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Biomedical subjects

D K Goette

Publications and source records attributed to D K Goette.

At least 19 recordsLinked to original sources
PubMed1979

Erythema multiforme and urticaria. Eruptions induced by chemically related ophthalmic anticholinergic agents.

Erythema multiforme developed in an 80-year-old man following the use of scopolamine hydrobromide ophthalmic drops. The erythema multiforme cleared when the medication was discontinued and recurred on challenge. Later, he was given tropicamide, an anticholinergic ophthalmic preparation that, like scopolamine, has a tropic acid residue. Within 15 minutes an immediate hypersensitivity reaction with generalized urticaria developed in the patient.

Aged↗
PubMed1979

Adverse effects of corticosteroids.

The introduction of corticosteroids has constitutded the most revolutionary event in dermatologic therapy in the last twenty-five years. The effectiveness of topical therapy in well diagnosed and obscure dermatoses led to wide applications by specialists and general practitioners, and resulted in the development of more potent topical steroid preparations. Their enthusiastic acceptance, and often indiscriminante use, has been followed by occasional reports of adverse effects. After the introduction of occlusive topical steroid therapy under plastic wrap, more dramatic therapeutic effects were achieved, but the adverse effects also increased. There is presently an abundance of reports elaborating on systemic and local adverse reactions resulting from topically applied or intralesionally injected steroids. This report summarizes the local side effects of these steroids.

Administration, Topical↗
PubMed1979

Localized eosinophilic fasciitis.

Two patients developed an erythematous, rock-hard induration of their forearms after strenuous physical activity. Peripheral eosinophilia was noted in one patient, but hypergammaglobulinemia was absent. Systemic corticosteroid treatment resulted in remarkable involution of the process in one patient, while the other experienced spontaneous involution. The histologic changes were those of eosinophilic fasciitis.

Diagnosis, Differential↗
PubMed1978

Late benign syphilis of the skin.

Two cases of late cutaneous syphilis are presented. After treatment for secondary syphilis in 1957 and retreatment for rising VDRL titers ten years later, one patient had developed a nodular syphilid. The other had several gummas. He had two quantitative nonreactive vDRL tests and a negative Treponema pallidum immobilization (TPI) test, but two reactive fluorescent treponemal antibody absorption (FTA-ABS) tests. Syphilis was suspected histologically and was confirmed by the specific serologic testing, the characteristic clinical presentation, and the prompt response to penicillin treatment. The clinical, serologic, histologic, therapeutic, and pathogenetic aspects of late benign syphilis of the skin are discussed.

Adult↗
PubMed1978

Erythema chronicum migrans in three soldiers.

Three cases of erythema chronicum migrans in soldiers who had returned from active duty in Central Europe were seen within a ten-week period in San Franciso. Typically, the lesions cleared in less than five days with penicillin in two cases and erythromycin in another.

Adult↗
PubMed1978

Primary inoculation tuberculosis of the skin. Prosector's paronychia,.

Subsequent to an autopsy of a tuberculotic cadaver, a pathology resident presented with a painless paronychia and axillary adenopathy after surgical incision and broad-spectrum antibiotics had failed to improve his condition. Demonstration by culture of Mycobacterium tuberculosis var hominis, positive smears, and findings of acid-fast organisms in a skin biopsy specimen proved the diagnosis of tuberculosis. Conversion of a previously negative skin test permitted the diagnosis of primary inoculation tuberculosis of the skin. The disease responded well to treatment with isoniazid, rifampin, and pyridoxine hydrochloride.

Adult↗
PubMed1978

Treatment of cutaneous Kaposi's sarcoma with intralesional vincristine.

A 68-year-old man had lesions of Kaposi's sarcoma that developed continually in a localized area after excisional surgery, electrosurgery, and radiotherapy of previous lesions. His lesions cleared with intralesional injections of vincristine sulfate without any systemic and only minor local side effects. Newly developed lesions, which did not occur on the sites of previous treatment, were also responsive to this form of therapy.

Aged↗
PubMed1978

Treatment of keratoacanthomas with intralesional fluorouracil.

Fourteen patients with 26 keratoacanthomas (KA) were treated weekly with intralesional injections of fluorouracil. Twenty-five lesions cleared in an average of three weeks (range, two to eight weeks) after an average of 2.8 injections. One KA failed to respond after five weekly injections and was excised. No recurrences or meaningful side effects were observed. It appears that treatment of KA with intralesional fluorouracil injections is a safe, effective, and convenient mode ot treatment yielding excellent cosmetic results.

Aged↗
PubMed1977

Perforating granuloma annualare.

Described is a 37-year-old male patient with signs and symptoms of localized perforating granuloma annulare (PGA) on the dorsa of his hands, fingers, elbows, and extensor forearms. PGA usually occurs primarily on the extremities, but the condition may be generalized. Review of the literature indicates that the cause and pathogenesis of this entity remain obscure. Sunlight may exacerbate PGA. Therapeutic success has been obtained with topical steroids with occlusion and with systemic prednisone. Our patient showed no response to liquid nitrogen but responded satisfactorily to topical steroids with occlusion.

Adult↗
PubMed1977

Skin blanching induced by hydrogen peroxide.

Transitory blanching of nonacral skin has been observed after contact with a 3% solution of H2O2. This phenomenon was reproducible in all tested whites, but was not reproducible in black skin. Blanching developed within 30 to 300 seconds after contact with H2O2 and lasted from 10 to 30 minutes. It is proposed that the topical application of H2O2 induces a transient vasoconstriction of vessels in the superficial dermis.

Adult↗
PubMed1977

Pyogenic granuloma of the oral cavity.

A case of pyogenic granuloma on the tongue of a woman who was seven months pregnant is reported. A brief review of the literature is given along with suggestions for the management of similar cases.

Adult↗
PubMed1977

Allergic contact dermatitis from topical fluorouracil.

An allergic contact dermatitis from fluorouracil developed in two patients 8 and 18 days respectively after institution of topical fluorouracil therapy. The character of the usual irritant dermatitis changed to that of an allergic dermatitis. Epicutaneous patch tests and intradermal tests with fluorourcil were reactive. Histologic specimens of positive test sites revealed the changes expected in allergic contact dermatitis. Twelve control subjects failed to react to intradermal fluorouracil tests.

Administration, Topical↗
PubMed1977

Allergic contact dermatitis to topical fluorouracil.

We designed a prospective and retrospective study to determine the incidence of allergic contact dermatitis to topical application of fluorouracil. Intracutaneous and epicutaneous skin tests of various fluorouracil concentrations were given to patients who were to be treated with the drug for actinic keratoses (group A) and to patients who had previously been treated with fluorouracil for actinic keratoses (group B). Six patients in group B had allergic contact dermatitis to topical fluorouracil. The common clinical characteristic of the six patients was a severe pruritic eruption at the site of fluorouracil application. Allergic contact dermatitis should be suspected in the presence of severe pruritus or a severe eczematous response in patients treated with topical fluorouracil.

California↗