PubMed Health⌕ Search

Biomedical subjects

D Kaskarelis

Publications and source records attributed to D Kaskarelis.

45 records · Page 3Linked to original sources
PubMedDate not supplied

Selective survival of only the healthy fetus following prenatal diagnosis of thalassaemia major in binovular twin gestation.

Selective feticide is the procedure of choice when, in twin binovular pregnancy, only one of the fetuses is shown to be affected. As the probabilities for this condition are almost 1:2 when the genetic disease is due to homozygosity for two autosomal recessive genes, the problem is expected to occur frequently among the ever increasing number of couples seeking prenatal diagnosis of thalassaemia and the haemoglobinopathies. The present report is the first case of this condition and the ninth in the overall medical literature.

Abortion, Eugenic↗
PubMedDate not supplied

Induction of abortion by intra-amniotic administration of prostaglandin F2 alpha in patients with intrauterine fetal death and missed abortion.

The use of intra-amniotic administration of Prostaglandin (PG) F2 alpha in the management of intrauterine fetal death and missed abortion is evaluated in a series of 30 patients. The patients were from 17 to 38 years of age with a median of 25 years. Parity ranged from 0 to three, and duration of gestation ranged from 16 to 37 weeks, with a median of 24 weeks. A single intra-amniotic dose of 40 mg PGF2 alpha was used under direct ultrasound vision. Induction was achieved in all cases. There were 28 complete, and two incomplete terminations. The mean treatment to completion interval for all patients was 5.3 hours. Side effects were minimal: we believe that PGF2 alpha can be safely administered intra-amniotically even with a dead fetus in the uterus and that it can lead to abortion with a minimum of discomfort and danger to the mother.

Abortion, Induced↗
PubMedDate not supplied

[Clindamycin levels in the cervical mucus after intramuscular administration of the drug (author's transl)].

Female genital tract is a major area of anaerobic infections. Clindamycin has been used as a highly active antibiotic against both gram positive and negative anaerobic pathogens including bacteroides fragilis. Concentration of clindamycin in cervical mucus has been tested in 30 women after administration of one single dose (600 mg) of the antibiotic intramuscularly. Antibiotic levels were tested by agar diffusion method employing a strain of alpha-hemolytic streptococcus. Levels of clindamycin in cervical mucus were found to be sufficient to inhibit "in vitro" a significant proportion of anaerobic bacteria present in cervical mucus.

Cervix Mucus↗
PubMedDate not supplied

The use of 15-methylated derivative of prostaglandin F2a for the therapeutic termination of pregnancy and management of late fetal death.

The administration of 15-me-PGF 2a for the therapeutic termination of pregnancy and management of intrauterine death of the embryo during the second and third trimester of pregnancy was studied in 92 patients. Of these, 52 came because of intrauterine death with an average gestational age of 28.7 weeks while the rest came for therapeutic termination of pregnancy with an average gestational age of 21 weeks. Successful abortion was achieved in 90 patients. The mean abortion induction time was 7.3 hours for patients with intrauterine death and 12.6 hours for the patients who came for therapeutic termination. The results and complications of the intramuscular administration of the 15-me-PFG2a are analysed in the present work.

Abortion, Induced↗
PubMedDate not supplied

Ectopic pregnancy: outcome of 152 cases.

Ectopic pregnancy is a common gynecological condition which usually presents with symptoms of acute abdomen. During the period 1976 to 1978, 152 cases of ectopic pregnancy were treated in our department. About one ectopic pregnancy was treated for every 100 infants delivered. Most of the cases were seen during summer time. Of the patients 43% were between 26 to 30 years of age. From their previous history, 47% reported one or more terminations of pregnancy and 33% recurrence of acute salpingitis. The majority of the ectopic pregnancies were located in the tube. Abdominal pregnancy was observed in three women, one of whom delivered, with the aid of laparotomy, a live infant. All the women reported pelvic pain, whereas shock appeared in only 23% of the cases. Culdocentesis gave false negative results in 14.15% of the cases. Preoperative diagnosis was based on laparoscopy in 28 cases. Dilatation and curettage (D and C) with endometrial biopsy disclosed decidual endometrium without chorionic villi in 37% and Arias-Stella cells in 68% of cases. Salpingectomy was performed in 52% of the cases, and plastic surgery of the tube in 16%.

Adolescent↗