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Biomedical subjects

D L Carter

Publications and source records attributed to D L Carter.

24 records · Page 2Linked to original sources
PubMed1985

The use of urethane sponge matrix to assess in vivo recovery of murine cellular immunity following syngeneic bone marrow transplantation.

A unique method for assessing the in vivo recovery of cellular immunity following sublethal irradiation and syngeneic bone marrow transplantation of CBA/J mice is described. This method employs the serial surgical implantation of a urethane sponge matrix followed by impregnation of the sponge matrix with alloantigen. Sponge matrices were harvested from each mouse subject at 2 weeks, 4 weeks, and 8 weeks post transplant with and without treatment with interleukin-2. Recovery of cellular immunity was assessed as a function of cytotoxic T lymphocyte activity via cell-mediated lympholysis using chromium labeled targets. Repetitive procedures of implantation and removal of the matrices from the same animal were surgically feasible and were exceptionally well tolerated by the animals with insignificant morbidity thereby permitting continuous monitoring of immunologic recovery. Although the results of treatment with interleukin-2 were inconclusive, this method provides a sensitive, technically manageable means by which to assess an antigenic response in vivo at predetermined time intervals utilizing the same mouse subject. The method additionally affords the potential of being applicable to the in vivo assessment and manipulation of other aspects of the immune response.

Animals↗
PubMed1980

Preferences for wavelength and intensity in rhesus monkeys: fact or artifact?

10 adult male rhesus monkeys were tested to determine whether systematic preferences existed for specific color or brightness of visual stimuli. In contrast with previous reports no significant preferences for either specific hues or brightness levels were found. Perhaps methodological or subject variables may be responsible for preferential responding in other situations and account for the present inability to confirm prior work on preferences for color and brightness.

Animals↗