[Scanners].
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Tomography Scanners, X-Ray Computed↗
Biomedical subjects
D Khenfer
Publications and source records attributed to D Khenfer.
Pharmacokinetics of diltiazem in severe renal failure.
The acute effects of a single dose of diltiazem (Tildiem), a calcium antagonist, were studied in 9 patients with severely impaired renal function (GFR between 0.03 and 0.87 ml/s/1.73 m2). Control measurements were made of inulin and PAH clearance, creatinine, blood pressure, heart rate and ECG. Following administration of diltiazem 120 mg, 7 blood samples were collected in the first 12 h and after 24 h, 32 h, 48 h; urine was collected for the first 12 h, 12-24 h and 24-48 h, and blood pressure, heart rate and ECG were recorded after 6 h. Diltiazem and its main metabolite, desacetyldiltiazem, had a pharmacokinetic profile similar to that in patients with normal renal function (peak plasma concentration, half-life and urinary excretion). Diltiazem is normally eliminated in the urine to a small extent, because it is metabolized, and this also applies to desacetyldiltiazem, which is probably further metabolized.
Adult↗
Pharmacokinetics of caffeine during and after pregnancy.
The pharmacokinetic parameters of caffeine were measured in 9 pregnant women and 4 women 4 days post partum. The results show a significant prolongation of caffeine elimination in pregnant women. Normal pharmacokinetic parameters seem to be restored as soon as 4 days post partum. Steroids hormones (estriol, estradiol, and progesterone) were measured in both cases.
Adult↗
[Compared alteration in paracetamol and hexobarbital metabolism due to liver disease].
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Acetaminophen↗