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Biomedical subjects

D Kushner

Publications and source records attributed to D Kushner.

17 recordsLinked to original sources
PubMed1996

Hand-foot-and-mouth disease.

Hand-foot-and-mouth disease is a highly contagious disease most often seen in children during the summer. It is caused most commonly by the virus coxsackie A16, but other enteroviruses have been implicated. It presents with low grade fever, and a vesicular eruption on the hands, feet, and mouth. More serious manifestations are seen less commonly. Diagnosis is most often clinical and treatment is symptomatic in nature. The infection in a male adult is presented.

Child, Preschool↗
PubMed1996

Kaposi's sarcoma versus bacillary angiomatosis.

Persons with acquired immune deficiency syndrome (AIDS) are subject to a host of pathologic entities secondary to a depressed immune system. Kaposi's sarcoma frequently presents in this immunocompromised population and, therefore, diagnosis seems clinically straightforward. However, because of the prevalence of a strikingly similar infectious disease known as bacillary angiomatosis, skin biopsy of one or more lesions is crucial.

AIDS-Related Opportunistic Infections↗
PubMed1995

Total hip replacement and other orthopedic hip procedures.

The history of total hip replacement including that of the Girdlestone procedure and resurfacing procedures is discussed. An overview of total hip replacement and its indications and complications forms the bulk of this section. Also, the use of porous-coated prostheses and endoprostheses as well as pins and plates is discussed and illustrated.

Bone Cements↗
PubMed1992

A successful technique for the treatment of diabetic neurotrophic ulcers.

Over 90% of the diabetic neurotrophic ulcers treated with the felted foam technique at the Cleveland Foot Clinic have completely healed. The average healing time for plantar ulcers has been approximately 8 weeks. After the ulcerations have healed, molded shoes or orthopedic shoes with Plastazote inserts are prescribed. The felted foam technique is simple to perform in an office setting and can be used by both the novice and the experienced practitioner.

Adhesives↗
PubMed1992

Voices From the Future: what students, interns, and residents want from osteopathic graduate medical training.

The need to attract students to--and keep them in--osteopathic internship and residency programs is great. Recognizing this fact, the osteopathic hospitals, through the American Osteopathic Hospital Association, have placed a renewed focus on liaisons with osteopathic medical education. Voices From the Future represents one such effort. This report reveals how osteopathic medical students, interns, and residents perceive the current state of osteopathic graduate medical education programs as well as the changes that they would like to see incorporated.

Education, Medical, Graduate↗
PubMed1992

Primary podiatric care of the vascularly compromised patient.

Primary podiatric care encompasses patient education, disease prevention, diagnosis, treatment, and patient referral. When performed on a regular basis, primary podiatric care can delay or prevent some of the complications associated with the vascularly compromised patient.

Foot Diseases↗
PubMed1991

Polyamines in the anemia of end-stage renal disease.

The improvement in the anemia in patients with end-stage renal disease (ESRD) on continuous ambulatory peritoneal dialysis (CAPD) suggests that dialyzable substances present in the sera of uremic patients either inhibit erythropoiesis directly or inactivate erythropoietin (EPO). In the present study predialysis sera from patients with ESRD inhibited erythroid colony (CFU-E) (N = 10) formation to a significantly (P less than 0.01) greater degree than granulocyte-macrophage (CFU-GM) (N = 7) colony formation in mouse bone marrow (MBM) cultures. The polyamines spermine (SP) (18 to 560 nm/ml) and spermidine (SD) (4 to 648 nm/ml) exerted a more significant (P less than 0.05) inhibition of CFU-E (N greater than or equal to 5) than that of CFU-GM (N greater than or equal to 5) growth. Concentrations of 0.80, 1.0, and 1.5 nm/ml of putrescine (PU) were 92%, 85%, and 77% of erythroid colony (CFU-E) controls (N = 4) and 104%, 130%, and 127% of CFU-GM controls (N = 4). Putrescine (PU) at 1.5 nm/ml also produced a significant (P less than 0.05) inhibition of CFU-E, whereas CFU-GM were stimulated by PU. These data suggest that predialysis sera from uremic patients, as well as SP, SD, and PU, are selectively more inhibitory to CFU-E than CFU-GM growth. The immunoreactivity of EPO was not significantly changed when it was coincubated with SP, SD and PU and measured by radioimmunoassay. PU was found to inhibit noncompetitively the bioactivity of EPO in a CFU-E assay. These data support the hypothesis that polyamines may be important uremic toxins in the anemia of ESRD.

Anemia↗
PubMed1988

Epiphyseal replacement using developing tissue donors in a murine model: a combined histologic and radiographic study.

Epiphyseal transplantation has long been a goal of orthopaedic surgeons. While microvascular surgery has raised hopes that this goal could be achieved, factors other than blood supply also appear capable of affecting the function of the epiphysis. Basic research into the biology of the epiphysis appears to be required. This would be facilitated with a model of epiphyseal transplantation using a small mammal. The purpose of this experiment was to develop such a model in the mouse. Developing CD1 mouse or Lewis rat limb tissue was used to replace knee tissue that had been resected from CD1 postnatal mouse hosts. Donor tissue ranged from 14-day embryonic mouse to 9-day postnatal mouse or 18- and 19-day fetal rat, which has a gestation similar to the mouse. The murine tissue is known to be avascular prior to the sixth postnatal day. The limbs were analyzed radiographically and histologically. The results show that epiphyseal replacement could be studied using developing tissue donors in a murine model. The results suggest that donor tissue prior to vascularization and tissue combinations with the least developmental time mismatch (the least heterochronicity) produced relatively the best, although still abnormal epiphyses.

Animals↗
PubMed1983

Transaxial tomography: an alternative to computerized tomography in pediatric orthopedic problems.

Because of the information it provides, computerized tomography has gained wide acceptance. However, the radiation delivered is considerable, and the gonads cannot be shielded effectively. Transaxial tomography also produces a cross-sectional image. While the image has less resolution, it is obtained at a fraction of the exposure. The use of transaxial tomography in several clinical situations is outlined here.

Bone Diseases↗
PubMed1982

Hospital expansion of ambulatory-care services: implications for pharmacy.

Implications for hospital and community pharmacists of the hospital industry's increased involvement in ambulatory care are discussed. There will certainly be competition between hospital and community pharmacists for the right to provide pharmaceutical services to ambulatory patients. Various developments are encouraging hospitals to expand their ambulatory services, and these will increase the competition and add urgency to minimizing confrontation between the two groups. The need for a forum within pharmacy to discuss difficult issues such as this is emphasized.

Ambulatory Care↗
PubMed1980

A comparison of speech intelligibility between esophageal and normal speakers via three modes of presentation.

This study compared intelligibility scores obtained for sentences read by good-to-superior esophageal speakers with scores obtained for sentences read by normal speakers via three modes of presentation: visual, auditory and auditory-visual combined. Statistical analysis showed significant differences between intelligibility scores for esophageal speakers and for normal speakers in the auditory and in the combined conditions. No significant difference was found between the scores for the two groups in the visual condition. Further analysis showed that the esophageal speakers' intelligibility scores improved significantly from the auditory to the combined auditory-visual condition where they most closely approximated, but never equaled, the highest intelligibility scores for normal speakers. Implications of the findings for rehabilitation of esophageal speakers are discussed.

Audiovisual Aids↗
PubMed1978

Letter recognition ability of aphasic subjects.

This study examined the letter-recognition abilities of 44 aphasic and 10 normal subjects. On a 26-item letter recognition task normal subjects made no errors. Moderately aphasic subjects illustrated minimal difficulty but did not differ significantly in performance from normals. Severely aphasic subjects exhibited marked impairment and made significantly lower letter-recognition scores than moderate aphasic or normal subjects. Type of aphasia as determined by conversational speech fluency (fluent or nonfluent) seemed to affect the letter-recognition performance of the severely aphasic subjects. Fluent severely aphasic subjects made significantly lower scores than all groups; nonfluent severely aphasic subjects made significantly lower scores than all groups except the severe nonfluent group. The types of letter-recognition errors produced by the two severely aphasic groups offer some explanation as to their performance differences. Errors of the latter group were more likely to be related to the stimulus letter; errors from the former group tended to be random. Findings indicate the intactness of the aphasic subjects's semantic associational network is important to the letter-recognition process.

Adult↗
PubMedDate not supplied

Mild traumatic brain injury: toward understanding manifestations and treatment.

Mild traumatic brain injury is misleading as a diagnostic term, as it may include a spectrum of manifestations ranging from transient mild symptoms to ongoing disabling problems. It is a source of significant economic burden to society in terms of days lost from work and costs related to medical treatment. Symptomatic individuals will frequently present to primary care general medical practitioners days, weeks, or even months after the trauma. General medical practitioners are thus put in the position of being the "gatekeepers" of medical care for such patients and become responsible for appropriate determination and authorization of medical tests, specialized referrals, and treatment. The purpose of this article, which is based on a review of the literature to 1997, is to provide physicians with an understanding of mild traumatic brain injury, including manifestations and treatment, as it occurs commonly and can significantly impact the quality of life of those affected.

Brain Concussion↗
PubMedDate not supplied

Solitary osteochondroma of the foot: an in-depth study with case reports.

Osteochondroma represents the most common benign bone tumor and occurs most frequently in the proximal humerus, tibia, and distal femur. The bones of the foot, by comparison, are less commonly involved. The tumor appears to be a developmental defect of bone preformed in cartilage rather than a true neoplasm. However, on rare occasions it may undergo chondrosarcomatous degeneration, thus demonstrating neoplastic behavior. A review of the literature, including clinical features of osteochondroma, radiologic and histologic characteristics, and theories on pathogenesis, is presented. Information concerning principles of surgical treatment, techniques of diagnosis, and facts to aid in the differential diagnosis of osteochondroma is presented also. Finally, a series of case reports is presented to demonstrate the surgical treatment of osteochondroma of the foot. Included are three cases of phalangeal osteochondroma, one of metatarsal osteochondroma, and an unusual report of osteochondroma of the talus. A case report and discussion of a patient with juxtacortical circumscripta myositis ossificans of the foot is also presented to demonstrate how information on lesions included in the differential of osteochondroma can be utilized clinically to make the diagnosis.

Adult↗