Biomedical subjects
D Janeau
Publications and source records attributed to D Janeau.
[Oculo-cutaneous tyrosinase-positive albinism].
In the present work, the authors discuss the participation of prostaglandins in inflammatory reaction due to U. V. light and the consequences of prostaglandins deficiency. A patient of algerian origin was observed: this 60 year old woman, exhibited an albinism thyrosinase positive and tolerated fairly well an exposure to the U. V. light despite her disease. For ten years she has presented face, neck and arms hyperkeratosis, for five years, arm actinic porokeratosis, and for two years back and face carcinomas. M. E. D. is higher than the standard value. The discussion is open on the fact that this M. E. D. rise might result from prostaglandins deficiency (PE E2 F2). Moreover prostaglandins deficiency increases epidermal multiplication and could account for hyperkeratosis and malignant change, especially so as the patient suffers from albinism and lives in a sunny country. The authors, besides, attempts to relate the other symptoms of this patient to the hypothetical deficiency of prostaglandins; absence of the melanosome maturation, delays in cicatrisation and perhaps immunity perturbations.
[Mammary Paget's disease: an ultrastructural study (author's transl)].
A case of mammary Paget's disease has been studied under electron microscopy. It seems that Paget's cells are coming from the basal layer which is not affected by the malignant proliferation. Paget's cells show some characters of keratinocytes such as rudimentary desmosomes and tonofilaments. But the tumoral tissue is very loose. The Paget's cells are not keratinised; they present numerous vesicles as malignant cells of apocrin mammary carcinoma. There are numerous histogenetic theories of Paget's disease. One of them sounds very interesting: it consists in looking for associations between microscopic mammary Paget's disease and mammary apocrin carcinoma.