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D Kostić

Publications and source records attributed to D Kostić.

At least 55 records · Page 3Linked to original sources
PubMed1969

[Breast tumors].

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Adult↗
PubMedDate not supplied

[Dose-response effect of drugs in the chemotherapy of small-cell bronchial carcinoma].

Dose-intensity is an amount of drug delivered per unit of time, expressed as mg/m2/week, regardless of the schedule or route of administration. Relative dose intensity is an amount of drug delivered per unit of time relative to an arbitrary chosen standard single drug or, in a combination regimen, the decimal fraction of the ratio of the average dose-intensity of all drugs of the test regimen compared to the standard regimen. Calculations can be made with intended (planned) dose intensity or actual or received dose intensity. A positive effect of dose intensity on outcome (response rate) has been demonstrated in advanced ovarian, colon, breast cancers and lymphomas. Small-cell lung cancer (SCLC) is very responsive to chemotherapy, although in the majority of patients conventional-dose chemotherapy is not effective in meaningfully prolonging median survival. Randomized studies suggest that a dose may be important for the success of chemotherapy in SCLC. The aim of the present study was to investigate the relation between dose-intensity and tumour objective response in a group of patients with SCLC treated with two cysplatin-based regimens. Fifty patients were randomized to receive 60 mg/m2 of a cysplatin and 120 mg/m2 of etoposide on days 1, 3 and 5 (Group A), or the same dose of cysplatin and 120 mg/m2 of epirubicin (Group B). The intercylce interval was 4 weeks, and 6 cycles were planned. The planned dose-intensity of cysplatin was calculated as 15 mg/m2/wk. However, the actual or received dose-intensity of cysplatin was 12.55 +/- 1.7 mg/m2/wk and 13.62 +/- 3.1 mg/m2/wk in Group A and Group B of patients, respectively. In other words, in the combination with etoposide, 83.7% of the planned dose of cysplatin has been delivered, while in the combination with epirubicin the cysplatin dose-intensity was 90.8%. The received dose-intensity of etoposide was calculated as 77.7% (planned dose intensity was 90 mg/m2/wk and actual dose-intensity 70 mg/m2/wk). Similarly, the received dose intensity of epirubicin was found to be 82.3% (30 mg/m2/wk planned and 24.4 mg/m2/wk actual). The average dose intensity in Group A was found to be 80.72% and in Group B 86.04%. Compared to patients with stable and progressive disease, the patients obtained objective tumour response received 5% and 10% higher relative dose intensity of cysplatin in Group A and Group B, respectively. Relative dose intensity of etoposide and epirubicin were similar in patients with or without objective tumour response. In conclusion, a positive relation between cysplatin dose intensity and objective tumour response was demonstrated. A higher relative dose intensity of cysplatin could be reached in combination with epirubicin compared to combination with etoposide.

Aged↗
PubMedDate not supplied

[Intra-arterial administration of prostaglandin E1 in occlusive arterial diseases].

The authors present their result of a two-year follow-up of 106 patients to whom an intra-arterial perfusion of prostaglandin E1 was administered, as limb salvage procedure. The patients were in the IIIrd and IVth stage of occlusive diseases by Fountain, and surgical reconstructions were not possible. All patients were divided into five groups: A--diabetic angiopathy (5), B--distal form of atherosclerosis (40), C--diabetic angiopathy and atherosclerosis (45), D--Burger disease (10) and E--adjuvant therapy in reconstruction with poor run-off (6). The Doppler sonographic and angiographic measurements were performed. After transcutaneous (16 cases), or intraoperative (90 cases) introduction of the catheter into superficial of profunda femoral artery, a continuous intraarterial administration of prostaglandin E1 was carried out in a dose of 10 nanograms/kg body weight/minute (total dosage 3000 nanograms). The patients were controlled immediately after the treatment, as well as 1, 3, 6, 12, 24 and 36 months after the treatment. In efficiency of the treatment was estimated on the following basis: elimination of rest pain, healing of trophic ulceration and demarcation of gangrenous processes. Our late results of intra-arterial administration of prostaglandin E1 proved to be a very successful limb salvage procedure. The treatment was more successful in a connections between the upper knee arterial net and pedal arterial arches were preserved.

Adult↗
PubMedDate not supplied

[Indications for surgical treatment of acute superficial thrombophlebitis].

The acute superficial thrombophlebitis (AST) which may be considered as an "aseptic local inflammatory reaction to vein thrombosis" is a very common disease. The diagnosis of this illness is simple, and usually consists of anamnesis and physical examination. This is due to the fact that typical external signs of inflammation are always present. In such cases the conservative treatment was usually recommended and it included rest, elevation, alcoholic compresses, antipyretic and analgetic drugs. The operative treatment was carried out only if the process developed near the deep vein system, or if a suppurative inflammation was present. We believe that wider indications for operative treatment should be considered. We base this statement on the following facts: the operative finding always shows that the process is greater than we suppose after physical examination, and the operation is easier to perform before scar tissue has been formed at sites of inflammation. The following indications are considered for conservative treatment: AST of the upper limbs; AST of the lower limbs where the great saphaenous vein is not included; AST of the lower limbs including the great saphaenous vain on the level above the knee; Suppurative forms of AST. We plead for one act operation which shortens the time of hospitalisation and includes: Crosseectomia; Ligature, resection and extirpatin of the great saphaenous vein (Vasalve).

Acute Disease↗