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Biomedical subjects

D Kumar

Publications and source records attributed to D Kumar.

At least 325 records · Page 18Linked to original sources
PubMed1987

Fractionation and characterisation of the cysticercus of Taenia solium.

Fractionation by chromatography on Sephadex G-200 of a saline extract of Cysticercus cellulosae scolex antigen yielded three distinct fractions associated with distinct peaks. These fractions were analysed by double immunodiffusion (DID) and immunoelectrophoresis (IEP). The three peaks gave five, four and three antigenic determinants, respectively, by DID with homologous hyperimmune rabbit serum. However, the same serum gave nine antigenic determinants of scolex antigen by DID and 11 components by IEP. The IEP demonstrated seven and five antigenic components in the first two peaks. The first peak gave a stronger reaction in indirect haemagglutination than the others. There were common antigenic components in C cellulosae and C tenuicollis antigens.

Animals↗
PubMed1987

Cell-mediated immunological status and association of genetic markers in hereditary cerebellar ataxia.

Sixteen unrelated patients with hereditary cerebellar ataxia (HCA) were studied for genetic association with HLA and sixteen other genetic markers. Cell mediated immunological status of these patients was also studied by in vitro lymphocyte transformation tests. HLA typing was done in five three-generation families of patients with autosomal dominant cerebellar ataxia (ADCA). Linkage between HLA and ADCA loci was analysed using LIPED. Negative lod scores were observed in all five families. This lack of evidence for linkage between the HLA and ADCA loci is attributed to genetic heterogeneity of the disease in the families studied. No significant deviation was found in lymphocyte function to mitogen/antigen stimulation. A possible association of B12 (B44) antigen with ADCA is suggested.

Cerebellar Ataxia↗
PubMed1986

Hereditary cerebellar ataxia and genetic linkage with HLA.

Five families with at least three generations of members affected with autosomal dominant spinocerebellar ataxia (SCA) were studied. HLA typing was carried out and the coded HLA haplotypes were used to calculate the likelihood of linkage using the LIPED computer program. The combined lod scores from these five families does not, by itself, support linkage. Negative lod scores were observed in all five families, however, when pooled with the previously published data significant lod scores were obtained [Z = 3.343 (theta = 0.20) and +4.286 (theta = 0.30)]. In four families, affected members had clinical features consistent with autosomal dominant cerebellar ataxia (ADCA) type I while in the fifth, ADCA type II was suggested. Clinical heterogeneity within ADCA raises doubts about the significance of summed lod scores. In view of the previous reports probably two genetically heterogeneous types of ADCA exist -- HLA linked and nonlinked.

Adolescent↗
PubMed1986

Effects of different types of stress and of "prokinetic" drugs on the control of the fasting motor complex in humans.

Upper small bowel motility was continuously recorded for 36-48 h in 37 healthy ambulant volunteers using twin pressure-sensitive radiotelemetric capsules tethered in the small bowel. Each study began with a 24-h period that was free of applied stress. The second 24-h period included 7 h of intermittent psychological stress during the day and brief episodes of acute stress during the following night, except in the members of a control group to whom no stress was applied. Stress responses were assessed from cardiovascular status and self-reported visual analogue scales. Applied stress during the second day significantly inhibited the incidence of fasting migrating motor complexes compared with the first day; when no stress was applied there was no reduction in migrating motor complexes. Nocturnal stress was less effective in the inhibition of migrating motor complexes. All the stressors induced positive cardiovascular and subjective stress responses. The stress-induced inhibition of migrating motor complexes was reversed by oral metoclopramide; however, the drug did not reverse the cardiovascular or subjective response to stress. In contrast, domperidone did not inhibit the gastrointestinal effects of stress. Neither drug appeared to influence small bowel motility under normal conditions.

Adult↗
PubMed1986

Circadian variation in the propagation velocity of the migrating motor complex.

Using twin intraluminal pressure-sensitive radiotelemetric capsules for prolonged monitoring of proximal small bowel motility in healthy volunteers, we observed a significant (p less than 0.001) variation between daytime (6.44 +/- 0.74 cm/min, mean +/- SD) and nocturnal (2.90 +/- 0.35 cm/min) propagation velocities of the migrating motor complex. An identical variation in propagation velocity was observed in patients suffering from the irritable bowel syndrome. These data suggested a circadian variation, but did not exclude alternative hypotheses. Data were therefore compiled from healthy sheep and pigs supplied with ad libitum rations each morning and adapted to a 12 h light, 12 h dark schedule. Recording from implanted electrodes showed a significant (p less than 0.01) reduction in migrating motor complex velocity from 27.8 +/- 5.1 cm/min by day to 16.7 +/- 3.1 cm/min at night in sheep, and from 20.6 +/- 2.4 to 13.4 +/- 1.9 cm/min in pigs. The nocturnal reduction remained when the animals were fed in the evening. These observations suggest a circadian variation in mammalian migrating motor complex propagation velocity that is not merely a function of variation in intraluminal content.

Animals↗
PubMed1986

Comparison of effects of fentanyl and alfentanil on intra-ocular pressure. A double-blind controlled trial.

The effects of fentanyl and alfentanil on intra-ocular pressure during anaesthesia were investigated in 50 consecutive patients in a double-blind controlled trial. Both drugs produced a significant reduction in intraocular pressure (p less than 0.01). Alfentanil produced significantly greater reduction (48.5 percent) than fentanyl (28.6 percent) (p less than 0.01). A small but statistically significant reduction in arterial pressure (15 percent approximately) and heart rate (18 percent approximately), were observed with both agents, but no significant differences between them were noted. It is suggested that alfentanil may be a suitable alternative to fentanyl in ophthalmic anaesthesia.

Adjuvants, Anesthesia↗
PubMed1986

A family with craniofrontonasal dysplasia, and fragile site 12q13 segregating independently.

Coronal craniosynostosis, hypertelorism, telecanthus, broad grooved nasal tip, dental anomalies, mild syndactyly and broad thumbs, consistent with craniofrontonasal dysplasia are described in a family of four affected females over three generations. Documentation of the family is of interest because of variable clinical features and an excess of affected females. The excess of females observed in this condition is as yet unexplained, but cannot be referred simply to X-linked dominance with lethality in the male. Autosomal dominance with less frequent and less severe expression in the male is more tenable. Chromosome analysis on two affected family members revealed a fragile site at 12q13, which was also found in a phenotypically normal family member. A third affected individual did not exhibit this fragile site. Thus it appears that there is a heritable fragile 12q13 site segregating in this family separately from the gene for craniofrontonasal dysplasia.

Abnormalities, Multiple↗
PubMed1986

Autosomal dominant onychodystrophy and anonychia with type B brachydactyly and ectrodactyly.

A family is reported with nail dysplasia and/or absent nails, long and broad finger-like thumbs, camptodactyly and absent fingers. Radiological studies revealed hypoplasia of metacarpals, metatarsals and distal phalanges. Two affected individuals have absent metacarpals and phalanges. The clinical and radiological features may constitute a distinct syndrome of autosomal dominant onychodystrophy and anonychia with Julia Bell brachydactyly type B.

Adult↗
PubMed1986

Studies on the efficacy of diethyxime as an antidote against organophosphorus intoxication in rats.

Diethyxime, a non-quaternary cholinesterase reactivator was evaluated for its antidotal efficacy against organophosphorus intoxication in rats using the protection index, cholinesterase reactivation and neuromuscular function as the experimental protocol. Diethyxime along with atropine produced a marked antidotal effect against dimethyl dichlorovinyl phosphate (DDVP) poisoning on all the parameters studied. The action of diethyxime was mainly peripheral. The protective efficacy against diisopropyl fluorophosphate (DFP) poisoning was not observed with this reactivator.

Animals↗
PubMed1986

Morbidity in preschool Giardia cyst excretors.

Preschool children of two villages of Kharar Taluka, Ropar district, Punjab (India) were screened for the prevalence of giardiasis. Cysts of Giardia lamblia were found in 35.1% of the stool samples and other parasites were rarely seen. The incidence of diarrhoea in association with G. lamblia positivity was 16.5% in subjects whose stool examination was positive on one or more than one occasion. No difference in the incidence of giardiasis could be seen in well nourished and undernourished children living in these endemic areas.

Body Weight↗
PubMed1985

The irritable bowel syndrome: a paroxysmal motor disorder.

Upper small bowel motility was recorded for more than 30 h in each of 22 patients with the irritable bowel syndrome (IBS) and in two control groups, one consisting of 10 healthy volunteers and the other of 5 patients with inflammatory bowel disease. When subjects underwent a long period of intermittent mental stress, one or more of three motor abnormalities occurred in 19 patients; and only one abnormality was seen in 1 control (p less than 0.0001). These abnormalities were the total abolition of migrating motor complexes under stress, and abnormal irregular contractile activity, which was either spontaneous or evoked by stress. Sometimes the irregular contractile activity coincided with the occurrence of typical IBS symptoms. Males predominated (p = 0.05) among those with spontaneous irregular motor activity, who tended to have more symptoms (p = 0.014) than did those affected only by stress. The data suggest that irritable bowel syndrome is a paroxysmal motor disorder which may be detected in the small bowel and which may be either spontaneous or evoked.

Adult↗
PubMed1985

Macrodactyly of the hand and foot.

Five patients with macrodactyly are described. The foot was affected in 3 of them and the hand in 2. Two patients were operated on and the histological features are described. The literature is fully reviewed and the aetiology is discussed.

Adolescent↗