.4-26.6)] and district [6.9% (95% CI 5.7-8.1) to 13.9% (95% CI 12.9-15.0)]. MCCR data quality varied with age, site and district - inviting action - and apparently compares favourably with elsewhere, although deficiencies in published data hampered definitive assessment. Putting quality assurance into practice identified shortcomings in the scope, definition and application of existing measures, and absent standards impeded interpretation. Cancer registry quality assurance should henceforward be within an explicit framework of agreed and standardized measures.

Confidence Intervals↗
PubMed1991

Measurement of lung tissue mass in interstitial lung disease.

A gamma camera and 99m Technetium were used to obtain transmission and emission scans of the thorax in order to estimate transthoracic tissue thickness, and volumes of blood and interstitial tissue in each pixel of the gamma camera image. This technique has been applied to six patients with stage 2/3 pulmonary sarcoidosis and eight with cryptogenic fibrosing alveolitis and age and sex-matched control groups without lung disease. In both conditions transthoracic tissue thickness was significantly increased: mean values (SD) were 14.6 (1.8) cm in cryptogenic fibrosing alveolitis and 12.3 (2.2) cm in stage 2/3 sarcoidosis. This was partially accounted for by an increase in the interstitial fluid compartment. Blood volume was unaffected. Measurement of transthoracic tissue thickness involves minimal radiation exposure and may be of value in monitoring these diseases; measurement of interstitial fluid volume may give information on disease activity.

Adult↗
PubMed1991

Estimation of lung oedema in humans by transmission-emission scintigraphy with 99Tcm.

UNLABELLED: We have used a combination of transmission and emission gamma camera techniques to scan the thorax in the anteroposterior plane in 21 patients with partially treated cardiogenic pulmonary oedema and have compared their results with those from 20 age-matched normal subjects who were scanned previously. For transmission scanning, an external 99Tcm flood source was used; for emission scanning we labelled sequentially the vascular compartment with 99Tcm autologous erythrocytes and the interstitium with 99Tcm diethylenetriaminepentaacetic acid (99Tcm-DTPA). From the transmission scans we derived the transthoracic tissue thickness (Tt) and from the emission scans, after correction for attenuation, the regional blood and interstitial volumes. In the lower zone of the right lung, mean (S.D.) Tt in normal subjects was 10.9 (S.D. 3.1) cm and in subjects with lung oedema was 12.5 (S.D. 3.1) cm (P = 0.07). There was a weak correlation between Tt and a radiographic numerical score of oedema severity (r = 0.47, P less than 0.05). In eight subjects with lung oedema, lung tissue thickness (T1) was estimated (by subtraction from Tt of radiographically estimated chest wall thickness). The T1 correlated closely with the radiographic score (r = 0.78, P less than 0.01). There was no significant change in blood or interstitial volumes in oedema. IN CONCLUSION: (1) transmission scanning gives an indication of oedema severity if an allowance is made for chest wall thickness; (2) 99Tcm-DTPA fails to equilibrate fully with oedema liquid during an equilibration period of 5 min.

Adult↗
PubMed1990

Thoracic tissue thickness measured by transmission scintigraphy with 99Tcm.

A flood source containing 25 mCi of technetium-99m (99Tcm) was used to measure thoracic tissue thickness (Tt) in 20 healthy subjects, 14 patients with cardiogenic pulmonary oedema, 8 patients with biopsy proven cryptogenic fibrosing alveolitis (CFA) and 10 subjects with radiographic evidence of severe, widespread emphysema. Unattenuated counts from the flood source were acquired first, and then with the subject seated between the flood source and the gamma camera, a second scan of transmitted counts was acquired. Assuming a constant linear attenuation coefficient of 0.135 cm-1, we calculated Tt per pixel of the gamma camera image, thus creating a profile of Tt throughout the length of the thorax. In normal subjects mean (S.D.) Tt at the base of the right lung was 10.8 (2.4) cm. In patients with pulmonary oedema, CFA and emphysema, mean (S.D.) values for Tt, in cm, were 12.9 (2.7) p less than 0.05, 14.4 (1.9) p less than 0.001 and 6.0 (1.1) p less than 0.0001 respectively. This simple, quick and inexpensive technique could be used to give regional measurements of Tt.

Adult↗
PubMed1990

Carcinoma of the bronchus in young adults.

Thirty patients with bronchial carcinoma, aged 45 or less, were identified as having attended this or other local chest clinics. In four cases the diagnosis was reached after four or more months of investigations. In two of these cases, pulmonary tuberculosis was incorrectly suspected to be responsible for the illness of the patient. Compared with the disease as it affects all age groups, there appeared to be no greater incidence of any particular presenting symptom. In the group of patients studied, there was an excess of small cell carcinoma compared with that expected.

Adenocarcinoma↗
PubMed1989

Measurement of lung tissue mass in Pneumocystis carinii pneumonia.

Transmission-emission scanning of the thorax with a flood source of technetium-99m (99mTc), autologous 99mTc labelled red blood cells, and diethylenetriaminepenta-acetic acid (99mTc DTPA) allows measurement of thoracic tissue thickness and blood and interstitial volume per pixel of the gamma camera image. Volume of blood or interstitium per pixel divided by pixel area gives the thoracic tissue thickness for these two compartments. A measure of lung tissue thickness may be obtained by subtracting chest wall thickness as measured on a lateral chest radiograph. As part of the evaluation of this technique 13 patients were scanned before treatment for proved or presumed pneumocystis pneumonia and their results were compared with those of 12 normal young men, approximately matched for age. In the patients with pneumocystis pneumonia lung tissue thickness at the base of the right lung averaged 3.4 cm (71%) more than that in the normal subjects, and interstitial thickness was 1.2 cm (150%) more than in the normal subjects. After treatment 10 of the patients with pneumocystis pneumonia were scanned again. Lung tissue thickness remained greater than the control value by 1.2 cm and interstitial tissue thickness by 0.5 cm. Blood thickness remained unchanged. Lung tissue and interstitial tissue thickness was correlated with a numerical score of the changes in the chest radiograph. The changes in the properties of the lung tissue compartments in the patients presumably reflect the mural and intra-alveolar inflammation found in pneumocystis pneumonia. Transmission scanning alone measures the increase of lung tissue thickness as well as transmission-emission scanning. It may be of value in monitoring the progress of this condition during treatment.

Adult↗
PubMed1988

Surgical management of pneumothorax in cystic fibrosis.

Twenty seven adults with cystic fibrosis who had had either a surgical pleurodesis or pleurectomy for the management of pneumothorax were studied. There were no significant differences in postoperative respiratory function, incidence of recurrent pneumothorax, or incidence of major postoperative complications between the two groups.

Cystic Fibrosis↗
PubMed1986

Pericarditis with pericardial effusion complicating chickenpox.

A girl with chickenpox is presented. She developed arthritis, pericarditis with pericardial effusion and meningism during the course of her illness. Pericarditis is an unusual complication of this disease, and in this instance was associated with characteristic electrocardiographic changes. Aspects of her case history are discussed.

Arthritis, Infectious↗