Biomedical subjects
Publications and source records attributed to D Kob.
Based on a material of 90 patients with malignant ovarian tumours the results of a chirurgical-radiological combination therapy are discussed. The radiotherapy with telecobalt in the area of small pelvis and regional lymphatic drainage represented achieves good results with justifiable secondary effects. The 5-year survival rate is 36,1%.
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Based on a material of 136 patients with cervix cancer the results of radiation therapy partially combined with intracavitary radiotherapy are discussed. The 5-year survival rates are accordanted with good results of other authors. The 5-year survival rate is 17,6% in progressive cases with tumour invasion in the urinary bladder, from has to derived, that by application of megavolt therapy this group of patients is an indication for radiation therapy under curative terms.
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By autoradiographic examination by means of pulse labelling with 3H-thymidine cell cycle times were determined in solid Ehrlich carcinomas (early carcinomas) in order to obtain comparative values for irradiated tumours. The subcells of the initially labelled cells near the capillaries were found to distribute themselves in the course of 48 h over the whole tumour and to emigrate to hypoxic tumour areas.
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The effect of several fractionation regimes was examined by the model of mammary tumour in C3H-mice. The best results were observed with several fractionations daily. No curative effect was obtained by means of a total dose of 6000 rd achieved with all fractionation regimes. The results of investigations underline the importance of considering cellular proliferation kinetic processes in malignant tumours in order to optimize the temporal distribution of radiation dose.
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A report is given on the results of radiotherapy in 82 cases of labial carcinoma admitted to the Radiological Clinic, Jena. The absolute 5 years' healing for primary tumours is 73,25%. The absolute 5 year's healing for relapses is 68,9%. The absolute 5 years' healing for regional lymph node metastases is 21,8%.
Systematic investigations of the chorionic gonadotropin excretion were performed in 79 patients with testicular tumours. The influence of the hormonal activity in diagnosis and prognosis of metastatic testicular tumours was investigated. It was discovered, that the part of hormonal active testicular tumours is relatively small and that the evidence of the chorionic gonadotropin excretion is only possible in a few cases before the clinical and radiological evidence of metastases. The hormonal activity of testicular tumours is without influence on the survival time of tumour carriers.
The increasing use, in recent years, of surgical methods for the treatment of labial carcinomata caused us to review the results of treatment by means of irradiation. The different methods of radiotherapy are described, and a comparison is made between the results of radiotherapy and surgical treatment. Also, cases are described in which it is indicated to use either surgical treatment or radiotherapy or a combination of the two methods.
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