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Biomedical subjects

D K Ford

Publications and source records attributed to D K Ford.

13 recordsLinked to original sources
PubMed1979

Studies on vaccine-induced rubella arthritis. Serologic findings before and after immunization.

Rubella hemagglutination inhibition (HI) antibody responses were measured before and after immunization with HPV-77 DE/5 vaccine in 7 adult females with recurrent arthritis following rubella immunization and 24 hospital personnel studied prospectively while undergoing routine rubella immunization. The only distinctive serologic characteristic observed in all subjects developing rubella arthritis was a preimmunization HI titer of less than 1 : 8. No association was observed between the development of arthritis after immunization and prolongation of rubella HI IgM responses or elevation of rubella HI IgG responses.

Adult↗
PubMed1979

The clinical spectrum of Reiter's syndrome and similar postenteric arthropathies.

Certain infections of the genitourinary and gastrointestinal tracts, such as nongonococcal urethritis, dysentery and yersiniosis, precipitate characteristic arthritic syndromes in genetically susceptible individuals. Eye and skin lesions in the form of conjunctivitis, iritis, keratodermia blenorrhagica and erythema nodosum occurring in association with particular distributions of arthritis make recognizable clinical entities. Reiter's syndrome may be diagnosed with certainty from the presence of tender heels, low back pain, a predominance of knee and foot arthritis and pyuria, when the more obvious clinical markers of the syndrome are absent; a flagrant case represents one of the easiest clinical diagnoses in medicine. Diagnosis is important for a good prognosis, optimal treatment and sometimes prophylactic measures. Sacroiliitis often progressing to spinal ankylosis is a prominant feature in the B27-positive patient. Erythema nodosum occurs in B27-negative subjects as a response to yersiniosis and ulcerative colitis.

Arthritis↗
PubMed1978

Synthesis by an established lymphocyte cell line from a rheumatoid synovium.

Lymphocytes derived from the synovium of a patient with rheumatoid arthritis were shown to synthesize predominantly IgG as measured by an equilibrium binding assay. Chromatographic separation of the radiolabeled lymphocyte culture supernatant revealed rheumatoid factor activity associated with IgG and IgM. In addition, immunofluorescence studies on fixed lymphocytes demonstrated that the majority of cells stained positive for both IgG and rheumatoid factor.

Arthritis, Rheumatoid↗
PubMed1977

D-penicillamine in the treatment of rheumatoid arthritis.

Forty-four patients with definite or classic rheumatoid arthritis and failure to tolerate or respond to gold therapy were treated with D-penicillamine on a so-called go-slow, go-low regime. Seventeen patients tolerated the drug and had a 3-13 month follow-up assessment; 8 were markedly improved, 6 moderately or slightly improved, and 3 unimproved. Penicillamine had to be discontinued in 9 patients because of toxic side effects.

Aged↗
PubMedDate not supplied

Serum antibody levels against T mycoplasmas in two North American Indian populations predisposed to spondylitis.

Serum antibody levels against T mycoplasmas (Ureaplasma urealyticum) were determined by the metabolic inhibition method in several populations. A higher prevalence of antibody was found in Haida Indians and Bella Coola Indians than in blood donors, patients with rheumatoid arthritis, and patients attending a VD clinic. Antibody levels did not correlate with the presence of spodylitis or the histocompatibility antigen HLA-B27, although both these Indian populations have a high prevalence of spondylitis and HLA-B27.

Antibodies, Bacterial↗
PubMedDate not supplied

Yersinia-related arthritis in the Pacific Northwest.

Serologic evidence of Yersinia enterocolitica infection was sought by agglutination testing in serum samples from several populations, including Haida Indians, Red Cross blood donors, and Caucasian patients with rheumatoid arthritis, ankylosing spondylitis, and Reiter's syndrome. No evidence was found to indicate that yersinial infection was etiologically related to Haida spondylitis or Reiter's syndrome. Four of 28 patients with acute arthritis were diagnosed from serologic evidence as having Yersinia-related arthritis.

Adult↗