[Treatment of vitiligo using oral Trisoralen].
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Biomedical subjects
Publications and source records attributed to D Karadaglić.
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The ultrastructural analysis of psoriatic dermal lesions has shown the alteration of the dermal arterioles into specialized postcapillary venules, the so called high endothelial venules (HEV) which are characterized by the presence of tannic acid staining materials (TASM) located among the endothelial cells. This type of venules seen in the lymphatic nodes and other lymphoid organs is considered to be an important site of lymphocyte recirculation. Similar venules are seen in the lymphatic nodes too. In correlation with the immunologic evidences in the lymphoid tissues and in psoriasis most probably in question are the identical surface antigen-lymphocyte receptors on the HVE which support selective binding of the definite subset of lymphocytes and migration from blood to tissues.
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The use of electron microscope in the study of the diseased skin of four patients with Alopecia areata has detected changes in the endothelial cells with narrowed capillary lumen. The authors have brought these findings in connection with the decreased blood circulation in lesions of patients with Alopecia areata which necessiates the use of vasodilatator agents in their therapy. Etiopathogenesis of the disease has been discussed.
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