[The EEG in slight to moderate traumatic cerebral damage in childhood (author's transl)].
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Biomedical subjects
Publications and source records attributed to D Kömpf.
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Most studies on event-related EEG potentials in dementia have focussed on the P3 component and used auditory stimuli only. In the present study, N2b was analysed in the usual auditory oddball task in addition to P3, and a visual task was employed ("Push"/"Wait"), with recordings including an occipital scalp site. Seven Alzheimer-type patients, with their mean IQ still in the normal range, were compared to age-matched normal controls. In the oddball task, P3 did not differ between groups but the patients' N2b was delayed. The main difference in the Push/Wait task was in an occipital P270, which component was distinctly larger in the patients. It is suggested that both differences reflect the disintegration of patients' cognition: stimuli are perceived in a normal way but then a gap arises due to uncertainty what to do with the perceived event.
Patients with dementia of the Alzheimer type (DAT) are described to have disturbances in basic visual, complex visual and oculomotor functions. In order to study and quantify dysfunction of eye movements under several paradigms, they were measured with infrared photoelectric techniques and analyzed by a digital computer. The study included 12 normal subjects and 10 patients with mild to moderate DAT (DSM-III-R criteria). The authors' results could demonstrate both an attentional deficit to externally triggered, unpredictable targets and an impaired systematic, voluntary, internally organized scanning of the environment due to motivational and perceptional deficits.