PubMed Health⌕ Search

Biomedical subjects

D Jobin

Publications and source records attributed to D Jobin.

15 recordsLinked to original sources
PubMed1993

[Diagnostic and predictive importance of the blast transformation test and basophil activation test in retinal vasculitis].

22 patients suffering from Birdshot retinochoroidopathy (10), idiopathic vasculitis (6) and Behcet disease (6) and treated by cyclosporine were tested at regular intervals during 11 to 38 months by the lymphocyte stimulation test (LST) and basophil degranulation test (HBDT) with S retinal antigen. These two tests were found frequently positive especially during acute inflammation for the LST. However HBDT was positive in all the patients before relapse of acute inflammation which is in favor of its predictive value and its involvement in the triggering of inflammation at the basophiles or at the local mast cell level.

Basophil Degranulation Test↗
PubMed1991

[Syphilitic uveitis and human immunodeficiency virus infection].

Ocular syphilis is rare in human immunodeficiency virus infected individuals. We think that syphilis should be considered in evaluating such patients presenting with uveitis. Most often, ocular syphilis includes retinitis associated with anterior or posterior uveitis, sometimes with optic neuritis. Concurrent neurosyphilis is frequent and may be more aggressive; it may progress more rapidly and cause more atypical signs than in patients without human immunodeficiency virus infection. This suggests the need for lumbar puncture in the evaluation of coinfected patients. The standard serological tests for syphilis (in blood and cerebrospinal fluid) may be nonreactive in human immunodeficiency virus seropositive patients. It may be because of the alteration of immunologic response of such patients. All coinfected patients with human immunodeficiency virus and syphilis should be treated with high-dose intravenous penicillin G sodium as recommended for neurosyphilis. We describe two human immunodeficiency virus infected patients with ocular syphilis and neurosyphilis.

Acquired Immunodeficiency Syndrome↗
PubMed1990

Severe retinochoroidopathy: variations of humoral and cellular immunity to S-antigen in a longitudinal study.

Ten patients with birdshot retinochoroidopathy, six with isolated retinal vasculitis and eight with Behçet's disease were treated with cyclosporine for one to three years. Autoantibodies to several retinal proteins, circulating lymphocyte subsets and cellular reactivity to S-antigen were evaluated repeatedly during this period. Autoantibody titers were similar in patients and in controls. However the serum content of antibodies to IRBP or S-antigen was lessened during inflammatory periods in some patients. In some sera, antibodies reacted with enzyme digested S-antigen preparations by immunoblot, whereas the same sera were negative for the native protein. A decrease of the CD4+ subpopulation of peripheral blood lymphocytes was associated with relapses of ocular inflammation in birdshot retinochoroidopathy. In this disease and in idiopathic retinal vasculitis, the positive lymphocyte stimulation test and basophil degranulation test with S-antigen were significantly most frequent in the period preceding a relapse of ocular inflammation. These tests could therefore be of predictive value for relapses occurring within the next few months.

Adult↗
PubMed1990

[Keratoplasty in children. Analysis of 127 surgically treated eyes over 10 years].

One hundred and twenty-seven eyes of children less than 15 years of age underwent keratoplasty with one to ten years follow-up. The cases were divided into three groups of age, and the results are compared. Graft transparency has a direct correlation with the age of patient and type of corneal disease. Penetrating keratoplasty carries a better surgical and visual prognosis when carried out late in childhood. This is not only the fact of the particular etiologies found in this subgroup of age. When adjusting the results to the both factors age and etiology, we have demonstrated their independent. The visual benefits of corneal transplantation in selected cases in children appear to outweigh the difficulties and problems engendred by this procedure.

Adolescent↗
PubMed1988

[Results of myopic keratomileusis. A retrospective clinical study apropos of 40 cases].

The authors report in a retrospective study, the results of myopic keratomileusis. 40 eyes were operated on at the department of ophthalmology of Hotel-Dieu Hospital in Paris, with a range follow-up of 6 to 24 months. The mean pre-operative spherical equivalent was - 15.08 +/- 3.32 D., and the mean post-operative spherical equivalent was - 5.02 +/- 3.75 D. relative to preoperative conditions, best corrected visual acuity were unchanged in 6 cases, improved in 16 cases and diminished in 18 cases. The predictability of results was better for patients with myopia in the range of - 9 to - 16 D. During the first post-operative year, a mean regressive tendency of 3 diopters was noted. Complications are reported and analysed. Myopic keratomileusis is indicated for myopia between - 10 and - 16 D., when correction by contact lenses has failed. Candidates for surgery must be informed and consent about possibilities, limits and risks of the procedure.

Cornea↗
PubMedDate not supplied

[Intravenous immunoglobulins and anti-idiotypic suppression of auto-immunity].

This review summarizes the clinical use of intravenous immunoglobulins (IVIg) in autoimmune diseases and focuses on the mechanisms by which IVIg suppress autoimmune responses. Evidence is presented of a role of IVIg in modulating the regulatory function of the idiotypic network on the expression of the natural and pathological autoimmune repertoires.

Autoantibodies↗