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D J van Dyk

Publications and source records attributed to D J van Dyk.

4 recordsLinked to original sources
PubMed1992

Urine uric acid excretion in patients with insulin-dependent diabetes mellitus.

Serum uric acid has been described as being increased in the prediabetic stage of diabetes mellitus and as being decreased in overt diabetes. In this study we compared the serum uric acid levels of patients with insulin-dependent diabetes mellitus (IDDM) to those of controls matched for sex, age and ethnic origin. Also the correlation between serum uric acid levels and the fractional excretion of uric acid in IDDM patients was investigated, as well as the correlation between glycosuria and the fractional excretion of uric acid. The mean serum uric acid was lower in IDDM patients than in normal controls (4.0 +/- 1.3 vs. 4.3 +/- 1.3 mg/100 ml; p less than 0.03), mainly due to significantly lower levels in male and Ashkenazi IDDM patients, as compared to their respective controls. The fractional excretion of uric acid was found to be elevated in IDDM patients: 13.0 +/- 8.6% (mean +/- SD). A significant negative correlation was found between serum uric acid levels and the fractional excretion of uric acid in IDDM patients (p less than 0.001), although not when the males were examined separately. We found no correlation between the fractional excretion of uric acid and the degree of glycosuria in IDDM patients. In addition, the prevalence of hypouricemia (serum uric acid less than 2.5 mg%) was the same in IDDM patients and controls.

Adult↗
PubMed1990

[Peritoneal equilibration test].

7 men and 3 women (mean age 62 +/- 11 years) with end-stage renal disease, who were on continuous ambulatory peritoneal dialysis, underwent a peritoneal equilibration test to determine the rate of peritoneal ultrafiltration and creatinine transfer. The test is based on glucose absorption into the plasma from the peritoneal solution and the diffusion of creatinine into the peritoneal fluid after 2-4 hours. Patients with rapid absorption of glucose have low drain water ultrafiltration volumes but higher creatinine clearances, and therefore need adjustment of the therapy plan or else should be on hemodialysis. No correlation was found between the time the patients were on treatment and glucose absorption or creatinine diffusion.

Aged↗
PubMed1990

Urinary albumin excretion in the healthy population.

In the present study reference values for the albumin excretion rate (AER) and the albumin/creatinine ratio (A/C) in overnight 8-h urine collections (n = 73, group 1) and in 24-h urine collections (n = 25, group 2) were obtained from healthy, nondiabetic, normotensive volunteers. Furthermore, we examined the relationship of these values to age, sex and ethnic group. Albumin was determined by RIA. The mean (+/- SD) values obtained for AER and A/C in overnight urine collections were 6.5 +/- 3.8 mg/24 h and 6.7 +/- 3.6 micrograms/mg creatinine, respectively. These values were significantly lower (P less than 0.001) than the values obtained in 24-h urine collections (AER 11.6 +/- 4.7 mg/24 h and A/C 10.9 +/- 5.0 micrograms/mg creatinine). No difference in AER was observed when the subjects were divided into 10-year age-groups. AER in males was similar to that in females, and AER in European subjects was not different from values obtained for subjects of Oriental (Middle Eastern or North African) origin. Freezing urine specimens resulted in a 25% decrease in AER values. We recommend using freshly obtained 8-h or 24-h urine collections, and considering the excretion of 14 mg/24 h (10 micrograms/min) or 21 mg/24 h (15 micrograms/min), respectively, as the upper limit of normoalbuminuria.

Adult↗