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Biomedical subjects

D Kountouris

Publications and source records attributed to D Kountouris.

14 recordsLinked to original sources

[Effect of immunoglobulins on the course of therapy-resistant Klebsiella meningitis].

The case of a 28-year-old patient with refractory Klebsiella meningitis after surgical removal of an angioblastoma in the left cerebellar hemisphere (Lindau's tumour) as described in this article, shows the significance of immunoglobulin therapy in view of the synergistic efficacy increase of antibiotics and immunoglobulin. There were 4 meningitis relapses in a period of 8 months, each time 4 days after discontinuation of antibiotics, the therapy consisting of antibiotics only (penicillin G, gentamycin, lamoxactam, cefotaxim and chloramphenicol). These antibiotics, which were applied in accordance with the antibiogram, were discontinued each 16-32 days after the patient had become afebrile and CSF was free from bacteria. In spite of this, further meningitis relapses followed even when the CSF cell count dropped from 12000/3 to 32/3 cells. An attempt to apply gentamycin suboccipitally failed, since diplopia, nystagmus and headache occurred after a single application. The combination of chloramphenicol orally and immunoglobulin intravenously resulted for the first time in complete freedom from bacteria in the CSF. A single intrathecal application of 1 g immunoglobulin caused a temporary increase in CSF cells to 1200/3 and an anal temperature increase from 37% to 38% C. Urticaria exanthema was observed twice as a side effect of immunoglobulin therapy.

Anti-Bacterial Agents↗

[Cerebrovascular diseases in advanced and very old age. Significance and correlation of computer tomography studies of the skull and EEG].

118 patients between 50 and 90 years of age with an acute cerebrovascular disease were examined. While cranial computerized tomography was helpful in the differential diagnosis of ischemia or hemorrhage it was less helpful in the diagnosis of other cerebrovascular diseases (abnormalities, stenoses). Frequent EEG-analysis permitted in the cases of cerebral ischemia or hemorrhage prognostic conclusions as well as computerized tomography did. Atypical clinical syndromes could be better diagnosed by computerized tomography than by EEG.

Age Factors↗