Biomedical subjects

D Koev

Publications and source records attributed to D Koev.

6 recordsLinked to original sources

PubMed1979

Plasma renin activity in diabetic patients.

Plasma renin activity (PRA) in 40 diabetic patients and 42 healthy controls was investigated using the method of Pickens in modification of Serebrovskaja et al. (1967). PRA was slightly lower in the whole group of diabetes but the difference was not significant. The subgroup of 20 maturity-onset diabetics had significantly lower PRA in comparison with 22 controls of similar age, while PRA in juvenile diabetics did not differ significantly from matched controls. In patients without clinical signs and symptoms of microangiopathy PRA was as high as in the controls. In diabetics with microangiopathy PRA was significantly lower. PRA was also lower in patients with longer duration of the disease. The stimulation of juxtaglomerular apparatus with sodium free diet and diuretic drugs resulted in an increase of PRA both in controls and diabetics. This suggests a functional depression of PRA in diabetic patients. In diabetics with ketoacidosis PRA was higher than in control subjects and decreased after disappearance of ketoacidosis. A high level was recorded in a patient with hyperosmolar coma and a very low level in a patient with polyneuropathy and severe orthostatic hypotension. The possible mechanisms involved in the changes of PRA in diabetic patients are discussed.

Adolescent↗

PubMed1978

[Treatment of diabetic ketoacidosis by continuous venous infusion of small insulin doses].

The authors treated 60 patients with diabetic ketoacidosis by continuous venous drop insulin infusion with 8 U every hour during the first six hours and after the sixth hour--20 U every three hours. Rehydration was performed with physiological serum in case of glycemia over 200 mg% and with 5% glucose serum in glycemia under 200 mg%. The patients were led out of ketoacidosis in approximately 9 hours and 36 minutes, the blood sugar diminution being slow and gradual, without hypoglycemic incidence. The average total insulin dose used was 72 U. The authors recommend that method for the practice with a view to its simplicity, safety and high effectiveness.

Adolescent↗

PubMed1977

[Acromegalic cardiopathy].

A patient with acromegaly is described with a relatively small eosinophilic adenoma of the hypophysis, the cardiopathy standing out on the foreground of the clinical pictrire, due to which it has for a long time been interpreted as a primary cardiac ailment. The cardiac disorder proceeds with cardiomegaly, conductivity disturbances and left, quickly progressing into complete and resistant to treatment cardiac insufficiency. The problem of the origination of the so called primary cardiac insufficiency is discussed, resulting from the direct effect of STH upon myocardium.

Acromegaly↗

PubMed1975

[Simmonds-Sheehan syndrome].

A woman of 30 with Simmonds--Sheehan syndrome is described that developed after delivery by vacuum-extraction of the fetus, due to powerless labour. The clinical picture was dominated by suprarenal cortical insufficiency, manifested with pains in the abdomen, vomiting, hypotonia and severe asthenic-adynamic syndrome. The substitutional hormonal treatment completely restored the general state and the working capacity of the patient.

Adult↗

PubMedDate not supplied

[State of the renin-angiotensin system in thyrotoxicosis].

A study was made of the blood plasma renin activity in 63 patients suffering from thyrotoxicosis before the treatment and in 42 healthy individuals. In comparison with the healthy, renin activity was increased in patients with thyrotoxicosis and displayed a positive correlation with the severity of the disease the level of protein-bound iodine, tachycardia and the degree of loss of weight. Stimulation of the renin-angiotensin system by the salt-free diet, hydrochlorthiazide and by placing the body into orthostatic position caused a relatively weaker increase in the renin activity in comparison with such in healthy individuals. Following successful treatment and the occurrence of an euthyroidal state renin activity proved to fall to the normal level. An increased renin activity was combined with increased urinary aldosterone excretion with a normal serum electrolyte level. Such combination pointed to the secondary character of aldosteronism. Block of the alpha- and beta-adrenergic receptors led to reduction in the level of renin activity. Despite the frequent affection of hepatic function there was revealed no correlation between the increase in the renin activity and the pathological results of hepatic tests. Plasma renin activity was reduced in 8 patients with myxedema. It is supposed that the principal factors causing activation of the renin-angiotensin system in thyrotoxicosis were the loss of water and electrolytes by the organism and the appearance of oversensitivity to adrenergic receptors.

Adrenergic alpha-Antagonists↗

PubMedDate not supplied

Plasma growth hormone level in the Morgagni-Stewart-Morel syndrome.

In 10 patients with Morgagni-Stewart-Morel syndrome the basal plasma growth hormone level was slightly increased. There was no decrease of plasma growth hormone after glucose loading in most of the patients. These findings were supported by the histological picture of the adenohypophysis of an accidentally died patient. A microadenomatosis of adenohypophysis consisting of acidophils or basophils was found. The increased growth hormone secretion might be responsible for the hyperostosis and some other features of the Morgagni-Stewart-Morel syndrome.

Acromegaly↗