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Biomedical subjects

D K Drake

Publications and source records attributed to D K Drake.

4 recordsLinked to original sources
PubMed1994

Recognition and management of heat-related illness.

Health care providers are challenged to recognize heat-related illness in a variety of settings--episodic office visits, acute emergency room visits, telephone advice calls, and in the community at local sporting events and social functions. In order to determine the cause and initiate appropriate management, the provider must realize the spectrum of heat-related illness, understand normal and abnormal thermoregulation, identify populations at risk, and identify treatment. The spectrum includes heat rash, heat edema, heat cramps, heat exhaustion, and heatstroke. Heatstroke is a medical emergency with a body temperature elevation of 40.5 degrees C or greater and cardiovascular and neurologic compromise that can result in death. Patient education is aimed at preventative measures to ward off recurrent heat-related illness, especially heat exhaustion and heat stroke.

Body Temperature↗
PubMed1987

Neuro-oncology update: radiation safety and nursing care during interstitial brachytherapy.

Radiation control and safety are major considerations for nursing personnel during the care of patients receiving brachytherapy. Since the theory and practice of radiation applications are not part of the routine curriculum of nursing programs, the education of nurses and other health care professionals in radiation safety procedures is important. Regulatory agencies recommend that an annual safety course be given to all persons frequenting, using, or associated with patients containing radioactive materials. This article presents pertinent aspects of the principles and procedures of radiation safety, the role of personnel dose-monitoring devices, and the value of additional radiation control features, such as a lead cubicle, during interstitial brain implants. One institution's protocol and procedures for the care of high-intensity iridium-192 brain implants are discussed. Preoperative teaching guidelines and nursing interventions included in the protocol focus on radiation control principles.

Astrocytoma↗
PubMed1982

Identification and purification of an endogenous receptor for the lectin pallidin from Polysphondylium pallidum.

We report the identification and purification of an endogenous carbohydrate-containing receptor of pallidin, the cell surface lectin implicated in mediating cell-cell adhesion in the cellular slime mold Polysphondylium pallidum. The receptor is identified in an aqueous extract of crude P. pallidum membranes as a potent inhibitor of the hemagglutination activity of pallidin. The inhibitor is purified to apparent homogeneity by affinity precipitation with pallidin followed by fractionation of the solubilized precipitate on Sepharose 4B. The hemagglutination inhibitor (HAI) is metabolically radiolabeled, indicating that it is a biosynthetic product of the amoebae and not an ingested food substance. The HAI is released into the extracellular medium by living, differentiated amoebae. This release is markedly facilitated by the addition of D-galactose, a specific saccharide that binds to pallidin. Hence, the HAI appears to have an in situ association with pallidin at the cell surface. Exogenously added HAI promotes the agglutination of differentiated amoebae in a gyrated suspension at very low concentrations. The results are consistent with a model of cell-cell adhesion in which the HAI is a multivalent, extracellular aggregation factor that is recognized by pallidin molecules on adjacent cells. The HAI would then be analogues to the aggregation factors identified in marine sponges.

Adhesiveness↗