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D Kranz

Publications and source records attributed to D Kranz.

113 records · Page 7Linked to original sources
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[Simulation of the effect of biologically active substances in models].

The results obtained from historadioautographic examinations of the epithelium of the small intestine of rats under the action of procaine served as a basis for examining the proliferative system by using a model. The following results have been obtained through computerized simulation: 1. The maximum life-time of the enterocytes is prolonged at constant villous height, which means that on average the villous is studded with older cells than normally. 2. The prolonged time of generation of the proliferatively active cryptic epithelial cells calls for a pronounced reduction in the pool of reserve cells (cells in the G0 phase, non-growth fraction), i.e. for their activation in order to realize the system characteristics described under 1. 3. The condition of the system induced by procaine may be compared, in its changed tendency, neither to the changing tendencies during aging nor to those under pathological conditions. It is rather a new condition that is being produced and which is characterized, inter alia, by the characteristics described under 1 and 2.

Aging↗
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The influence of biologically active substances on the regenerative processes of enterocytes in the small intestine of the rat.

The influence of a prolonged treatment with procaine or Turigeran on the cell population kinetics of the mucous membrane of the small intestine was studied by means of 3H-thymidine histoautoradiography in 240 12-month-old male Wistar rats. The investigations produced the following findings: 1. There are no differences in the cell population kinetics of the mucous membrane of the small intestine between procaine- and Turigeran-treated animals. But as, on the other hand, significant differences are found between treated and untreated animals in terms of all cell-kinetic characteristics, this effect has to be attributed to procaine alone. 2. In treated animals the partial stages of the cell cycle are prolonged as a result of which the generation time is delayed. 3. Due to the fact that the transit time of the cells in the crypts and on the villi is reduced, a greater number of labelled cells can finally be observed despite reduced proliferation rates in the crypts (labelling index) of treated animals. 4. Procaine will continue to act with undiminished effectiveness for at least two weeks after discontinuation of treatment.

Animals↗