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Biomedical subjects

D Kettler

Publications and source records attributed to D Kettler.

At least 37 records · Page 2Linked to original sources
PubMed1999

Involvement of an anaesthetic department in terminal therapy.

The goal of hospital treatment in terminal therapy must be a functional integration of all modes of care including psychosocial support. Anaesthesiologists who practise pain management and critical care medicine are predestined to care for terminally ill patients and their families. An anaesthetic department can assume superordinate responsibilities within the organization of a palliative network coordinating inpatient and outpatient arrangements.

Journal Article↗
PubMed1999

[Emergency and intensive care medicine as an interdisciplinary training requirement].

While substantial and practical qualification for medical practice within the framework of emergency medical services have to be proven by an advanced training, there are no special training programs for in-hospital emergency situations. As in the emergency room a transparent in-hospital emergency management has to be established including definite competencies to avoid time delays and inadequate treatment due to disputes about competence. Especially surgical intensive care medicine is an interdisciplinary task, requiring the participation of the surgeon as a responsible partner. Thus, the physician working in ICUs needs professional qualification and specialized knowledge as well as marked competence to co-operate. In any case the final clinical responsibility has to be taken over by physicians who not only have performed their internship on a ICU but are highly qualified in the whole range of intensive care medicine including all topics required in advanced intensive care medicine curricula.

Clinical Competence↗
PubMed1998

[Causes of failure and dangers in the use of motor driven infusion pumps. Accidental closure of the infusion system].

UNLABELLED: Syringe drivers are used in anaesthetics, intensive care and emergency medicine to deliver small volumes of highly potent drugs with continuous, constant and reproducible flow. For early recognition of interruptions of the drug delivery caused by occlusion of the infusion system, an alarm is triggered as soon as the system pressure exceeds a certain limit. The sensitivity of this alarm depends on the flow rate, type-specific cut-off pressure and the elastic parameters of the infusion system. The sudden release of pressure built up in the system after occlusion occurred can cause delivery of an uncontrolled drug bolus and hence an additional hazard. METHODS: Six syringe drivers that are widely used in clinical practice were tested for alarm delay and bolus delivery in the event of an occlusion in the system. First, the alarm pressures at flow rates of 10, 50 and 100 ml/h were measured. Then the alarm delay time and bolus volumes post-occlusion were assessed, using a basic infusion system (syringe + single infusion set). Finally, several alterations to the system like extension, tap battery with germ filters or branching were made and their impact on alarm delay and bolus volume measured. RESULTS: Because of the great differences in alarm pressures between the devices tested, there were marked differences in the alarm delay at same flow rates. Predictably, there was an indirect proportional link between alarm delay and flow rate. Using the basic infusion system, alarm delays between 23 s and 143 min were measured. In two of the tested syringe drivers, a pressure-release mechanism is activated with the pressure alarm, which prevented bolus application. In the other devices, release of the pressure in the occluded system caused boli of 0.5-7 ml. Variations in the actual syringe volume and insertion of a second connection tube had no impact on alarm delay and bolus volume. Tap batteries, parallel running syringe drivers or trapped air in the system, however, caused marked increase in both alarm delay (107%) and bolus volume (+147%). DISCUSSION: Unidentified occlusions of the system cause grave malfunctioning of syringe drivers. While applying highly potent drugs, the discontinuation of drug delivery with subsequent bolus application can cause vital danger to the patient. As a result of the significant time delays in the pressure alarms, the devices tested do not provide sufficient protection against unrecognized system occlusion. Syringe drivers with adjustable alarm pressure can be set close to the actual infusion pressure. A further important point is that one should aim at a reduction in the elastic properties of the infusion set because of the great impact on alarm delay and bolus volume.

Equipment Failure↗
PubMed1998

[Ethical challenges in preclinical emergency medicine].

Out-of-hospital emergency medicine, just like any other medical field, must be guided by general ethical principles of medical action. These include respecting the patient's autonomous decision, acting for his benefit, avoiding harm, and justice in distributing the available means. The confrontation with ethical conflicts in the routine of emergency medicine is illustrated by a case report. The emergency physician, called to a 76-year-old patient with circulatory arrest, decides against starting a resuscitation attempt. His decision is based on the fact that at least 15 minutes had passed from the cardiac arrest till the arrival of the emergency care team, on the previously existing, severe cardiac disease, on the age of the patient, on family statements of patient's refusal of resuscitation and on the clinical findings of fixed, dilated pupils, missing brainstem reflexes, and an asystole as an initially recorded cardiac rhythm. No certain clinical signs of death could be observed. In the face of this combination of conditions unfavourable for a successful resuscitation attempt and a survival of the patient, the emergency physician assumes an obvious futility of medical action. The individual criteria are analysed with respect to their prognostic value for estimating the chances of surviving out-of-hospital circulatory arrest. In the context of resuscitation attempts, the term futility can, on the one hand, be defined strictly physiologically, in the sense of the clear impossibility of restoring the cardiac pumping function. The extended definition of the futility of resuscitation attempts, on the other hand, includes an estimate of the nature of survival (duration of survival, neurological outcome) after circulatory arrest. The two definitions share the problem of containing an evaluation of the objective of out-of-hospital resuscitation attempts. In emergency medicine the standard of care remains the start of resuscitation attempts. Physiologically defined futility justifies the decision to withhold resuscitative efforts. In a particular case the refusal by the patient as well as an expected bad prognosis which is inconsistent with the patient's interest could support the emergency physician's decision not to initiate resuscitation. Such an individual decision should not only be guided by medical, but also by ethical considerations and be based on general ethical principles.

Aged↗
PubMed1998

[Ethics in preclinical emergency medicine--on the topic of medical futility and resuscitation efforts].

In prehospital emergency medicine, physicians are repeatedly faced with the question of when cardiopulmonary resuscitation (CPR) efforts should be withheld or terminated since they are clearly futile. Here, futile means the goal of saving life cannot be achieved. Determining futility involves qualitative und quantitative aspects. Does the possibility of simply restoring circulatory function justify the decision to initiate resuscitation or must the prospect of a prolonged meaningful life exist? The question of futility arises for the entire life-saving team during resuscitation efforts, for example, after traumatic cardiopulmonary arrest, prolonged down time, collapses in chronically-sick nursing home residents or during transport to hospital when prehospital CPR failed to restore spontaneous circulation. Possible solutions to this problem lie in restricting the objective of resuscitation to achieving a physiological effect in an organ system, i.e. regaining the cardiac pumping function, and in taking into account the chance of long-term survival and quality of life of the patient. Basically speaking, general ethical principles must be adhered to and these include consideration of a patient's right to self-determination. In the prehospital setting, however, the emergency physician is usually confronted with an unknown and unconscious patient and has no information about his preferences. In general, the patient's will to live and his desire for every effort to be made to save him can be assumed, even when there is only a slight chance of survival. Thus, unilateral decisions by emergency physicians to withhold CPR are only justified in special cases when it is obvious that CPR and preservation of life would not be in the patient's interest. When in doubt, resuscitation attempts must be made. The futility of these efforts may emerge later in hospital, or information becomes available regarding the patient's will which justifies an end to therapy.

Cardiopulmonary Resuscitation↗
PubMed1998

[What is the future of palliative medicine in Germany?].

Traditional medical treatment approaches for incurably and terminally ill persons are often felt by the patients and their families to be lacking, since distressing physical and spiritual symptoms of the disease cannot be adequately addressed. In many cases, care in the final stage of life represents a complex medical challenge whose objective is to maintain an individually sufficient quality of life for the patient. New strategies for therapy and care evolving out of the international hospice movement have entered medical training programs under the heading of palliative medicine. Although palliative medicine has only recently enjoyed increasing acceptance in professional as well as lay circles in Germany, it is widespread in many Anglo-Saxon countries, where it also is offered as an academic discipline in research and teaching. According to the most recent American legal interpretations, palliative treatment has been approved as a constitutional right for patients with severely debilitating symptoms. Against the background of sweeping social restructuring, demographic and tumor-epidemiological developments are exerting increasing pressure on our modern societies to improve treatment approaches for incurable patients. In the public itself a changed and more open treatment of the topics of death and dying is becoming apparent, resulting in a demand as well for medical treatment options. From all this, as well as the fact that Germany has been strongly hesitant to establish palliative medicine facilities, it is apparent that there is a clear need to catch up in the area of palliative medicine treatment, research and teaching. The current mood of fiscal restraint in health care may delay medical progress, but it will not be able to prevent it.

Euthanasia↗
PubMed1998

[Pain therapy in tumor patients and in palliative medicine. 1: Drug therapy].

Like other industrial countries Germany experiences a significant increase of cancer prevalence. Recent advances in the treatment of various types of cancer resulted in prolonged survivaltimes of patients. Cancer--especially in advanced incurable stages--often is accompanied by severe pain. Therefore, the need for sufficient pain management and symptomcontrol is obvious. Throughout the last decades new drugs and techniques for the management of cancer-pain have been developed. Most cancer-patients should experience sufficient pain-management if existing recommendations for the pharmacological treatment of cancer-pain (e.g. WHO-guidelines) are followed consequently. In case of intractable pain or ongoing disabling symptoms despite proper therapy consultation of an expert in palliative medicine should always be considered as well as the option to refer the patient to a specialized pain-management center.

Analgesics↗
PubMed1998

[Pain therapy in tumor patients and in palliative medicine. 2: Invasive measures].

Anesthesiological and neurosurgical methods in the treatment of cancer pain have to be considered as parts of a holistic approach. To treat cancer pain patients appropriately, an interdisciplinary setting is essential. In the eyes of experienced pain specialists as well as physicians in palliative medicine invasive procedures are only of minor importance. Their use has been steadily decreasing while neuromodulatory (e.g. intraspinal opioids) or stimulatory (e.g. TENS, DBS, SCS) methods gained wider acceptance. The only neurolytic procedure which still has some importance is the neurolysis of the celiac ganglion for alleviation of pain in the upper abdomen mostly due to pancreatic cancer. This approach seems to be highly effective and tends to be afflicted with only minor complications. Other neurolytic blocks have shown solely local and temporal efficacy. In their majority they are unprecise and often accompanied by severe complications. Therefore these procedures should be scheduled only after carefully weighing risk versus benefit. Where suitable, the use of neurolytics is replaced by radiofrequency thermocoagulation, to a lesser degree by cryoanalgesia. Both procedures normally do not yield better analgesia but do result in fewer complications. Physicians tend to treat pain as a completely somatic disorder, but chronic pain states are always bio-psycho-social in nature. In order to achieve an effective pain treatment all influencing variables have to be taken into account. Anesthesiological and neurosurgical procedures are only a part of the possible and necessary treatment options. Especially before using one of the invasive methods described here, it seems imperative to involve the patient in the process of decision making more closely than currently practiced.

Analgesia, Epidural↗
PubMed1997

[Ethical conflicts in emergency medicine].

OBJECTIVE: Thirty years ago, cardiopulmonary resuscitation (CPR) was primarily developed for otherwise healthy individuals who experienced sudden cardiac arrest. Today, CPR is widely viewed as an emergency procedure that can be attempted on any person who undergoes a cessation of cardiorespiratory function. Therefore, the appropriateness of CPR has been questioned as a matter of the outcome, the patient's preferences, and the cost. The objective of this article is to analyse ethical issues in prehospital resuscitation. ARGUMENTS: CPR is bound by moral considerations that surround the use of any medical treatment. According to Beauchamp and Childress, the hierarchy of justification in biomedical ethics consists of ethical theories, principles, rules, and particular judgements and actions. The decision to start CPR is based on the medical judgement that a person is suffering from circulatory arrest. The decision is justified by the moral rule that the victim of a cardiac arrest has the right to survive and to receive CPR. Moral rules are more specific to contexts and are based on ethical principles. The principle of beneficence means the provision of benefits for the promotion of welfare. Talking about beneficence in resuscitation means once again reporting stories of success, as many victims of pre- and in-hospital sudden death have been saved in the past. Nevertheless, resuscitative efforts still remain unsuccessful in the majority of cases, involving the principle of nonmaleficence. There is potential harm in CPR. Survivors may recover cardiac function, but sustain severe hypoxic brain damage, at worst surviving without awakening for months or years. In particular, post-traumatic CPR is associated with an extremely poor outcome, leading to the issue of futility. However, futility should be defined in a strict fashion, as there might be an individual chance of survival. The principle of respect for autonomy means the right of a patient to accept or reject medical treatment, which continues in emergency conditions and after the patient has lost consciousness. The time frame in CPR requires medical decision-making within seconds, and CPR is usually initiated without the patient's involvement. If the patient's wish's can be ascertained later on, life-sustaining therapies might be withdrawn at the time. Terminally ill but still competent patients should be encouraged to write a no-CPR document, which does not deny patients relief from severe symptoms, but might facilitate withholding resuscitative efforts at the scene. The principle of justice affects priorities in the allocation of health care resources. The decision made for a particular patient might delay or prevent emergency treatment in other patients who could receive greater benefit. CONCLUSIONS: The standard of care remains the prompt initiation of CPR. However, ethical principles such as beneficence, nonmaleficence, autonomy, and justice have to be applied in the unique setting of emergency medicine. Physicians have to consider the therapeutic efficacy of CPR, the potential risks, and the patient's preferences.

Cardiopulmonary Resuscitation↗
PubMed1997

The decision to terminate resuscitative efforts: results of a questionnaire.

Despite all the progress made in emergency medicine, out-of-hospital resuscitative efforts still remain unsuccessful in the majority of cases and a decision concerning termination of cardiopulmonary resuscitation (CPR) has to be made. We used a multi-question survey to assess the attitude of emergency physicians towards the duration of an unsuccessful resuscitation attempt in non-traumatic cardiac arrest, and to identify the criteria affecting the decision to terminate CPR in the prehospital setting. More than 400 physicians participated in the inquiry on CPR in adults. If spontaneous circulation cannot be restored, the majority (65%) abandon the resuscitation attempt at the latest after performing advanced cardiac life support for 45 min. The participants indicated the following factors as criteria for the termination of unsuccessful CPR: pre-existing diseases (92%), presumed interval between onset of arrest and application of CPR (92%), duration of the resuscitation attempt (90%), age of the patient (89%), electrocardiographic (ECG) alterations such as persistent asystole/ventricular fibrillation or electromechanical dissociation (83%), persistent fixed and dilated pupils (78%), lack of brain stem reflexes (31%), body temperature (12%) and suspected drug intoxication (8%). The answers reflect the physicians opinions on termination of CPR even if they do not present real decisions under emergency conditions. The results indicate that in addition to the failure to restore spontaneous circulation, other factors are involved in decision making at the scene. A high rate of respondents include criteria of weak diagnostic value such as the pupillary status, or factors of doubtful prognostic significance such as the patient's age. Concerning the patient's history and underlying diseases, the emergency physician often has to resort to presumptions. We conclude that the decision to terminate CPR is made by most physicians considering the specific circumstances of the cardiac arrest.

Adult↗
PubMed1997

Skills of lay people in checking the carotid pulse.

American Heart Association as well as European Resuscitation Council require the carotid pulse check to determine pulselessness in an unconscious victim and to decide whether or not cardiopulmonary resuscitation (CPR) should be initiated. Recent studies on the ability of health professionals to check the carotid pulse have called this diagnostic tool in question and led to discussions. To contribute to this discussion we performed a study to evaluate skills of lay people in checking the carotid pulse. A group of 449 volunteers (most had participated in a first aid course) were asked to check the carotid pulse in a young healthy, non-obese person by counting aloud the detected pulse rate. Time intervals until correct detection of the carotid pulse were registered. Overall the volunteers needed an average of 9.46 s, ranging from 1 to 70 s. Only 47.4% of the volunteers were able to detect a pulse within 5 s, and 73.7% within 10 s. A level of 95% volunteers detecting the pulse correctly was reached only after 35 s. Based on these findings we conclude that the intervals established for carotid pulse check may be too short and that perhaps the value of pulse check within in the scope of CPR needs to be reconsidered.

Adult↗
PubMed1997

Prevention of patient bacterial contamination of anaesthesia-circle-systems: a clinical study of the contamination risk and performance of different heat and moisture exchangers with electret filter (HMEF).

The microbiological contamination of 250 breathing system tubes after use in anaesthesia circle systems with reduced fresh gas flow was investigated. The lungs of 50 patients were ventilated without any filtering device between the endotracheal tube and the Y-piece. A total of 51, 49 and 100 patients, respectively, were given different types of heat and moisture exchanger with electret filters (HMEF). With no filtering device the tubing system was contaminated by microorganisms originating from the patient's tracheal secretion in 13% of the patients. In contrast, no bacterial migration into the tubing system was detected when any of the investigated HMEF-devices were used. We therefore conclude that heat and moisture exchangers with electret filters prevent contamination of the anaesthesia breathing system with microorganisms from the patients airways.

Adult↗
PubMed1997

[Exitus letalis caused by liquid nitrogen].

A 24-year old student died from asphyxiation while filling flasks with liquid nitrogen. The upper and lower extremities and the back were frozen. The face, ears and neck were livid with a horizontal line of demarcation. A few wide ventricular complexes were seen in the initial ECG, followed by asystole. The patient's trachea was intubated, his lungs ventilated with 100% oxygen and CPR initiated. The site of larynx and pharynx were without pathological findings. 250 ml of a crystalloid solution were infused into the external jugular vein. It was not possible to measure the body temperature. Venous blood gas analysis showed a metabolic acidosis and hyperkaliaemia. CPR was terminated after 90 minutes. Own protection is most important for the rescue team if a nitrogen atmosphere is expected.

Adult↗