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Biomedical subjects

D Krajícková

Publications and source records attributed to D Krajícková.

16 recordsLinked to original sources
PubMed2000

Mechanical thrombolysis of thrombosed hemodialysis native fistulas with use of the Arrow-Trerotola percutaneous thrombolytic device: our preliminary experience.

PURPOSE: To evaluate the feasibility of use of the Arrow-Trerotola percutaneous thrombolytic device (PTD) in the treatment of thrombosed hemodialysis native fistula occlusions. MATERIALS AND METHODS: Ten patients with native fistula occlusion underwent mechanical thrombolysis with use of the PTD. The standard PTD was used in seven patients and the over-the-wire device was used in three patients. Major outcomes of our study included procedure time, clinical success, complication rate, and 3- and 6-month patency rates. RESULTS: The technical success rate was 100% and the clinical success rate was 90% (9 of 10). In all 10 cases, the procedure was associated with angioplasty. There were no major complications. The mean time of successful procedures was 126.1 minutes. The 3- and 6-month primary patency rates were 70% and 60%, respectively; the assisted primary patency rate at 6 months was 80%. CONCLUSION: The PTD is an effective mechanical device for percutaneous treatment of thrombosed hemodialysis access. Our clinically successful initial experience with the PTD shows that the technique is rapid and safe for treatment of native fistula occlusions.

Feasibility Studies↗
PubMed2000

Evaluating the outcome of percutaneous transluminal angioplasty in renal graft artery stenosis using the areas under the time curve of glomerular filtration rate and blood pressure.

The benefit of percutaneous transluminal angioplasty (PTA) of transplant renal artery stenosis for ischemic nephropathy may be adversely affected by rejection or other complications. As a result, assessment of the effect of PTA on renal function or blood pressure is often difficult. In this paper, we evaluated the effect of PTA using the method of integrated glomerular filtration rate (GFR) based upon the area under the curve over a follow-up period (AUC0-1), to express the level of GFR in a simple manner despite its significant fluctuations. A similar procedure was used to evaluate mean arterial pressure (MAP). The method was employed to assess the outcome in 20 individuals before PTA, and 1, 3, 6, 9 and 12 months after PTA. In eight cases, rejection was detected while there was one case of glomerulonephritis in the graft during the follow-up period. Evaluation (AUCCcr)0-12 related to the integrated pre-PTA value of Ccr [(Ccr)0 x 12] revealed a rise in GFR by more than 20 % in 65 % of cases. No improvement was observed in seven individuals with post-PTA complications. When assessing the integrated value of MAP, success of PTA (a reduction by at least 10 %) was found in 85 % of cases. No significant correlation was found between the relative changes of integrated GFR and MAP. Our data suggest that evaluation of the integrated value of GFR or MAP on the basis of AUC0-t allows to characterize, in a simple manner, the level of graft function and MAP throughout the follow-up period in individual cases. Furthermore, it may provide additional information on the average values obtained at different time intervals after the therapeutic procedure.

Adult↗
PubMed1999

Intima-media thickness of carotid arteries in borderline hypertensives.

The purpose of this study was to assess the effect of the main risk factors for cardiovascular disease on the process of subclinical atherosclerosis in originally borderline hypertensives. The relation of far wall common carotid artery intima-media thickness (IMT CCA) measured by B-mode ultrasound to smoking, body mass index (BMI), blood pressure, lipids, and angiotensin-converting enzyme (ACE) gene polymorphism was analyzed. In 48 subjects examined (mean age, 61.9 +/- 2.54 years), median IMT CCA was 0.708 mm. Statistically significant differences in BMI (26.5 vs. 29.2 kg/m2, p < 0.025) and HDL-cholesterol level (1.42 vs. 1.1 mmol/l, p < 0.025) between the first and third tertile of IMT CCA were found. No differences were observed between "controls" and "cases" in blood pressure, total cholesterol, and triacylglycerols. No significant differences in IMT CCA were found between smokers and nonsmokers and among different alleles of the ACE gene. These data reflect the importance of HDL-cholesterol and BMI on the process of atherosclerosis within an otherwise homogeneous group of patients.

Adult↗
PubMed1999

Artificial emboli based on poly(2-hydroxyethyl methacrylate) particles in animal experiments.

Spherical poly(2-hydroxyethyl methacrylate) particles 0.4-0.6 mm in diameter prepared by suspension polymerization were used for embolization of the internal thoracic artery in ten dogs and the renal artery in two dogs. No signs of toxic or irritating effect of poly(HEMA), either on the artery wall, or surrounding tissues were found in any animal in intervals of observation lasting two weeks, three months or one year. Possible neocapillarity, the presence of fibrous bundles among the particles of poly(HEMA) and, eventually, their slow degradation, were symptomatic of reparative processes.

Angiography↗
PubMed1999

[Evaluation of the results of percutaneous transluminal angioplasty of arterial stenosis in the transplanted kidney using area under time curves of the glomerular filtration rate and blood pressure].

The benefit of percutaneous transluminal angioplasty (PTA) of renal transplant artery stenosis for renal hemodynamics is frequently adversely affected by rejection or another complication. As a result, evaluation of the effect of PTA is often difficult. Our study was designed to assess the effect of PTA using a method of integrated value of the glomerular filtration rate (GFR) calculated on the basis of the area under the curve over the follow-up period (AUC0-t). A similar procedure was employed to evaluate mean arterial pressure (MAP). The method was used to assess the outcome in 20 individuals before to PTA, and at 1, 3, 6, 9 and 12 months after angioplasty. A rejection episode was diagnosed in eight cases and glomerulonephritis of the graft in one. Using the evaluation of (AUCCcr)0-12 in relation to the integrated value before PTA (Ccr) x 12, a rise in GFR > 20% was found in 65% of cases. PTA failure was observed in seven individuals developing post-PTA complications. When assessing the integrated value of MAP, PTA was found to be successful (a reduction by at least 10%) in 85% of cases. No significant correlation was demonstrated between the integrated values of GFR and MAP. The results support the assumption that the evaluation of the integrated values of GFR or MAP using AUC0-t allows to characterize, in a simple manner, the degree of renal transplant function or MAP throughout the follow-up period, and to furnish additional information to the values obtained at individual time intervals after the therapeutic procedure.

Adult↗
PubMed1997

[Percutaneous transluminal angioplasty of the renal artery in transplanted kidneys].

UNLABELLED: The objective of the work was to evaluate the contribution of percutaneous transluminal angioplasty (PTA) to treatment of hypertension and the graft function of a transplanted kidney. Angioplasty of the graft artery was performed in 39 patients. Technical success rate: 85%. COMPLICATIONS: 13%--in particular during the first years after introduction of the method. Twenty seven patients were followed up on a long-term basis. Changes of the median arterial pressure (MAP) were evaluated as well as glomerular filtration (GF) assessed by creatinine clearance. Mean values: [table: see text] A statistically significant (p < 0.01) reduction of the median arterial pressure (drop by > 10 mm Hg) along with reduction of the number of antihypertensive drugs was recorded in 70% of the patients during the first year and in 80% kidney recipients in investigations extending beyond one year. A significant increase of glomerular filtration (by > 20%) was found in 40% of the patients, on average the rise was insignificant. During the follow up period 13 kidney recipients were transferred to a dialyzation programme due to failure of the grafts as a result of rejection. CONCLUSION: Percutaneous transluminal angioplasty of a stenosis of the graft artery is the method of first choice in the treatment of hypertension. It is of fundamental importance also in rare cases in order to preserve or improve graft function and thus delay dialyzation treatment.

Adult↗
PubMed1995

[Clinical picture and diagnosis of subarachnoid hemorrhage caused by a ruptured aneurysm].

Ruptured cerebral aneurysm is the most common cause of non-traumatic subarachnoid hemorrhage. Subsequent to this catastrophe, patients have usually evidence of severe headache with sudden onset, signs of meningeal irritation, and depression of consciousness. Difficulties in diagnosis arise when the clinical picture is not classical. Cerebral vasospasm following aneurysmal subarachnoid hemorrhage is the leading cause of death and disability after aneurysm rupture. In the presence of a typical history and a normal CT scan, lumbar puncture should be performed with spectrophotometry analysis of the supernatant. After subarachnoid hemorrhage has been confirmed, four-vessel angiography should be performed as soon as possible. The surgical treatment of subarachnoid hemorrhage caused by ruptured aneurysm is the method of choice.

Aneurysm, Ruptured↗
PubMed1993

The platelet functions in stroke.

The share of platelets in the process of atherosclerosis and its thrombotic complications depends on the rate of their activation, which can be assessed by investigating the plasmatic levels of platelet factor 4 (PF4). Authors made use of this method in 68 patients with ischemic stroke and searched for the correlation between the found results, clinical picture and supposed etiopathogenesis of the disease. On the grounds of given findings they reached the conclusion that the increased PF4 levels represent no sign of a cerebral complication but only characterize the group of risky patients threatened by their platelets function status.

Blood Platelets↗
PubMed1989

[Transitory global amnesia. Analysis of our group].

Syndrome of transitory global amnesia characterized by suddenly appearing and isolated disorder of the short-time memory is a manifestation of dysfunction of structures of the hippocampus-fornix system, dorso-medial nuclei of the thalamus and mediobasal areas of temporal lobes. Histories, clinical pictures and results obtained from auxiliary examinations were in detail analyzed in seven patients with the above diagnosis at the Department of Neurology in Hradec Králové and possible etiology of the disease was considered.

Adult↗
PubMed1989

[Contribution of spectrophotometry of the cerebrospinal fluid in the rational treatment of subarachnoid hemorrhage].

In connection with antifibrinolytic therapy of subarachnoid hemorrhage which reduces, especially at the acute stage, the risk of repeated bleeding, more frequent incidence of other serious complications was observed, i.e. late ischemic neurological deficiency. As this complication is prognostically serious and therapeutical effects are not satisfactory its prevention is necessary, which includes administration of antifibrinolytic drugs for a limited time period. Such period may be determined by means of dynamic study of hemoglobin degradation products in the liquor using liquor spectrophotometry.

Adult↗
PubMed1989

[Circulatory disorders in the vertebrobasilar drainage area].

The authors refer to the clinical symptoms and auxiliary investigation results in 50 out-patients monitored for vascular cerebral disease in attempt to make a reliable diagnosis of vertebrobasilar insufficiency. The computerized brain tomography (CT) and ultrasound vascular investigation though being highly reliable in routinely diagnosing ischaemia of carotid drainage, are of lesser informative value in respect with structures of posterior cranial fossa. The considerable risk of cerebral infarction onset in patients with vertebrobasilar insufficiency in history is mandatory for more efforts as to the etiopathogenetic management of such casualties.

Adult↗
PubMed1989

[Transient ischemic attacks in the carotid drainage area].

The 63-membered total of patients is referred to with clinical signs of transient ischaemic attacks (TIAs) in carotid supplied area in account to the risky factors, results of selective auxiliary testing methods as well as the disease prognosis providing harmful occurrence of cerebral palsy completed.

Aged↗