Biomedical subjects

D Konopinska

Publications and source records attributed to D Konopinska.

3 recordsLinked to original sources

PubMed1992

Interactions of selected insect neuropeptides with synthetic lipids.

Interactions of the insect neuropeptide proctolin (Arg-Tyr-Leu-Pro-Thr), its [beta-cyclohexyl-(4-O-methyl)2]-L-alanine analog, and the leucopyrokinin [2-8]-fragment (Thr-Ser-Phe-Thr-Pro-Arg-Leu-NH2), with synthetic phospholipids (DPPC, DMPE, DMPG) were studied using the microcalorimetric method. Most pronounced changes of the lipid thermotropic behavior were observed with DMPG/leucopyrokinin [2-8]-fragment mixtures. Proctolin itself was less active with all the lipids studied. The results obtained suggest that the studied peptides interact with the head group region of lipid bilayer.

Amino Acid Sequence↗

PubMed1986

Tuftsin.

Explore the source record for details and available documents.

Humans↗

PubMed1985

Modification of morphine withdrawal: effect of tuftsin, [Lys4]-tuftsinyltuftsin, tetrapeptide fragment (1-4) of substance P and its amide.

Withdrawal behavior in morphine-dependent rats precipitated by naloxone was attenuated after pretreatment with the tetrapeptide tuftsin and to some extent by its synthetic derivative [Lys4]-tuftsinyltuftsin. The tetrapeptide fragment (1-4) of Substance P was ineffective in suppressing morphine-withdrawal behavior, whereas its C-amide exerted only weak action. Possible involvement of an immunological mechanism is discussed.

Adjuvants, Immunologic↗