PubMed Health⌕ Search

Biomedical subjects

D Jorgensen

Publications and source records attributed to D Jorgensen.

10 recordsLinked to original sources
PubMed1997

Neonatal Torulopsis glabrata fungemia.

Torulopsis glabrata is a yeastlike fungus that has recently become recognized as an important opportunistic pathogen. Only four cases of T glabrata infection in neonates have been reported. We report two cases of fungemia caused by this organism in premature infants. Both patients were treated with amphotericin B and survived the fungemia, but one patient later died of bacterial sepsis. Both patients had been treated with surfactant, artificial ventilation, intravascular catheters (arterial and venous), broad spectrum antibiotics, and hyperalimentation, which appear to be risk factors for T glabrata fungemia. A review of the literature indicates that T glabrata is susceptible to amphotericin B and 5-fluorocytosine and is resistant to fluconazole. In addition, it is less susceptible to ketoconazole, clotrimazole, and itraconazole than is Candida albicans. We recommend that T glabrata infections be treated initially by reducing iatrogenic risk factors and beginning amphotericin B therapy. If necessary, 5-fluorocytosine should be added to the drug regimen.

Amphotericin B↗
PubMed1987

The effects of selenium on the distribution of mercury in the organs of the black bullhead (Ictalurus melas).

Following i.p. mercuric chloride injections, the mercury was deposited primarily in the kidneys. Simultaneous selenium injections prevented mercury induced osmoregulatory failure even though selenium strongly promoted the movement of mercury to the kidneys and its deposition in an approximate 1:1 mercuric selenite ratio. Whole-body retention of mercury was not altered by simultaneous subcutaneous injections of sodium selenite.

Animals↗
PubMed1979

Axonal underdevelopment from axotomy in kittens.

Permanent axotomy, by hind limb amputation in kittens, is found by morphometric evaluation at 9 months after amputation to result in failure of ventral and dorsal root myelinated fibers (MFs) to attain adult calibers. The positions of the median diameter and of diameter peaks were unequivocally displaced to smaller diameters, but more so for dorsal than for ventral roots. When fiber spectra of amputated roots were compared with those of kittens at the time of amputation, the median diameter, the position of peaks of diameter histograms, and the diameters of largest MFs were clearly at larger diameters, an indication that axonal development had continued (especially for motor fibers) for some time after amputation. These studies have shown that whereas in adult cats, permanent axotomy results in axonal atrophy, in kittens axonal development continues, but stops short of reaching adult values. As axonal caliber presumably ultimately relates to perikaryal synthesis of protein, one must infer either that the signal to decrease protein synthesis is slow in arriving at the perikarya or that the decreased axonal flow of materials resulting from such a signal is slow and thus allows continued axonal growth for a period after amputation.

Amputation, Surgical↗