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Biomedical subjects

D J Sieniewicz

Publications and source records attributed to D J Sieniewicz.

8 recordsLinked to original sources

Conglomerate pulmonary disease: a form of talcosis in intravenous methadone abusers.

A program of detoxification of heroin addicts by the use of oral methadone produced a series of patients who developed pulmonary granulomatous mass lesions as the result of the intravenous use of the oral form of the drug. Talc, used in the preparation of the tablet, seems to be the offending substance. Besides producing a diffuse interstitial granulomatous reaction, conglomerate masses in the upper lung zones were also noted. This radiographic pattern can occur rather rapidly from the background of fine diffuse interstitial micronodularity. The latter may be subtle, but can change to mass lesions associated with lung contraction, volume loss in the upper lung zones, and hyperinflation in the lower lungs. The mechanism of formation of mass lesions is unknown, but individual host reaction and immunologic mechanisms probably play a role. The development and progress of such a process is described in four heroin addicts.

Adult↗

Radiological changes in controlled hypervolaemic pulmonary oedema in dogs.

Chest radiographs taken under ideal conditions and reviewed by a radiologist experienced in looking for pulmonary oedema are an accurate technique for detecting early oedema, differentiating between congestion and oedema, monitoring the increases in oedema up to the stage of alveolar flooding and in determining the effects of CPPV on an oedematous lung. However, ideal conditions do not exist in the I.C.U. Our radiologist had the advantage of a fast exposure, a normal film for comparison in the sequence and only one lesion, conditions unlikely to occur in the I.C.U. It becomes apparent that it is important to obtain the best possible image in these complicated patients. Films in the erect position, for vascular distribution, as well as fast exposures with a high MAS factor give the sharp detail required to best assess lung changes. Serial studies of the chest are a requirement of the I.C.U. patient and it is helpful if comparable films are obtained by using a fixed target-to-film distance in association with the short exposure factors. If this care is taken, chest radiographs are the most accurate non-invasive technique for detecting pulmonary oedema.

Animals↗

Suctioning of the left bronchial tree in critically ill patients.

When suctioning patients with either a tracheostomy or endotracheal tube, the incidence of entry into the left main stem bronchus was recored at the time of routine AP chest examinations in an ICU. The success rate was 8% with an endotracheal tube and 25% when a tracheostomy tube was present; this was lower than has been reported by others. It could reflect the small size of the series or a more accurate picture.

Bronchi↗