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Biomedical subjects

D J Slatkin

Publications and source records attributed to D J Slatkin.

At least 19 recordsLinked to original sources
PubMed1984

Preparation of 7,8-dimethoxy-3,4-dihydroisoquinoline, facile route to 7,8-dioxygenated-3,4-dihydroisoquinolines.

Oxidation of 7,8-dimethoxy-1,2,3,4-tetrahydroisoquinoline with potassium permanganate in acetone afforded 7,8-dimethoxy-3,4-dihydroisoquinoline as the primary product. Hence, oxidation of the appropriate secondary nonphenolic 7,8-dioxygenated tetrahydroisoquinoline alkaloid is thus a facile method for the generation of the corresponding imine. The imine is not easily prepared via the usual synthetic route involving ring closure of beta-phenethylamine derivatives.

Chemical Phenomena↗
PubMed1983

The lack of effectiveness of (-)-epicatechin against alloxan induced diabetes in Wistar rats.

(-)-Epicatechin, a naturally occurring flavonoid, has been reported to protect pancreatic beta cells from alloxan-induced diabetes (1) and to stimulate beta cell regeneration when given after alloxan administration (2,3). However, in the present study, we have not been able to confirm these findings. Administration of (-)-epicatechin (100 mg/kg/day for 15 days) beginning three days after alloxan administration (140 mg/kg) had no significant effect on blood glucose levels when compared to alloxan control animals. Another study which failed to demonstrate an antidiabetic effect of (-)-epicatechin (4) has been criticized for not using fresh solutions of (-)-epicatechin because of its instability in aqueous solution (5). We have found, however, that (-)-epicatechin is stable for at least five days based on thin-layer chromatographic analysis and optical rotation measurements.

Animals↗
PubMed1979

Chemical constituents of Echites hirsuta (Apocynaceae).

A phytochemical investigation of an ethanolic extract of the whole plant of Echites hirsuta (Apocynaceae) resulted in the isolation and identification of the flavonoids naringenin, aromadendrin (dihydrokaempferol), and kaempferol; the coumarin fraxetin; the triterpene ursolic acid; and the sterol glycoside sitosteryl glucoside.

Chromatography, Gel↗
PubMed1978

Anhydrocannabisativine, a new alkaloid from Cannabis sativa L.

Ethanol extracts of the leaves and roots of a Mexican variant of Cannabis sativa L. (marijuana) afforded, after partitioning and chromatography, the new spermidine alkaloid, anhydrocannabisativine. The structure was determined by spectral analysis and semisynthesis.

Alkaloids↗
PubMed1976

Chemical constituents of fruit of Cocculus carolinus D.C. (Menispermaceae).

A phytochemical investigation of an ethanolic extract of the fruit of Cocculus carolinus resulted in the isolation and characterization of the alkaloids, cocculolidine and cocculine. The cyccculine, magnoflorine, and palmatine, previously reported in the stems and leaves of this species, were also isolated and identified.

Alkaloids↗
PubMedDate not supplied

Constituents of West African medicinal plants. XXX. Tridictyophylline, a new morphinan alkaloid from Triclisia dictyophylla.

Triclisia dictyophylla Diels (Menispermaceae) is a woody climber indigenous to West Africa which has been used natively as a medicinal in the treatment of several ailments. Chromatography of an extract of the whole plant afforded tridictophylline (3), a new morphinan alkaloid whose structure was established by a consideration of spectral data and confirmed by x-ray crystallographic analysis. The bisbenzylisoquinoline dibenzodioxin alkaloids cocsuline (1) and trigilletimine (2) were also isolated from the same extract.

Africa, Western↗