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Biomedical subjects

D Kogut

Publications and source records attributed to D Kogut.

6 recordsLinked to original sources
PubMed1993

Omeprazole is superior to ranitidine plus metoclopramide in the short-term treatment of erosive oesophagitis.

Histamine H2-receptor antagonists are moderately effective in symptomatic treatment and healing of erosive oesophagitis, but they are not as effective as the proton pump inhibitor omeprazole. In some studies prokinetic agents seem to increase the effectiveness of H2-antagonists, but no study comparing the efficacy of omeprazole to H2-antagonists plus prokinetic agents has been performed. The purpose of this study was to compare the efficacy and tolerability of 20 mg omeprazole daily with 150 mg ranitidine b.d.s. plus the prokinetic agent 10 mg metoclopramide q.d.s. in patients with erosive oesophagitis. After both 4 and 8 weeks of treatment, omeprazole healed the mucosa in significantly more patients than did ranitidine plus metoclopramide. Omeprazole also provided significantly greater relief from daytime heartburn, nighttime heartburn, and acid regurgitation, and was associated with decreased concomitant antacid use. Although the overall incidence of adverse events was similar in the two treatment groups, a significantly higher number of treatment-related adverse events and more treatment-related withdrawals from the study occurred in the ranitidine plus metoclopramide treatment group. Omeprazole is more effective and better tolerated than the combination of standard dose ranitidine plus metoclopramide for patients with erosive oesophagitis.

Adult↗
PubMed1988

Validity of orally administered Beck and Zung Depression Scales in a state hospital setting.

Thirty-six consecutively admitted psychiatric inpatients were orally administered the Beck and Zung depression scales. Wide Range Achievement Test reading scores also were obtained. The Beck and Zung correlated significantly (p .001) with Diagnostic and statistical manual of mental disorders (DSM-III; American Psychiatric Association, 1980) depression criteria. When the patients were subdivided by diagnosis (Depression and mixed Depression vs. others), and depression scores compared, only the Zung significantly differentiated the two groups (F = 12.51, p less than .001). When subdivided by reading scores, both high (grade level M = 8.7) and low (grade level M = 3.2) groups' Beck and Zung scores correlated equally well with the DSM-III criteria measure. This study substantiates the common practice of orally presenting written tests to low functioning patients most convincingly in the case of the Zung Depression Scale.

Adult↗
PubMed1984

Therapists and quasi-therapists in a therapy analogue situation.

Evaluated an assumption from previous psychotherapy analogue studies, namely, that trained psychotherapists and untrained quasi-therapists with personality similarities will respond similarly to patient presentations. Ss were 24 male psychotherapists and 24 male undergraduate students, chosen partially on the basis of their responses to an A-B personality scale derived from the work of Whitehorn and Betz (1954). The three-factor experimental design included S personality type (A or B), S professional status (psychotherapist vs. student), and videotaped patient simulations (neurotic vs. schizoid), with all Ss exposed to both patient prototypes. Therapists demonstrated a higher degree of accurate empathy, were less active, made shorter responses, and used more declarative sentences (p less than .01 for each variable). Second-order interaction effects indicated that therapist personality type X patient type pairings produced opposite results for quasi-therapists when compared to professional therapists.

Empathy↗
PubMedDate not supplied

A multicenter, randomized, double-blind comparison of roxatidine with ranitidine in the treatment of patients with uncomplicated benign gastric ulcer disease. The Multicenter Roxatidine Cooperative Study Group.

Roxatidine (150 mg, 312 patients) was compared with ranitidine (300 mg, 308 patients) in a randomized, double-blind, parallel-group, 6-week therapeutic study for the treatment of patients with uncomplicated, benign gastric ulcer disease. The study end points (verified by using endoscopy results) were fully healed ulcers at 4 or 6 weeks. The results of roxatidine therapy were comparable to those of ranitidine therapy: healing rates of 52% and 54% at week 4 and 77% and 76% at week 6 were recorded for roxatidine and ranitidine, respectively. The drugs produced comparable reductions in ulcer diameters and decreases in abdominal pain. Adverse events associated with both roxatidine (27%) and ranitidine (28%) were headache, diarrhea, and dizziness; rash was associated in 6 of 8 cases and in only 1 case with roxatidine. In this trial, roxatidine 150 mg once daily was as efficacious and safe as ranitidine 300 mg once daily for treatment of patients with uncomplicated, benign gastric ulcer disease.

Adult↗