Biomedical subjects
Publications and source records attributed to D Janner.
A theoretical and experimental analysis of group velocity reduction in periodic superstructure Bragg gratings is presented. Experimental demonstration of group velocity reduction of sub-nanosecond pulses at the wavelength of optical communications is reported using a Moiré fiber grating.
A theoretical and experimental analysis of beam dynamics and wave packet splitting of light in a periodically bent optical waveguide, a phenomenon recently observed [Phys. Rev. Lett. 94, 073002 (2005)] which is the optical equivalent of adiabatic stabilization of atoms in intense and high-frequency laser fields, is presented in the multimode operational regime. Inhibition of wave packet splitting is theoretically predicted and experimentally observed for higher-order mode excitation.
We report on the first experimental observation of wave packet dichotomy and adiabatic stabilization of light in a periodically bent optical waveguide in analogy with similar behavior of atoms in high-frequency strong laser fields.
We study ray and wave propagation in an elliptical graded-index optical fiber or lens with a twisted axis and show analytically the existence of an instability for both ray trajectories and beam moments in a finite range of axis twist rate embedded within the spatial frequencies of periodically focused rays for the untwisted fiber. By considering the paraxial ray equations and the paraxial wave dynamics in a rotating frame that follows the fiber axis twist, we reduce the dynamical problem of ray trajectories to the classical Blackburn's pendulum, which shows a dynamical instability, corresponding to classical diverging trajectories, due to the competing effects of confining potential, Coriolis force, and centrifugal force. A closed set of linear evolution equations for generalized beam moments are also derived from the paraxial wave equation in the rotating reference frame, revealing the existence of a dynamical moment instability in addition to the trajectory instability. A detailed analysis of beam propagation is presented in case of a Gaussian beam, and different dynamical regimes are discussed.
Wave propagation in an optical waveguide with a bent axis is studied under the scalar and paraxial wave approximations, and the quantum mechanical analogy with the electron dynamics in an atomic potential interacting with an intense electromagnetic field is highlighted. In particular we show that for a truncated parabolic waveguide with a periodically curved axis, a dynamic mode splitting with reduced radiation losses can be observed, which is fully analogous to the phenomenon of wave packet dichotomy and ionization quenching found in strong-field atomic physics.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Two boys presented with variable signs and symptoms of infectious disease that challenged diagnosis. One of the two patients had aortic valve vegetations and lower extremity aneurysms, and the other had calvarial osteomyelitis, epidural abscess, pleural effusions, and pulmonary nodules. Only after a battery of bacterial and fungal agglutination tests was the unsuspected diagnosis made in each of brucellosis from Brucella canis.
Explore the source record for details and available documents.
BACKGROUND: Pediatric skin and skin structure infections are often polymicrobial and require empiric therapy effective against pathogens that may be resistant to many antimicrobial agents. The present study tested the efficacy and safety of a parenteral beta-lactam/beta-lactamase inhibitor combination, ampicillin/sulbactam, and a beta-lactamase-stable cephalosporin, cefuroxime, in serious pediatric skin and skin structure infections requiring hospitalization and parenteral antimicrobial therapy. METHODS: This was a multicenter, randomized, prospective, comparative open label trial that enrolled patients 3 months through 11 years of age. Patients received 150 to 300 mg/kg/day ampicillin/sulbactam in equally divided intravenous doses every 6 h. Cefuroxime was given in a dosage of 50 to 100 mg/kg/day either intravenously or intramuscularly in equally divided doses every 6 or 8 h. Maximum treatment was not to exceed 14 days. Patients could receive subsequent oral antimicrobial treatment at the investigator's discretion. RESULTS: At final evaluation for clinical efficacy, 78.0% (n = 46) of the 59 evaluable patients who received ampicillin/sulbactam were cured and 22.0% (n = 13) were improved. The respective values for the 39 evaluable patients treated with cefuroxime were 76.9% (n = 30) and 23.1% (n = 9). At the end of treatment all pathogens were eradicated from 93.2% (n = 55) of 59 patients treated with ampicillin/sulbactam and from 100% of 39 who received cefuroxime. There were no significant differences between treatments in clinical or bacteriologic efficacy. Both ampicillin/sulbactam and cefuroxime were well-tolerated. CONCLUSION: Both ampicillin/sulbactam and cefuroxime provide safe and effective parenteral antibiotic therapy in pediatric patients with serious skin and skin structure infections.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Although the reported incidence of Pneumocystis carinii pneumonia after heart transplantation in adults ranges from 3% to 40%, data are lacking regarding the incidence in the pediatric heart transplantation population. A retrospective review was performed on 152 infants (0 to 12 months of age) undergoing transplantation from November 1985 through December 1993 who survived at least 6 months after heart transplantation. Patients did not receive postoperative Pneumocystis carinii prophylaxis. Ten episodes (7%) were diagnosed in four neonates and six infants. The mean postoperative time to Pneumocystis carinii diagnosis was 5 months (range 3 to 9 months). Features of Pneumocystis carinii included hypoxia and tachypnea (10 of 10), progressive interstitial infiltrates (8 of 10), and persistent right middle lobe consolidation (1 of 10). Pneumocystis carinii was diagnosed with the use of bronchoscopy in eight cases and by open lung biopsy in two cases. Mean CD4 count available on five patients at the time of Pneumocystis carinii diagnosis was 413/mm3 (range 158 to 1358); 5 of 37 patients receiving antithymocyte induction had Pneumocystis carinii versus 5 of 115 patients who did not receive induction (p = 0.05). Patients were at increased risk for the development of Pneumocystis carinii if they had more than two episodes of rejection during the first year after heart transplantation (p = 0.04). All cases were successfully treated with trimethoprim/sulfamethoxazole. The incidence of Pneumocystis carinii in infant heart transplantation recipients is approximately 7% and appears most frequently in the first 6 months after the operation. Increased risk for Pneumocystis carinii may be related to early antithymocyte induction and increased episodes of rejection.
Explore the source record for details and available documents.