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Biomedical subjects

D Kovacević

Publications and source records attributed to D Kovacević.

At least 19 recordsLinked to original sources
PubMed1999

Loss of heterozygosity of APC and DCC tumor suppressor genes in human sporadic colon cancer.

We examined 36 cases of human sporadic colon carcinoma and corresponding normal tissue samples to evaluate loss of heterozygosity at the APC and DCC tumor suppressor genes loci using restriction fragment length polymorphism polymerase chain reaction and variable nucleotide tandem repeat analysis. Observed informativity was 83% for APC and 75% for DCC. DNA from 6 (20%) of 30 informative tumors exhibited loss of heterozygosity at the APC locus. Loss of heterozygosity at the DCC locus was observed in 7 (26%) of 27 informative tumor DNAs. Our results support the view that malignant progression is a consequence of more than one genetic change and suggest that inactivation of APC and DCC genes plays a role in a multistep process of colon tumor progression.

Adenocarcinoma↗
PubMed1990

[Radiographic analysis of condyle position in patients with TMJ dysfunctions].

Decreased joint space is one of the basical radiographic signs of joint disease and correlation with crepitus the real clinical symptom of structural joint damage. The aim of this investigation is to find out if there is any correlation between the intrajoint condyle position and joint dysfunction symptomatology, by means of TMJ tomography evaluation. Among the patients with characteristic symptoms of TMJ dysfunction examined in our Departments, a group of hundred were tomographed (Polytom--Philips-Massiot). Thirty students not showing any anamnestic or clinical symptoms formed the control group. In the evaluation of radiographic findings we accepted the static relation between condyle and glenoid fossa in the maximal intercuspal position, where the joint space was divided in three almost equal parts. The radiographic findings of the relationship between condyle and glenoid fossa in the maximal intercuspal position are presented on with the intention of establishing the most characteristic differences between the groups. The statistical elaboration has been carried out by multivariante analysis of variance. The characteristic radiographic findings in our group of patient are: --excentric condyle position, --posterior condyle displacement and --marked asymmetry. Therefore, these findings represent efficient aid in TMJ dysfunction diagnosis, and show direction for repositioning of condyle in therapy dysfunction.

Adult↗
PubMed1989

[Clinical and immunologic aspects of chlamydial infections in infertile women].

UNLABELLED: Chlamydia Trachomatis (CT) infection of the genital tract ranges from clinically severe to the silent subclinical forms of pelvic inflammatory diseases which can result in fallopian tubes obstruction and subsequent infertility. Our investigations: The serum antichlamydial antibodies of 30 infertile patients and the cultures of Chlamydia Trachomatis from specimens of endometrial biopsies were determined as well as HSG and laparoscopic examinations. METHODOLOGY: The evaluation of serum antichlamydial antibodies were measured by ELISA test. The endometrial specimens for culture of Chlamydia Trachomatis were collected transcervically from the uterine cavity. The statistical analyses were calculated on the basis of Student t test. RESULTS: Immunological determinations showed the presence of antichlamydial antibodies in 43.6%. The endometrial cultures yielded growth of CT (36.6%) and histological signs of chlamydial endometritis were also discovered. This study pointed to the positive correlation between the results of endometrial biopsies (cultures), immunological (serological) investigations and clinical examinations showing that the chlamydial infection reached the Fallopian tubes from the endometrium which could result in infertility.

Chlamydia Infections↗
PubMed1980

Primary hypertrophic osteoarthropathy (PHO) and changes in the joints. Clinical, X-ray, scintigraphic, arteriographic and histologic examination of 19 patients.

Nineteen patients with PHO with onset in childhood are presented. In 7 cases the syndrome was found in other family members too. In clinical, X-ray scintigraphic, arteriographic, and plethysmographic investigations, joint affection was found in 14 patients. Clubbing of the fingers and toes was seen in all the patients and a periosteal reaction was found in the long bones in 11 patients. Arteriography was carried out in 5 patients and showed hypervascularization and arteriovenous anastomoses in the clubbed fingers. The gas analysis of the arterial blood did not show any pathological changes. The histological finding showed poorly vascularized and oedematous periarticular tissue and ossification in the periosteal area, while in the synovial membrane, slight, nonspecific inflammatory changes were seen.

Adult↗