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Biomedical subjects

D Jurkovic

Publications and source records attributed to D Jurkovic.

99 records · Page 6Linked to original sources
PubMed1991

Ovarian morphology, endocrine function and intra-follicular blood flow during the peri-ovulatory period.

Transvaginal ultrasonography with colour flow mapping has been used to study changes in intra-follicular morphology and blood flow during a peri-ovulatory period in one volunteer. Aspects of uterine morphology and blood flow were also recorded. The intervals from a defined luteinizing hormone (LH) rise and peak to the mean time of follicular rupture were 37.5 and 17.5 h, respectively. Blood flow velocity waveforms were observed clearly at the time of the LH rise and blood vessels were visible when the hormone level reached a peak. Concurrently, the wall of the follicle became less clear, crenated, thicker and more echogenic. A structure resembling the detached cumulus and oocyte was seen before the follicle had ruptured. Peak systolic blood velocity was highest immediately after ovulation had occurred. Blood flow impedance in the uterine arteries suggested the presence of a circadian rhythm, but no pronounced daily changes were observed over the study period. In contrast, flow velocity waveforms were clearly visible in the endometrium around the time of ovulation. These preliminary data suggest that intra-follicular vascularization or angiogenesis may be critical processes that might be used to predict ovulation and could possibly be modified to help achieve or avoid a pregnancy.

Adult↗
PubMed1991

Development of the secondary human yolk sac: correlation of sonographic and anatomical features.

Transvaginal ultrasound examination of the secondary yolk sac was performed in 145 first trimester pregnancies with a normal outcome (Group A), in 10 normal pregnancies undergoing artificial termination (Group B) and in 25 pregnancies that subsequently failed (Group C) due to embryonic death (n = 17) or to spontaneous abortion of a live embryo (n = 8). The yolk sac structure of all cases from Group B and from 12 cases of Group C were examined morphologically, in order to investigate the changes secondary to normal yolk sac senescence or to pregnancy complication and to evaluate the relationship existing between these changes and ultrasound features. The yolk sac diameter measured in vivo increased significantly between 6 and 10 weeks of gestation and then decreased significantly. Morphologically, the yolk sac showed degenerative changes after 9 weeks of gestation suggesting that the disappearance of the yolk sac in normal pregnancies was a spontaneous event of embryonic development rather than the result of mechanical compression by the expanding amniotic cavity. Yolk sac measurements in complicated pregnancies were not predictive of pregnancy outcome. Irrespective of gestational age, important degenerative changes were found in pregnancies complicated by embryonic death or disappearance, suggesting that variation of yolk sac size and appearance in these cases is the consequence of abnormal embryonic development of death rather than being the primary cause of early pregnancy failure.

Cytoplasm↗
PubMed1991

Biochemical composition of exocoelomic fluid in early human pregnancy.

Exocoelomic fluid (N = 25) and amniotic fluid (AF) (N = 17) were retrieved by transvaginal puncture from 30 normal pregnancies being terminated for psychosocial reasons between 5-13 weeks of gestation. Biochemical analyses were performed on each sample including concentrations of urea, total protein, potassium, sodium, creatinine, hCG, and alpha-fetoprotein (AFP). The results were compared with values in maternal serum obtained at the same time. Significant correlations were found between gestational age and concentrations of urea (P less than .005), total protein (P less than .05), and hCG (P less than .001) in the exocoelomic fluid. Significantly (P less than .05) higher total protein levels were found in the exocoelomic fluid during the third month of pregnancy compared with the second month. Urea concentration and hCG levels were significantly (P less than .005 and P less than .001, respectively) lower in the exocoelomic fluid during the third than during the second month of gestation. Significantly higher protein (P less than .001 and P less than .001), potassium (P less than .005 and P less than .05), sodium (P less than .001 and P less than .05), and creatinine (P less than .01 and P less than .001) concentrations were found in the maternal serum compared with exocoelomic fluid and AF, respectively. The concentration of hCG was significantly (P less than .001) higher in exocoelomic fluid and significantly (P less than .001) lower in AF than in maternal serum. The AFP level was significantly (both P less than .001) lower in the maternal serum than in both fluids.(ABSTRACT TRUNCATED AT 250 WORDS)

Amniotic Fluid↗
PubMed1991

Transvaginal color Doppler assessment of the uteroplacental circulation in early pregnancy.

Transvaginal color Doppler was used to investigate the uteroplacental circulation of 45 patients with normal intrauterine pregnancies at 4-18 weeks' gestation. The main uterine artery and the radial and spiral arteries were demonstrated, and characteristic flow velocity waveforms were obtained in more than 90% of cases. The indices of impedance to flow decreased with gestation and there was a progressive fall in these indices from the uterine artery, through the radial, to the spiral artery. Blood velocity in the uterine artery increased exponentially with gestation.

Adult↗
PubMed1990

Transvaginal color Doppler imaging.

Transvaginal color Doppler was used to assess circulation in pelvic vessels in a group of 64 patients including 15 patients with fertility problems, 18 patients with pelvic tumors, 2 cases of suspected ectopic pregnancy, and 29 pregnant patients with fetuses between 6 weeks and 10 weeks, menstrual age. Blood flow was successfully displayed by color Doppler in the external and internal iliac arteries, and the uterine arteries, but flow in ovarian arteries could not be visualized. In the subgroup of patients with pelvic tumors, neovascularization of tumor tissue was documented in 6 out of 10 cases of uterine fibroma and in 2 cases of ovarian cancer. In 6 cases involving benign ovarian pathology, no abnormal blood supply was observed. A comparison between the characteristics of blood flow within uterine fibromas and ovarian malignancies showed lower impedance and higher blood velocity in cases of malignancy. In early pregnancy blood flow in the umbilical artery could be visualized by color Doppler starting from the 6th week and flow in the aorta from the 8th week. Flow in the trophoblasts was observed with an overall success rate of 59% and successfully demonstrated in 1 out of 2 cases of ectopic pregnancy.

Blood Flow Velocity↗
PubMed1989

Contribution to the recognition of iniencephaly on the basis of a new case.

A child at term had been delivered by means of Caesarean operation because of its I. dorso-superior transverse position. The not viable, female newborn had a malformation causing an extremely retroflexion of the head. After intensive pathological and anatomical study the main diagnosis was iniencephaly and heart malformation. A large number of further results, also of malformated brain anatomy is given to contribute to the knowledge of the malformation sequence. The chances for early detection of the malformation are discussed.

Abnormalities, Multiple↗
PubMed1987

Ultrasonically guided fetal tissue biopsy.

From January 1984 to October 1986, a total of 185 prenatal diagnostic procedures were performed, viz. 120 chorionic villus samplings, 42 fetal blood samplings, 12 skin biopsies and 11 tumor biopsies. All procedures were performed under continuous ultrasound guidance. The methods are described, and indications for each procedure and clinical outcome discussed. Preliminary results have shown that ultrasonically guided fetal tissue biopsy is feasible for prenatal diagnosis, but randomized trials are needed for evaluation of the risk/benefit ratio.

Biopsy, Needle↗