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D Jolliffe

Publications and source records attributed to D Jolliffe.

8 recordsLinked to original sources
PubMed2006

A 52-week randomized safety study of a calcipotriol/betamethasone dipropionate two-compound product (Dovobet/Daivobet/Taclonex) in the treatment of psoriasis vulgaris.

BACKGROUND: The calcipotriol/betamethasone dipropionate two-compound product Dovobet/Daivobet/Taclonex(LEO Pharma A/S, Ballerup, Denmark) has been shown to be safe and effective in the treatment of psoriasis for up to 8 weeks. As psoriasis is a chronic disease, long-term treatment may be required, so there is a need to investigate the safety of its use over a longer period of time. OBJECTIVES: To investigate the safety of two treatment regimens involving use of the two-compound product over 52 weeks in the treatment of patients with psoriasis. METHODS: Patients (n = 634) were randomized double-blind to treatment with: (i) 52 weeks of the two-compound product (two-compound group); (ii) 52 weeks of alternating 4-week periods of the two-compound product and calcipotriol (alternating group); or (iii) 4 weeks of the two-compound product followed by 48 weeks of calcipotriol (calcipotriol group). Treatments in all groups were used once daily when required. RESULTS: Adverse drug reactions (ADRs) occurred in 45 (21.7%) patients in the two-compound group, 63 (29.6%) in the alternating group and 78 (37.9%) in the calcipotriol group. The odds ratio for an ADR in the two-compound group relative to the calcipotriol group was 0.46 (95% confidence interval 0.30-0.70; P < 0.001). ADRs of concern associated with long-term topical corticosteroid use occurred in 10 (4.8%) patients in the two-compound group, six (2.8%) in the alternating group and six (2.9%) in the calcipotriol group; those with the highest incidence were skin atrophy, occurring in four (1.9%), one (0.5%) and two (1.0%) patients, respectively, and folliculitis, in three (1.4%), one (0.5%) and no patients, respectively. CONCLUSIONS: Treatment with the two-compound product for up to 52 weeks appears to be safe and well tolerated whether used on its own or alternating every 4 weeks with calcipotriol treatment.

Adult↗
PubMed2004

Extent of overweight among US children and adolescents from 1971 to 2000.

CONTEXT: The prevalence of overweight (OW) among children in the United States has increased during the last three decades, but prevalence measures fail to reveal the extent to which OW children exceed the OW threshold. OBJECTIVE: To measure the amount by which OW children exceed the OW threshold. To examine the trend in this measure over the last three decades using data with measured weights and heights. DESIGN, SETTING AND PARTICIPANTS: Data used for analysis are from the National Health and Nutrition Examination Survey (NHANES) for persons between 2 and 19 y of age from 1971 to 2000. Anthropometric measures were obtained by trained health technicians, and the sample sizes range from 4037 in 1999-2000 to 10,590 in 1988-1994. MAIN OUTCOME MEASURE: The extent of OW is measured as the average amount by which each child's body mass index (BMI) exceeds their age and gender-specific OW threshold. This measure is examined by sex, age group and race/ethnicity. The OW threshold for those aged 2-19 y is defined as at or above the 95th percentile of the sex-specific BMI for age growth charts. RESULTS: The extent of child OW has been increasing faster than the prevalence of child OW for all classifications considered in this paper, including the analysis by age, sex, race and ethnicity. The prevalence of OW for children aged 2-19 y increased by 182% between 1971-1974 and 1999-2000, while the extent of OW increased by 247% over the same time period. CONCLUSIONS: Unlike prevalence measures, the measure of the extent of child OW is sensitive to changes in the BMI distribution of the overweight. This analysis reveals that not only have more children become OW in the last three decades, but OW children have been getting heavier.

Adolescent↗
PubMed2001

The concentration of offenders in families, and family criminality in the prediction of boys' delinquency.

The main aims of this study were to investigate inter-relationships among offending by three generations of relatives (fathers, mothers, sons, daughters, uncles, aunts, grandfathers and grandmothers) and the concentration of offending in families. This study also investigates how far criminal relatives predict a boy's delinquency. The parents of 1395 Pittsburgh boys aged 8, 11 or 14 reported arrests by all relatives. Parent reports of boys' arrests predicted their later referrals to juvenile court, demonstrating predictive validity. Offenders were highly concentrated in families; if one relative had been arrested, there was a high likelihood that another relative had also been arrested. Arrests of relatives were compared with arrests of the boy, court petitions of the boy, and the boy's reported delinquency (according to the parent, boy and teacher). Arrests of brothers, sisters, fathers, mothers, uncles, aunts, grandfathers and grandmothers all predicted the boy's delinquency. The most important relative was the father; arrests of the father predicted the boy's delinquency independently of all other arrested relatives. Studies of explanatory variables suggested that having a young mother, living in a bad neighbourhood, and low guilt of the boy may be links in the causal chain between arrested fathers and delinquent boys.

Adolescent↗
PubMed1999

The spouse as a kidney donor: ethically sound?

A shortage of cadaver donor organs requires transplant units to examine all possible alternatives. Transplantation from living donors accounts for only approximately 10% of kidney transplants in the UK. Recent studies have shown that the results of kidney transplantation between spouses are at least as good as those of well-matched cadaver organs, but very few transplants of this type have been performed in this country so far. As part of the assessment process, the proposed donor and recipient are required to provide written statements about the issues. We reproduce here the personal statements made by one of our patients and his wife: we believe that the statements support our contention that spousal transplantation is ethically justifiable and should be more widely available. We report our early experience in Bristol with seven kidney transplants from spousal donors and we encourage other renal units in this country and elsewhere to consider this method of improving the prospects of kidney transplantation for their patients.

Adult↗
PubMed1998

Comparison of remifentanil in combination with isoflurane or propofol for short-stay surgical procedures.

There are few data in the literature that describe the use of remifentanil when administered as a component of an inhalation or total i.v. anaesthetic (TIVA) technique. We studied 251 male and female patients, aged 18-75 years, ASA I-II, undergoing inguinal hernia repair, arthroscopic knee surgery or varicose vein surgery of at least 30 min duration without premedication. Patients were randomized to receive a remifentanil loading dose of 1.0 microgram kg-1 followed by a continuous infusion of 0.5 microgram kg-1 min-1 in combination with isoflurane (end-tidal concentration 0.6%), (Group I, n = 115) or propofol (initial infusion rate 9 mg kg-1 h-1 reduced to 6 mg kg-1 h-1 after 10 min), (Group P, n = 118). The remifentanil infusion rate was reduced by 50%, 5 min after tracheal intubation. Intraoperative stresses were treated with a remifentanil bolus (1 microgram kg-1) followed by an increase in the remifentanil infusion rate. At the insertion of the last suture, the remifentanil infusion and concomitant anaesthetic were switched off simultaneously. Times to spontaneous respiration, adequate respiration and tracheal extubation were significantly shorter in group I compared with group P (6.4 min vs 7.6 min, P < 0.01; 7.6 min vs 9.3, P < 0.003; 7.8 min vs 9.5 min, P < 0.015). Overall mean systolic blood pressures during surgery were greater in group P compared with group I (P < 0.05) but the absolute differences were clinically insignificant (4-5 mm Hg).

Adolescent↗
PubMed1985

Cardiac effects of sodium stibogluconate.

Sodium stibogluconate although potentially cardiotoxic is the drug of choice for Kalaazar and cutaneous leishmaniasis due to Leishmania braziliensis. Increasing use of this drug in the British Army has necessitated a formal evaluation of its cardiac side-effects. Consequently a detailed study of the cardiac effects of sodium stibogluconate was undertaken in 22 male soldiers using for the first time modern non-invasive techniques. Intravenous sodium stibogluconate 600 mg daily for 10 days did not affect blood pressure, heart rate, left ventricular contractile function or rhythm. Electrocardiography showed a reversible reduction of T wave amplitude.

Adolescent↗