On the theory of interfacial double-layer potential differences and periaxonal accumulation of potassium in squid giant axons.
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Biomedical subjects
Publications and source records attributed to D K McIlroy.
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The theoretical pH dependence of enzyme activities in membranes of low dielectric constant is estimated. It is shown that in biological membranes some types of enzymes may attain a limiting pH sensitivity such that an increment of only 0.2 pH unit (sufficient to induce action potentials in squid axons) causes a relative activity change of over 25%. The transients of enzyme activity generated by membrane depolarization and by pH increments in the bathing solution are discussed in relation to the transients of nervous excitation.