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Biomedical subjects

D J Springer

Publications and source records attributed to D J Springer.

9 recordsLinked to original sources
PubMed1999

"Loss prevention".

Explore the source record for details and available documents.

Diagnostic Tests, Routine↗
PubMed1993

Radiologic regression of primary sclerosing cholangitis following combination therapy with an endoprosthesis and ursodeoxycholic acid.

Bile duct strictures seen in patients with primary sclerosing cholangitis are generally considered irreversible. Oral ursodeoxycholic acid therapy has been shown to improve symptoms and biochemical abnormalities, as well as reverse intrahepatic alterations in patients with biliary strictures. Endoscopic therapy also has been effective in relieving symptoms, improving biochemical and radiologic abnormalities, and preventing recurrent cholangitis in patients with primary sclerosing cholangitis. We report a case in which a combination of prolonged endoscopic stenting and oral bile acid therapy resulted in regression of cholangiographic changes and produced a sustained clinical remission.

Adult↗
PubMed1992

Tubular adenoma of the main pancreatic duct.

We report a case of tubular adenoma of the duct of Wirsung with focal villous changes. To our knowledge, this is the 13th reported case of this uncommon neoplasm and the first with a primarily tubular histologic pattern. The patient presented with abdominal pain and diarrhea and was found on endoscopic retrograde cholangiopancreaticography to have a mass in the head of the pancreas, which was confirmed by endoscopic ultrasound. Clinical and pathological features of the 12 previously reported cases are reviewed. Intraoperative testing failed to rule out adenocarcinoma which, in addition to difficulties presented by local anatomic relationships of the tumor, supports wide surgical resection as the preferred surgical solution.

Adenoma↗
PubMed1991

T1-T2 carcinoma of the glottis: relative hypofractionation.

Radiation therapy, the preferred primary treatment for early squamous cell carcinoma of the glottis, offers high local control rates with voice preservation; however, the optimal treatment schedule is subject to debate. Local control, with and without surgical salvage, and associated long-term effects and complications were retrospectively analyzed in 90 patients treated with definitive radiation therapy for T1-T2 squamous cell carcinoma of the glottis. Patients received three weekly fractions of 333 cGy to a total dose of 60 Gy in 6 weeks. Median follow-up was 51.5 months. With radiation therapy alone, local control was 92% for T1 disease and 88% for T2; with surgical salvage, the control rate was 99%. Long-term effects included moderate hoarseness (16% of patients) and moderate or severe laryngeal edema (10% of patients). In seven patients who underwent salvage surgery, the complication rate was 29%. Despite excellent local control, this regimen may produce more long-term effects and complications than conventional fractionation.

Carcinoma, Squamous Cell↗
PubMed1979

A syndrome of acute self-limiting ulcerative esophagitis in young adults probably due to herpes simplex virus.

Five healthy young adults developed an acute self-limiting ulcerative esophagitis. Two had definite evidence of herpes virus being present and a third one had appropriate changes in herpes simplex viral titer. All cases followed a characteristic and similar course consisting of sudden onset of odynophagia, multiple discrete small ulcers in the esophagus and herpetiform lesions elsewhere in the skin or mouth. Although most previous reports of herpes esophagitis indicate that it is an "opportunistic" infection in debilitated hosts, the present report indicates that this infection, in patients who are otherwise well, may occur more frequently than one would have previously suspected. Therefore, herpes simplex virus should be considered as a possible etiological agent in the differential diagnosis in patients presenting with a sudden onset of odynophagia.

Acute Disease↗